Title:
STROKE POLYGENIC RISK SCORE AND PATHOGENESIS RISK EVALUATION DEVICE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/179637
Kind Code:
A1
Abstract:
Provided are a stroke polygenic risk score (PRS) and a pathogenesis risk evaluation device and an application thereof. Specifically, provided is an application of a reagent, which is used for detecting individual information, in preparation of a detection device for evaluating a pathogenesis risk of stroke, wherein the individual information comprises 280 Stroke-related single nucleotide polymorphism sites. The individual information preferably further comprises one or more of CAD, SBP, WC, T2D, TC, PP, and AF-related single nucleotide polymorphism sites. The PRS and a traditional risk factor are further integrated, so that re-stratification of the pathogenesis risk of stroke can be achieved, and important significance for primary prevention of stroke is achieved.
Inventors:
LU XIANGFENG (CN)
GU DONGFENG (CN)
HUANG JIANFENG (CN)
LI HONGFAN (CN)
NIU XIAOGE (CN)
GU DONGFENG (CN)
HUANG JIANFENG (CN)
LI HONGFAN (CN)
NIU XIAOGE (CN)
Application Number:
PCT/CN2022/078254
Publication Date:
September 01, 2022
Filing Date:
February 28, 2022
Export Citation:
Assignee:
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCIENCES AND PEKING UNION MEDICAL COLLEGE (CN)
International Classes:
C12Q1/68
Foreign References:
| CN101760530A | 2010-06-30 | |||
| CN110257499A | 2019-09-20 | |||
| US20040014099A1 | 2004-01-22 | |||
| US20140142060A1 | 2014-05-22 | |||
| CN113046429A | 2021-06-29 |
Other References:
HUANG SULI, ZHOU SHIQUAN, ZHANG YANWEI, LV ZIQUAN, LI SHANSHAN, XIE CHANGHUI, KE YUEBIN, DENG PINGJIAN, GENG YIJIE, ZHANG QIAN, CH: "Association of the Genetic Polymorphisms in Pre-MicroRNAs with Risk of Ischemic Stroke in a Chinese Population", PLOS ONE, vol. 10, no. 2, 6 February 2015 (2015-02-06), pages e0117007, XP055961855, DOI: 10.1371/journal.pone.0117007
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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