Title:
SUBSTANCE MEASUREMENT METHOD FOR MEASURING SUBSTANCE TO BE MEASURED AS COENZYME
Document Type and Number:
WIPO Patent Application WO/2018/216757
Kind Code:
A1
Abstract:
At least an enzyme that takes a substance to be measured contained in a sample as a coenzyme and a substrate of the enzyme are added to a sample, a product produced by a chemical reaction catalyzed by the enzyme is measured, and the substance to be measured contained in the sample is quantified on the basis of the amount of product measured. If the substance to be measured is thiamine, pyruvate oxidase, for example, is used as the enzyme; pyruvic acid is added as the substrate, and a cofactor other than the substance to be measured is added as needed to induce a chemical reaction. The thiamine can be quantified by measuring hydrogen peroxide among the products by a known method.
Inventors:
BABA TOSHIAKI
NISHIYA YOSHIAKI
NISHIYA YOSHIAKI
Application Number:
PCT/JP2018/019939
Publication Date:
November 29, 2018
Filing Date:
May 24, 2018
Export Citation:
Assignee:
NIPRO CORP (JP)
International Classes:
C12Q1/26; G01N33/82
Foreign References:
| JPH02200200A | 1990-08-08 | |||
| JPH1189594A | 1999-04-06 | |||
| JPS6368099A | 1988-03-26 | |||
| JP2003057235A | 2003-02-26 | |||
| JPH08168397A | 1996-07-02 |
Other References:
SCHUBERT, FLORIAN ET AL.: "Lactate-Dehydrogenase- Based Biosensors for Glyoxylate and NADH Determination: A Novel Principle of Analyte Recycling", ELECTROANALYSIS, vol. 2, no. 5, July 1990 (1990-07-01), pages 347 - 351, XP055563671
AKYILMAZ, EROL ET AL.: "A novel biosensor based on activation effect of thiamine on the activity of pyruvate oxidase", BIOSENSORS AND BIOELECTRONICS, vol. 23, no. 12, 14 March 2008 (2008-03-14), pages 1874 - 1877, XP022666056
EDWARDS, KATIE A. ET AL.: "Thiamine Assays- Advances, Challenges, and Caveats", CHEMISTRYOPEN, vol. 6, no. 2, 8 March 2017 (2017-03-08), pages 178 - 191, XP055472007
ASANUMA, KAZUKO ET AL.: "Simultaneous quantification method by automatic analysis of lactic acid and pyruvic acid in blood plasma using oxidase system", ANALYSIS OF CLINICAL SPECIMEN, vol. 8, no. 3, 1985, pages 16 - 24
MIZOGUCHI, MAKOTO ET AL.: "The development of new type oxidative and reductive chromogenic reagents in clinical analysis", BUNSEKI KAGAKU, vol. 45, no. 2, 1996, pages 111 - 124, XP055563676
SAKAKIBARA, KANAKO ET AL.: "A Sensitive Enzymatic Cycling Method for Determination of Lactate and Pyruvate in Blood", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 29, no. 2, 2000, pages 69 - 73, XP055563680
AKYILMAZ, EROL ET AL.: "A novel biosensor based on activation effect of thiamine on the activity of pyruvate oxidase", BIOSENSORS AND BIOELECTRONICS, vol. 23, no. 12, 14 March 2008 (2008-03-14), pages 1874 - 1877, XP022666056
EDWARDS, KATIE A. ET AL.: "Thiamine Assays- Advances, Challenges, and Caveats", CHEMISTRYOPEN, vol. 6, no. 2, 8 March 2017 (2017-03-08), pages 178 - 191, XP055472007
ASANUMA, KAZUKO ET AL.: "Simultaneous quantification method by automatic analysis of lactic acid and pyruvic acid in blood plasma using oxidase system", ANALYSIS OF CLINICAL SPECIMEN, vol. 8, no. 3, 1985, pages 16 - 24
MIZOGUCHI, MAKOTO ET AL.: "The development of new type oxidative and reductive chromogenic reagents in clinical analysis", BUNSEKI KAGAKU, vol. 45, no. 2, 1996, pages 111 - 124, XP055563676
SAKAKIBARA, KANAKO ET AL.: "A Sensitive Enzymatic Cycling Method for Determination of Lactate and Pyruvate in Blood", JAPANESE JOURNAL OF CLINICAL CHEMISTRY, vol. 29, no. 2, 2000, pages 69 - 73, XP055563680
Attorney, Agent or Firm:
PATENT CORPORATE BODY ARCO PATENT OFFICE (JP)
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