Title:
STREPTAVIDIN-BONDED MAGNETIC PARTICLES AND MANUFACTURING METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2012/111685
Kind Code:
A1
Abstract:
Provided are streptavidin-bonded magnetic particles having a high biotin binding capability, and a manufacturing method for the same. Streptavidin-bonded magnetic particles characterised by having a structure in which streptavidins are cross-linked on magnetic particles. A manufacturing method for streptavidin-bonded magnetic particles including the following steps. (1) A step for preparing a suspension containing magnetic particles having amino groups on the surface thereof; and (2) a step for adding glutaraldehyde to the suspension prepared in step (1), in the presence of streptavidin, and reacting the magnetic particles with the streptavidin and glutaraldehyde. These streptavidin-bonded magnetic particles, and streptavidin-bonded magnetic particles manufactured by means of this manufacturing method can be used in clinical diagnosis.
Inventors:
ARAI, Nobuyuki (())
荒井 信之 (())
MATSUOKA, Yasuhiro (())
荒井 信之 (())
MATSUOKA, Yasuhiro (())
Application Number:
JP2012/053463
Publication Date:
August 23, 2012
Filing Date:
February 15, 2012
Export Citation:
Assignee:
KYOWA MEDEX CO., LTD. (8-10, Harumi 1-chome Chuo-k, Tokyo 04, 〒1046004, JP)
協和メデックス株式会社 (〒04 東京都中央区晴海一丁目８番１０号 Tokyo, 〒1046004, JP)
ARAI, Nobuyuki (())
荒井 信之 (())
協和メデックス株式会社 (〒04 東京都中央区晴海一丁目８番１０号 Tokyo, 〒1046004, JP)
ARAI, Nobuyuki (())
荒井 信之 (())
International Classes:
G01N33/53; G01N33/543; G01N33/553
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Claims:
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