Title:
SUBMUCOSA MODULATION OF MAMMALIAN IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO/2000/032209
Kind Code:
A2
Abstract:
A composition and method for locally suppressing the cell mediated immune response of a vertebrate species is described. The method comprises contacting the site in need of immune suppression with a composition comprising vertebrate submucosa.
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Inventors:
BADYLAK STEPHEN F (US)
MCPHERSON TIMOTHY B (US)
METZGER DENNIS (US)
MCPHERSON TIMOTHY B (US)
METZGER DENNIS (US)
Application Number:
PCT/US1999/028302
Publication Date:
June 08, 2000
Filing Date:
December 01, 1999
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION (US)
MEDICAL COLLEGE OF OHIO AT TOL (US)
BADYLAK STEPHEN F (US)
MCPHERSON TIMOTHY B (US)
METZGER DENNIS (US)
MEDICAL COLLEGE OF OHIO AT TOL (US)
BADYLAK STEPHEN F (US)
MCPHERSON TIMOTHY B (US)
METZGER DENNIS (US)
International Classes:
A61K35/12; A61K35/34; A61K35/36; A61K35/38; A61P37/06; (IPC1-7): A61K35/38; A61K35/12; A61P37/06
Domestic Patent References:
| WO1990000395A1 | 1990-01-25 | |||
| WO1994011008A1 | 1994-05-26 | |||
| WO1999012555A1 | 1999-03-18 |
Attorney, Agent or Firm:
Lammert, Steven R. (IN, US)
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Claims:
CLAIMS:
| 1. | A method for locally suppressing the cell mediated immune response in a vertebrate species, said method comprising the steps of contacting a site in need of immune suppression with an effective amount of a composition comprising vertebrate submucosa. |
| 2. | The method of claim 1 wherein the submucosa is intestinal submucosa comprising the tunica submucosa delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa of vertebrate intestine. |
| 3. | The method of claim 1 wherein the submucosa tissue is treated with galactosidase to be substantially free of the Gal epitope. |
| 4. | The method of claim 1, wherein the submucosa is fluidized submucosa. |
| 5. | The method of claim 4, wherein the submucosa is digested with an enzyme for a period of time sufficient to solubilize the tissue. |
| 6. | A method of protecting immunogenic biomaterial from the immune system of a host organism said method comprising the step of encapsulating the biomaterial within a composition comprising vertebrate submucosa and implanting the composition into the host organism. |
| 7. | The method of claim 6 wherein the composition comprises intestinal submucosa delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa of vertebrate intestine. |
| 8. | The use of vertebrate submucosa in the manufacture of a pharmaceutical composition for the suppression of a cell mediated immune response in a vertebrate species. |
| 9. | The use according to claim 8 wherein the pharmaceutical composition is used to treat an autoimmune disorder. |
Description:
INTERNATIONALSEARCHREPORT Intee anal AppilcatlonNo informationonpatent tamily members PatentdocumentPublication Patent family Publication citedinsearchreportdate member(s)date WO9000395A25-01-1990US 4902508 A 20-02-1990 AT 112963 T 15-11-1994 AU 613499 B 01-08-1991 AU 3709189 A 11-01-1990 BR 8907538 A 11-06-1991 CA 1335432 A 02-05-1995 CH 681506 A 15-04-1993 CH 681856 A 15-06-1993 CN 1039352A,B 07-02-1990 DE 68918943 D 24-11-1994 DE 68918943 T 08-06-1995 DK 340589 A 12-01-1990 EP 0424463 A 02-05-1991 ES 2019146 A 01-06-1991 HU 207448 B 28-04-1993 IE 67279 B 20-03-1996 IL 90622 A 24-06-1994 JP 2539934 B 02-10-1996 JP 4501516 T 19-03-1992 KR 131821 B 17-04-1998 MX 171671 B 10-11-1993 NO 910090 A 09-01-1991 NZ 229797 A 25-09-1991 OA 9633 A 30-04-1993 PH 26921 A 03-12-1992 PT 91096A,B 08-02-1990 RU 2037317 C 19-06-1995 US 4956178 A 11-09-1990 ZA 8904551 A 28-03-1990 WO9411008A26-05-1994US 5275826 A 04-01-1994 AT 192654 T 15-05-2000 AU 677974 B 15-05-1997 AU 5552394 A 08-06-1994 BR 9307419 A 31-08-1999 CA 2149324 A 26-05-1994 CZ 9501240 A 15-11-1995 DE 69328625 D 15-06-2000 EP 0671922 A 20-09-1995 FI 952337 A 12-05-1995 HU 73965 A 28-10-1996 JP 8506799 T 23-07-1996 MX 9307046 A 31-01-1995 NO 951881 A 12-05-1995 NZ 258032 A 26-05-1997 PL 309000 A 18-09-1995 SK 61095 A 08-11-1995 US 5516533 A 14-05-1996 US 5641518 A 24-06-1997 WO9912555A18-03-1999AU 9385298 A 29-03-1999 EP 1011699 A 28-06-2000