Title:
STRONGLY HYDROPHILIC MICRONEEDLE SUBSTRATE AND DRUG-LOADED MICRONEEDLE AND USE THEREOF IN TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/279893
Kind Code:
A1
Abstract:
A microneedle made of a strongly hydrophilic substrate. A composition of polyvinyl alcohol and a small molecule polyhydroxy compound is used as a substrate to prepare a microneedle having a strongly hydrophilic surface and a drug-loaded microneedle. The microneedle having the strongly hydrophilic surface can be obtained by means of the compatibility of a polyhydroxy polymer polyvinyl alcohol and a small molecule polyhydroxy compound, and can strongly adsorb a drug as long as the microneedle is in contact with the drug; the drug does not easily shed, the process is simple, and mass production is facilitated; the drug loading capacity is significantly increased, and the drug use efficiency is high; the preparation of a blank microneedle and the drug loading are carried out in stages and the drug loading stage avoids the use of a high temperature; and the microneedle can be effectively applied to drug loading and drug release in the treatment of diseases, and mass production is facilitated. By means of the microneedle substrate composition, the blank microneedle prepared therefrom and the use of the blank microneedle in drug loading, the inherent surface strongly hydrophilic polarity of polyvinyl alcohol is maintained, so that the drug loading capacity and the in-vivo penetration capacity of the encapsulated drug loading are significantly increased.
Inventors:
YIN ZHONG (CN)
Application Number:
PCT/CN2022/096295
Publication Date:
January 12, 2023
Filing Date:
May 31, 2022
Export Citation:
Assignee:
YIN ZHONG (CN)
International Classes:
A61M37/00; A61K9/00; A61K38/22; A61K38/28; A61K45/00; A61K47/10; A61K47/26; A61K47/32; A61P3/10
Domestic Patent References:
| WO2003035363A1 | 2003-05-01 |
Foreign References:
| CN113426004A | 2021-09-24 | |||
| CN111087725A | 2020-05-01 | |||
| CN111116939A | 2020-05-08 | |||
| CN111298281A | 2020-06-19 | |||
| CN209500524U | 2019-10-18 | |||
| US20080269685A1 | 2008-10-30 | |||
| CN105078880A | 2015-11-25 | |||
| CN109414575A | 2019-03-01 |
Other References:
JIANG, XIANCAI ET AL.: "Research Progress in the Thermal Degradation of Poly (vinyl alcohol) and Modifications for Thermoplastic Processing", POLYMER BULLETIN, no. 10, 31 October 2010 (2010-10-31), pages 38 - 45, XP093022072
ZHONG MINGQIANGFAN PING: "Preparation and Performance Research of PVA with High Decomposition Temperature", MASTER'S THESIS OF ZHEJIANG UNIVERSITY OF TECHNOLOGY, SCHOOL OF MATERIALS SCIENCE AND ENGINEERING, January 2019 (2019-01-01)
ZHONG MINGQIANGFAN PING: "Preparation and Performance Research of PVA with High Decomposition Temperature", MASTER'S THESIS OF ZHEJIANG UNIVERSITY OF TECHNOLOGY, SCHOOL OF MATERIALS SCIENCE AND ENGINEERING, January 2019 (2019-01-01)
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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