Title:
SUBSTITUTED 1-(ISOXAZOLE-3-YL)-3-(3-FLUORINE-4-PHENYL)UREA DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/137610
Kind Code:
A1
Abstract:
A substituted 1-(isoxazole-3-yl)-3-(3-fluorine-4-phenyl)urea derivative, and a preparation method therefor and a use thereof, relating to the technical field of organic synthesis of medicines. A substituted 1-(isoxazole-3-yl)-3-(3-fluorine-4-phenyl)urea derivative is provided, and the structural formula thereof is as represented by formula (I). Also provided is a preparation method for the substituted 1-( isoxazole-3-yl)-3-(3- fluorine-4-phenyl)urea derivative, and a use in preparing an FMS-fins-like tyrosine kinase 3 inhibitor. The present invention provides a novel effective choice for preparation of kinase inhibitors, preparation of medicines for treating autoimmune diseases, and preparation of angiogenesis inhibitors and antitumor medicines in the art, and has a very good application prospect.
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Inventors:
YANG SHENGYONG (CN)
LI LINLI (CN)
LI LINLI (CN)
Application Number:
PCT/CN2018/073793
Publication Date:
August 02, 2018
Filing Date:
January 23, 2018
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07D471/04; A61K31/435; A61K31/506; A61K31/517; A61K31/519; A61P35/04; A61P37/02; C07D215/22; C07D401/14; C07D413/12; C07D491/056
Domestic Patent References:
| WO2012019015A2 | 2012-02-09 | |||
| WO2012008564A1 | 2012-01-19 |
Foreign References:
| CN103570723A | 2014-02-12 | |||
| CN105461709A | 2016-04-06 | |||
| CN101801383A | 2010-08-11 | |||
| CN1543459A | 2004-11-03 | |||
| US20090012091A1 | 2009-01-08 |
Other References:
CHEN, YIN ET AL.: "Integrated Bioinformatics, Computational and Experimental Methods to Discover Novel Raf/Extracellular-Signal Regulated Kinase (ERK) Dual Inhibitors Against Breast Cancer Cells", EUR. J. MED. CHEM., vol. 127, 8 November 2016 (2016-11-08), pages 997 - 1011, XP029907396, ISSN: 0223-5234
WU, XIAOYUN ET AL.: "Pyrrolo[3,2-d]pyrimidine Derivatives as Type II Kinase Insert Domain Receptor (KDR) Inhibitors: CoMFA and CoMSIA Studies", INT. J. MOL. SCI., vol. 13, 22 February 2012 (2012-02-22), pages 2387 - 2404, XP055525943, ISSN: 1422-0067
SHI, XIANGFEI ET AL.: "Design and Synthesis of Quinoline Derivatives as Protein Tyrosine Kinase Inhibitors", PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 27, no. 3, 20 June 2011 (2011-06-20), pages 189 - 192, ISSN: 1008-9926
WU, XIAOYUN ET AL.: "Pyrrolo[3,2-d]pyrimidine Derivatives as Type II Kinase Insert Domain Receptor (KDR) Inhibitors: CoMFA and CoMSIA Studies", INT. J. MOL. SCI., vol. 13, 22 February 2012 (2012-02-22), pages 2387 - 2404, XP055525943, ISSN: 1422-0067
SHI, XIANGFEI ET AL.: "Design and Synthesis of Quinoline Derivatives as Protein Tyrosine Kinase Inhibitors", PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 27, no. 3, 20 June 2011 (2011-06-20), pages 189 - 192, ISSN: 1008-9926
Attorney, Agent or Firm:
CHENGDU JUNHEJI PATENT OFFICE (ORDINARY PARTNERSHIP) (CN)
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