Title:
SUBSTITUTED 1, 3, 5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS
Document Type and Number:
WIPO Patent Application WO2002046172
Kind Code:
A3
Abstract:
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
Inventors:
CAMPBELL MICHAEL
ZABLOCKI JEFF A
IBRAHIM PRABHA N
ZABLOCKI JEFF A
IBRAHIM PRABHA N
Application Number:
PCT/US2001/046387
Publication Date:
February 06, 2003
Filing Date:
December 03, 2001
Export Citation:
Assignee:
CV THERAPEUTICS INC (US)
International Classes:
A61K31/085; A61K31/136; A61K31/16; A61K31/165; A61K31/167; A61K31/17; A61K31/18; A61K31/357; A61K31/435; A61K31/47; A61K31/472; A61K31/495; A61K31/505; A61K31/506; A61K45/00; A61K31/53; A61K45/06; A61P3/06; A61P9/00; A61P9/10; A61P43/00; C07C237/04; C07C237/06; C07C237/22; C07C237/40; C07C275/26; C07C311/20; C07C323/36; C07C323/40; C07C323/60; C07C327/42; C07C327/44; C07C327/48; C07C335/16; C07D215/38; C07D217/24; C07D239/48; C07D251/16; C07D251/22; C07D251/52; C07D319/08; C07D319/18; C07D401/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D413/14; (IPC1-7): C07D239/48; C07D251/20; C07D251/46; C07D251/52; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D413/14; A61K31/505; A61K31/53; A61P9/10
Domestic Patent References:
| WO2001047897A1 | 2001-07-05 | |||
| WO2000043369A1 | 2000-07-27 |
Foreign References:
| DE19536891A1 | 1997-04-10 | |||
| US4559345A | 1985-12-17 | |||
| US6150362A | 2000-11-21 | |||
| DE1220860B | 1966-07-14 |
Other References:
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203489
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203490
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203491
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203492
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203493
CHEMICAL ABSTRACTS, vol. 72, no. 13, 1970, Columbus, Ohio, US; abstract no. 66998z, MUELLER, Z. ET AL.: "Furylaminotriazines which promote the growth of plants" page 410; XP002203487
CHEMICAL ABSTRACTS, vol. 72, no. 13, 1970, Columbus, Ohio, US; abstract no. 67000e, KUROKI, N. ET AL.: "Triazine compounds" page 410; XP002203488
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203494
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203495
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203496
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203497
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203498
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203499
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203500
FALCH E ET AL: "SUBSTITUTED HETEROAROMATIC ANTHRANILIC ACIDS WITH ANTIINFLAMMATORY ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 3, no. 11, May 1968 (1968-05-01), pages 608 - 611, XP001069203, ISSN: 0022-2623
WARD A D ET AL: "IRREVERSIBLE ENZYME INHIBITORS 200.1 ACTIVE-SITE-DIRECTED INHIBITORS OF DEOXYCYTIDINE KINASE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 20, no. 1, 1977, pages 88 - 92, XP000575955, ISSN: 0022-2623
DATABASE CHEMCATS Chemical Abstract Service, Columbus, Ohio, US, retrieved from STN; XP002203501
SCHWARTZ K ET AL: "ABC1 GENE EXPRESSION AND APOA-I-MEDIATED CHOLESTER0L EFFLUX ARE REGULATED BY LXR", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 274, no. 3, 11 August 2000 (2000-08-11), pages 794 - 802, XP000960872, ISSN: 0006-291X
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203490
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203491
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203492
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203493
CHEMICAL ABSTRACTS, vol. 72, no. 13, 1970, Columbus, Ohio, US; abstract no. 66998z, MUELLER, Z. ET AL.: "Furylaminotriazines which promote the growth of plants" page 410; XP002203487
CHEMICAL ABSTRACTS, vol. 72, no. 13, 1970, Columbus, Ohio, US; abstract no. 67000e, KUROKI, N. ET AL.: "Triazine compounds" page 410; XP002203488
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203494
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203495
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203496
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203497
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203498
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203499
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002203500
FALCH E ET AL: "SUBSTITUTED HETEROAROMATIC ANTHRANILIC ACIDS WITH ANTIINFLAMMATORY ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 3, no. 11, May 1968 (1968-05-01), pages 608 - 611, XP001069203, ISSN: 0022-2623
WARD A D ET AL: "IRREVERSIBLE ENZYME INHIBITORS 200.1 ACTIVE-SITE-DIRECTED INHIBITORS OF DEOXYCYTIDINE KINASE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 20, no. 1, 1977, pages 88 - 92, XP000575955, ISSN: 0022-2623
DATABASE CHEMCATS Chemical Abstract Service, Columbus, Ohio, US, retrieved from STN; XP002203501
SCHWARTZ K ET AL: "ABC1 GENE EXPRESSION AND APOA-I-MEDIATED CHOLESTER0L EFFLUX ARE REGULATED BY LXR", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 274, no. 3, 11 August 2000 (2000-08-11), pages 794 - 802, XP000960872, ISSN: 0006-291X
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