Title:
SUBNANOMOLAR PRECIPITATOR OF THIOPHILIC METALS
Document Type and Number:
WIPO Patent Application WO2006055883
Kind Code:
A3
Abstract:
A fluorescent dye-doped crystalline assay is employed for selection and detection of thiophilic heavy metal ions. While comparable in analytical performance to known solution based methodologies, the formation of crystalline analytes provides for signal amplification, and consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems. In a microcapillary format, this assay is capable of screening hundreds of samples per day for the presence of subnanomolar concentrations of Hg2+ using a conventional fluorescence microscope.
Inventors:
JANDA KIM D (US)
DICKERSON TOBIN J (US)
LA CLAIR JAMES J (US)
DICKERSON TOBIN J (US)
LA CLAIR JAMES J (US)
Application Number:
PCT/US2005/042081
Publication Date:
October 12, 2006
Filing Date:
November 18, 2005
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
JANDA KIM D (US)
DICKERSON TOBIN J (US)
LA CLAIR JAMES J (US)
JANDA KIM D (US)
DICKERSON TOBIN J (US)
LA CLAIR JAMES J (US)
International Classes:
C07D333/62
Foreign References:
| US6403172B1 | 2002-06-11 | |||
| US5755875A | 1998-05-26 | |||
| US7018850B2 | 2006-03-28 | |||
| US5220036A | 1993-06-15 | |||
| US7067324B2 | 2006-06-27 |
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