Title:
STRUCTURE BASED DESIGN OF D-PROTEIN LIGANDS
Document Type and Number:
WIPO Patent Application WO/2017/072222
Kind Code:
A9
Abstract:
A method of designing a D-polypeptide that binds with an L-target protein can include: identifying a polypeptide target having L-chirality; determining hotspot amino acids of a polypeptide ligand having L-chirality that have binding interactions with the L-target protein; determining transformations of side chains of the hotspot amino acids that retain the binding interactions with the target; generating inversed hotspot amino acids with chirality opposite to the one of the target; identifying a polypeptide having inverse chirality from the target protein, on which a combination of inversed hotspot amino-acid can be grafted without significantly changing their interactions with the target. The designed ligands can be processed and converted to D-ligands that bind with the L-target protein.
Inventors:
JURASZEK JAROSLAW (NL)
BRANDUARDI DAVIDE (NL)
VOGELS RONALD (NL)
FRIESEN ROBERT (NL)
BRANDUARDI DAVIDE (NL)
VOGELS RONALD (NL)
FRIESEN ROBERT (NL)
Application Number:
PCT/EP2016/075916
Publication Date:
May 11, 2018
Filing Date:
October 27, 2016
Export Citation:
Assignee:
JANSSEN VACCINES & PREVENTION BV (NL)
International Classes:
G06F19/00; G16B15/30; G16B20/30; G16B20/50
Attorney, Agent or Firm:
MANTEN, Annemieke et al. (NL)
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