Title:
STREAMLINED SYNTHESES OF FLUOROQUINOLONES
Document Type and Number:
WIPO Patent Application WO/2018/231747
Kind Code:
A3
Abstract:
Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.
Inventors:
GUPTON FRANK B (US)
TOSSO PERRER N (US)
TOSSO PERRER N (US)
Application Number:
PCT/US2018/036991
Publication Date:
January 24, 2019
Filing Date:
June 12, 2018
Export Citation:
Assignee:
UNIV VIRGINIA COMMONWEALTH (US)
International Classes:
C07C227/16; C07C229/34; C07D215/56
Foreign References:
| US5639886A | 1997-06-17 | |||
| US5051418A | 1991-09-24 |
Other References:
BENNEVILLE ET AL.: "Reaction of beta-Alkoxyacrylic Esters with Secondary Amines", J. AM. CHEM. SOC., vol. 72, no. 8, 1950, pages 3725 - 3726, XP055563358, Retrieved from the Internet
SCHWALBE ET AL.: "Synthesis of a Library of Ciprofloxacin Analogues By Means of Sequential Organic Synthesis in Microreactors", QSAR & COMBINATORIAL SCIENCE, vol. 24, no. Issue 6, 16 August 2005 (2005-08-16), pages 758 - 768, XP055101234, Retrieved from the Internet
AMII ET AL.: "Flow microreactor synthesis in organo-fluorine chemistry", BEILSTEIN J. ORG. CHEM., vol. 9, 5 December 2013 (2013-12-05), pages 2793 - 2802, XP055563363, Retrieved from the Internet
See also references of EP 3638648A4
SCHWALBE ET AL.: "Synthesis of a Library of Ciprofloxacin Analogues By Means of Sequential Organic Synthesis in Microreactors", QSAR & COMBINATORIAL SCIENCE, vol. 24, no. Issue 6, 16 August 2005 (2005-08-16), pages 758 - 768, XP055101234, Retrieved from the Internet
AMII ET AL.: "Flow microreactor synthesis in organo-fluorine chemistry", BEILSTEIN J. ORG. CHEM., vol. 9, 5 December 2013 (2013-12-05), pages 2793 - 2802, XP055563363, Retrieved from the Internet
See also references of EP 3638648A4
Attorney, Agent or Firm:
WHITHAM, Michael E. et al. (US)
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