SUBSITUTED SULPHONAMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND THEIR USE

Title:

SUBSITUTED SULPHONAMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND THEIR USE

Document Type and Number:

WIPO Patent Application WO2008130332

Kind Code:

B1

Abstract:

Substituted sulphonamides having the general formula (I) and salts, hydrates and solvates thereof were prepared and described, wherein R1 isCO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain and n represents number of linking aliphatic chain carbons (n can be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due to the carboanhydrase inhibition. These compounds are prepared by nucleophilic reaction of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presence of triethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20 °C. The compounds show an antiglaucomatic activity.

Inventors:

GREGAN FRIDRICH (SK)
REMKO MILAN (SK)
SLUCIAKOVA ELENA (SK)
KNAPIKOVA JARMILA (SK)

Application Number:

PCT/SK2008/050005

Publication Date:

December 18, 2008

Filing Date:

April 18, 2008

Export Citation:

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Assignee:

UNIMED PHARMA SPOL SRO (SK)
GREGAN FRIDRICH (SK)
REMKO MILAN (SK)
SLUCIAKOVA ELENA (SK)
KNAPIKOVA JARMILA (SK)

International Classes:

C07C311/16; A61K31/18; A61K31/40; A61K31/5375; A61P27/06; C07C311/18; C07D207/12; C07D295/12

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