Title:
STUDY ON LACTOFERRIN REGULATION OF BONE FORMATION BY MEANS OF VITAMIN D RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2019/227421
Kind Code:
A1
Abstract:
A use of lactoferrin in the preparation of a food or drug, the food or drug being used for activating a VDR signaling pathway, which is used for the treatment of bone disease, bone disease comprising: osteoporosis, bone damage, loss of bone calcium, incomplete bone development and bone abnormalities. The present invention further comprises screening for drugs that are used to promote osteoblast proliferation and differentiation by using an active state of the VDR signaling pathway.
Inventors:
GUO HUIYUAN (CN)
LI YIXUAN (CN)
ZHANG HAO (CN)
ZHAO LIANG (CN)
LI YIXUAN (CN)
ZHANG HAO (CN)
ZHAO LIANG (CN)
Application Number:
PCT/CN2018/089332
Publication Date:
December 05, 2019
Filing Date:
May 31, 2018
Export Citation:
Assignee:
UNIV CHINA AGRICULTURAL (CN)
International Classes:
A61K38/40; A23L33/155; A23L33/17; A61K31/59; A61P19/08; A61P19/10; C12Q1/02
Foreign References:
| CN108671225A | 2018-10-19 | |||
| CN105399816A | 2016-03-16 |
Other References:
DU, DANDAN ET AL.: "Effect of Bovine Lactoferrin on the Bone Metabolism in Ovariectomized Rats", FUJIAN MEDICAL JOURNAL, vol. 33, no. 2, 30 April 2011 (2011-04-30), pages 5 - 8
CHEN, XIAXIA ET AL.: "The Best Concentration and the Best Time of Lactoferrin for the Stimulation of Osteoblast Proliferation and Differentiation", CHINESE JOURNAL OF OSTEOPOROSIS, vol. 21, no. 2, 28 February 2015 (2015-02-28), pages 142 - 146
CHEN, SHIJING ET AL.: "The Present Condition of Drug Therapy on Osteoporosis", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, vol. 18, no. 2, 30 April 2001 (2001-04-30), pages 87 - 90
HOU, JIANMING ET AL.: "Bovine Lactoferrin Improves Bone Mass and Microstructure in Ovariectomized Rats via OPG/RANKL/RANK Pathway", ACTA PHARMACOLOGICA SINICA, vol. 33, no. 10, 20 August 2012 (2012-08-20) - October 2012 (2012-10-01), pages 1277 - 1284, XP055660403
CHEN, XIAXIA ET AL.: "The Best Concentration and the Best Time of Lactoferrin for the Stimulation of Osteoblast Proliferation and Differentiation", CHINESE JOURNAL OF OSTEOPOROSIS, vol. 21, no. 2, 28 February 2015 (2015-02-28), pages 142 - 146
CHEN, SHIJING ET AL.: "The Present Condition of Drug Therapy on Osteoporosis", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, vol. 18, no. 2, 30 April 2001 (2001-04-30), pages 87 - 90
HOU, JIANMING ET AL.: "Bovine Lactoferrin Improves Bone Mass and Microstructure in Ovariectomized Rats via OPG/RANKL/RANK Pathway", ACTA PHARMACOLOGICA SINICA, vol. 33, no. 10, 20 August 2012 (2012-08-20) - October 2012 (2012-10-01), pages 1277 - 1284, XP055660403
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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