Title:
SUBPOPULATIONS OF BONE MARROW-DERIVED ADHERENT STEM CELLS AND METHODS OF USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2009/058983
Kind Code:
A3
Abstract:
The presently disclosed subject matter provides an isolated subpopulation of bone marrow-derived adherent stem cells that are purified from bone marrow-derived adherent cells. Also provided are methods for isolating the subpopulation of bone marrow-derived adherent stem cells from bone marrow-derived adherent cells and for using the isolated subpopulation of bone marrow-derived adherent stem cells for treating tissue and/or organ damage in a subject.
Inventors:
ZUBA-SURMA EWA K (US)
DAWN BUDDHADEB (US)
ABDEL-LATIF AHMED (US)
BOLLI ROBERTO (US)
DAWN BUDDHADEB (US)
ABDEL-LATIF AHMED (US)
BOLLI ROBERTO (US)
Application Number:
PCT/US2008/081761
Publication Date:
November 25, 2010
Filing Date:
October 30, 2008
Export Citation:
Assignee:
UNIV LOUISVILLE RES FOUND (US)
ZUBA-SURMA EWA K (US)
DAWN BUDDHADEB (US)
ABDEL-LATIF AHMED (US)
BOLLI ROBERTO (US)
ZUBA-SURMA EWA K (US)
DAWN BUDDHADEB (US)
ABDEL-LATIF AHMED (US)
BOLLI ROBERTO (US)
International Classes:
C12N5/077; A61K35/28; C12N5/0775; A61K35/12
Foreign References:
| US20090110668A1 | 2009-04-30 |
Other References:
ZUBA-SURMA EWA K ET AL: "Antigenically-defined subsets of bone marrow mesenchymal stem cells exhibit differential cardionnyogenic and angiogenic potential", CIRCULATION, vol. 114, no. 18, Suppl. S, October 2006 (2006-10-01), & 79TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; CHICAGO, IL, USA; NOVEMBER 12 -15, 2006, pages 170, XP009139197, ISSN: 0009-7322
ZUBA-SURMA E K ET AL: "Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB LNKD- DOI:10.1016/J.YJMCC.2006.07.011, vol. 41, no. 4, 1 October 2006 (2006-10-01), pages 650 - 660, XP024949777, ISSN: 0022-2828, [retrieved on 20061001]
GOJO S ET AL: "In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US LNKD- DOI:10.1016/S0014-4827(03)00132-0, vol. 288, 1 January 2003 (2003-01-01), pages 51 - 59, XP003004044, ISSN: 0014-4827
ABDEL-LATIF A ET AL: "Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis", ARCHIVES OF INTERNAL MEDICINE, AMERICAN MEDICAL ASSOCIATION, CHICAGO, IL, US LNKD- DOI:10.1001/ARCHINTE.167.10.989, vol. 167, no. 10, 28 May 2007 (2007-05-28), pages 989 - 997, XP002528913, ISSN: 0003-9926
DUFF SARAH E ET AL: "CD105 is important for angiogenesis: Evidence and potential applications.", FASEB JOURNAL, vol. 17, no. 9, June 2003 (2003-06-01), pages 984 - 992 URL, XP009139193, ISSN: 0892-6638
RATAJCZAK MARIUSZ Z ET AL: "Bone-marrow-derived stem cells - our key to longevity?", JOURNAL OF APPLIED GENETICS, vol. 48, no. 4, 21 September 2007 (2007-09-21), pages 307 - 319, XP002602321, ISSN: 1234-1983
ZUBA-SURMA E K ET AL: "Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB LNKD- DOI:10.1016/J.YJMCC.2006.07.011, vol. 41, no. 4, 1 October 2006 (2006-10-01), pages 650 - 660, XP024949777, ISSN: 0022-2828, [retrieved on 20061001]
GOJO S ET AL: "In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US LNKD- DOI:10.1016/S0014-4827(03)00132-0, vol. 288, 1 January 2003 (2003-01-01), pages 51 - 59, XP003004044, ISSN: 0014-4827
ABDEL-LATIF A ET AL: "Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis", ARCHIVES OF INTERNAL MEDICINE, AMERICAN MEDICAL ASSOCIATION, CHICAGO, IL, US LNKD- DOI:10.1001/ARCHINTE.167.10.989, vol. 167, no. 10, 28 May 2007 (2007-05-28), pages 989 - 997, XP002528913, ISSN: 0003-9926
DUFF SARAH E ET AL: "CD105 is important for angiogenesis: Evidence and potential applications.", FASEB JOURNAL, vol. 17, no. 9, June 2003 (2003-06-01), pages 984 - 992 URL, XP009139193, ISSN: 0892-6638
RATAJCZAK MARIUSZ Z ET AL: "Bone-marrow-derived stem cells - our key to longevity?", JOURNAL OF APPLIED GENETICS, vol. 48, no. 4, 21 September 2007 (2007-09-21), pages 307 - 319, XP002602321, ISSN: 1234-1983
Attorney, Agent or Firm:
TAYLOR, Arles, A. Jr. (Wilson Taylor & Hunt, P.A.,Suite 1200, University Tower,3100 Tower Boulevar, Durham NC, US)
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