Title:
STRESS INDUCED MUTATIONS AS A HALLMARK OF CANCER
Document Type and Number:
WIPO Patent Application WO/2018/067886
Kind Code:
A3
Abstract:
Omics signatures for stress-induced mutagenesis in cancer and methods related to same are presented. Advantageously, signatures can be characterized and a score can be calculated to provide useful guidance for therapy not otherwise obtainable from omics data.
Inventors:
BUSSEY KIMBERLEY J (US)
CISNEROS LUIS (US)
CISNEROS LUIS (US)
Application Number:
PCT/US2017/055438
Publication Date:
August 02, 2018
Filing Date:
October 05, 2017
Export Citation:
Assignee:
NANTOMICS LLC (US)
International Classes:
G16B20/20; G16B45/00
Domestic Patent References:
| WO2016154493A1 | 2016-09-29 |
Other References:
BERTRAND, DENIS ET AL.: "Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles", NUCLEIC ACIDS RESEARCH, vol. 43, no. 7, 20 April 2015 (2015-04-20), pages 1 - 13, XP055358560
MACHERET, MORGANE ET AL.: "DNA replication stress as a hallmark of cancer", ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, vol. 10, 2015, pages 425 - 448, XP055524499
LEE, JUNE-KOO ET AL.: "Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies", ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, vol. 11, 22 February 2016 (2016-02-22), pages 283 - 312, XP055524501
YEOM, MINA ET AL.: "Effects of twelve germline missense variations on DNA lesion and G-quadruplex bypass activities of human DNA polymerase REV1", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 29, no. 3, 25 February 2016 (2016-02-25), pages 367 - 379, XP055524504
CISNEROS, LUIS ET AL.: "Ancient genes establish stress-induced mutation as a hallmark of cancer", PLOS ONE, vol. 12, no. 4, 25 April 2017 (2017-04-25), pages 1 - 22, XP055524506
MACHERET, MORGANE ET AL.: "DNA replication stress as a hallmark of cancer", ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, vol. 10, 2015, pages 425 - 448, XP055524499
LEE, JUNE-KOO ET AL.: "Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies", ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, vol. 11, 22 February 2016 (2016-02-22), pages 283 - 312, XP055524501
YEOM, MINA ET AL.: "Effects of twelve germline missense variations on DNA lesion and G-quadruplex bypass activities of human DNA polymerase REV1", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 29, no. 3, 25 February 2016 (2016-02-25), pages 367 - 379, XP055524504
CISNEROS, LUIS ET AL.: "Ancient genes establish stress-induced mutation as a hallmark of cancer", PLOS ONE, vol. 12, no. 4, 25 April 2017 (2017-04-25), pages 1 - 22, XP055524506
Attorney, Agent or Firm:
FESSENMAIER, Martin et al. (US)
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