STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA

Title:

STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA

Document Type and Number:

WIPO Patent Application WO/2012/145630

Kind Code:

A3

Abstract:

The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.

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Inventors:

FISCHETTI VINCENT A (US)
SCHMITZ JONATHAN (US)
GILMER DANIEL (US)
EULER CHAD (US)

Application Number:

PCT/US2012/034456

Publication Date:

May 01, 2014

Filing Date:

April 20, 2012

Export Citation:

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Assignee:

UNIV ROCKEFELLER (US)
FISCHETTI VINCENT A (US)
SCHMITZ JONATHAN (US)
GILMER DANIEL (US)
EULER CHAD (US)

International Classes:

A61K38/16; A61P31/04

Foreign References:

US20100172918A1	2010-07-08
US20100310522A1	2010-12-09
US20070025978A1	2007-02-01
US20100004321A1	2010-01-07
US20100047222A1	2010-02-25

Other References:

FISCHETTI: "Bacteriophage lysins as effective antibacterials.", CURR. OPIN. MICROBIOL., vol. 11, no. 5, October 2008 (2008-10-01), pages 393 - 400, XP025613340

Attorney, Agent or Firm:

DIETZEL, Christine, E. (25 East Spring Valley Avenue - Suite 160Maywood, NJ, US)

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