Title:
STUDY, DETERMINATION OR EVALUATION METHOD
Document Type and Number:
WIPO Patent Application WO/2008/029836
Kind Code:
A1
Abstract:
Disclosed is a method for the study, determination or evaluation of a pharmacological activity (e.g., an activity on fibromyalgia, an analgetic activity, an anti-stress activity) of a substance of interest by administering the substance to a SART-stressed animal and conducting the expression proteome analysis of a brain tissue of the animal. It becomes possible to search for a substance effective for fibromyalgia or a painful disease or an anti-stress substance by conducting the expression proteome analysis of a substance of interest with respect to how the substance affects the change in protein expression occurring in a brain tissue of a SART-stressed animal, or the like.
Inventors:
NISHIOKA KUSUKI (JP)
KATO TOMOHIRO (JP)
FUJISAWA HIROKI (JP)
KATO TOMOHIRO (JP)
FUJISAWA HIROKI (JP)
Application Number:
PCT/JP2007/067291
Publication Date:
March 13, 2008
Filing Date:
September 05, 2007
Export Citation:
Assignee:
UNIV SCHOOL ST MARIANNA (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NISHIOKA KUSUKI (JP)
KATO TOMOHIRO (JP)
FUJISAWA HIROKI (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NISHIOKA KUSUKI (JP)
KATO TOMOHIRO (JP)
FUJISAWA HIROKI (JP)
International Classes:
C12Q1/02; A61K35/36; A61K45/00; A61P21/00; A61P25/00; A61P25/04; A61P25/18; A61P29/00; G01N21/64; G01N27/447; G01N33/15; G01N33/50; G01N33/68
Domestic Patent References:
| WO2006095674A1 | 2006-09-14 | |||
| WO2004039383A1 | 2004-05-13 |
Other References:
HATA T. ET AL.: "Changes in CNS levels of serotonin and its metabolite in SART-stressed (Repeatedly cold-stressed) rats", JPN. J. PHARMACOL., vol. 56, 1991, pages 101 - 104, XP003002844
SÖLLNER T. AND ROTHMAN J.E.: "Neurotransmission: harnessing fusion machinery at the synapse", TRENDS NEUROSCI., vol. 17, no. 8, 1994, pages 344 - 348, XP003021654
ISHIDA Y.: "Proteomics ni Okeru Tanpakushitsu Hatsugen Differential Kaiseki -Keiko Hyoshiki Nijigen Difference Denki Eido: Ettan DIGE", CLINICAL TESTING, vol. 47, no. 11, 2003, pages 1269 - 1276, XP003002845
NISHIOKA K.: "Sen'ikintsusho no Kenkyu no Shinpo", INFLAMMATION & IMMUNOLOGY, vol. 12, no. 6, 2004, pages 2 - 6, XP003021655
KAWAMURA M. ET AL.: "Neurotropin no Chintsu Sayo Kijo -Gekosei Totsu Yokusei-kei o Chushin ni shite-", BRAIN, vol. 4, no. 2, 2001, pages 71 - 76, XP003002847
HATA T. ET AL.: "Plasma catecholamine levels in SART-stressed rats and effects of drugs on stress-induced alteration in plasma and brain catecholamine levels", J. AUTON. PHARMACOL., vol. 11, 1991, pages 15 - 25, XP003021656
SÖLLNER T. AND ROTHMAN J.E.: "Neurotransmission: harnessing fusion machinery at the synapse", TRENDS NEUROSCI., vol. 17, no. 8, 1994, pages 344 - 348, XP003021654
ISHIDA Y.: "Proteomics ni Okeru Tanpakushitsu Hatsugen Differential Kaiseki -Keiko Hyoshiki Nijigen Difference Denki Eido: Ettan DIGE", CLINICAL TESTING, vol. 47, no. 11, 2003, pages 1269 - 1276, XP003002845
NISHIOKA K.: "Sen'ikintsusho no Kenkyu no Shinpo", INFLAMMATION & IMMUNOLOGY, vol. 12, no. 6, 2004, pages 2 - 6, XP003021655
KAWAMURA M. ET AL.: "Neurotropin no Chintsu Sayo Kijo -Gekosei Totsu Yokusei-kei o Chushin ni shite-", BRAIN, vol. 4, no. 2, 2001, pages 71 - 76, XP003002847
HATA T. ET AL.: "Plasma catecholamine levels in SART-stressed rats and effects of drugs on stress-induced alteration in plasma and brain catecholamine levels", J. AUTON. PHARMACOL., vol. 11, 1991, pages 15 - 25, XP003021656
Attorney, Agent or Firm:
FUJII, Ikuro (Legal Management Division, 1-2, Hiranomachi 2-chome, Chuo-ku,Osaka-sh, Osaka 46, JP)
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