FREESTONE GRAEME (US)
GOMEZ LAURENT (US)
LEMUS ROBERT (US)
LY KIEV (US)
MCCARRICK MARGARET (US)
VERNIER WILLIAM (US)
VICKERS TROY (US)
| AMENDED CLAIMS received by the International Bureau on 10 November 2015 (10.1 1 .2015) What is claimed is: 1. of Formula (I) : (I) wherein X is -CH2- or ·()·. Y is -C I I - or -CF2~; Z is -( ί ! - or -C(=0)-; R1 is a member selected from the group consisting of: (a) phenyl unsubstituted or substituted with one, two, three, four, or five Ra members; where Ra is each independently selected from the group consisting of: -H, -halo, -Ci-ealkyl, -Ci-ehaloalkyl, -Ci-ealkoxy, -Ci-ehaloalkoxy, -CN, -N(Ci-6 lkyl)2, -SF5, -Cs-ecycloalkyl, -pyrrolidine, -morpholine, -piperidine, -pyrazoie, -furan, -imidazole, -thiophene, -thiazole, -pyridine, and -phenyl, wherein phenyl is unsubstituted or substituted with one, two, three, four, or five Rb members; where R is each independently selected from the group consisting of: -H, -CI and -F; or optionally two adjacent Ra members come together to form a ring, each optionally unsubstituted or substituted with one or more members independeniy selected from: -H, -halo, -Ci-eaikyl, or -Ci-ealkoxy; (b) monocyclic or bicyclic heteroaromatic ring each unsubstituted or substituted with one, two, three, or four members; where R° is each independently selected from the group consisting of: -H, -halo, -Ci-ealkyl, ~C1.4haioa.lkyl, -N(Ci.6a3kyl)2, -(Ci.6alkyl)cycloalkyl, -cyclopropyl, -morpholine, -pyrrolidine, -4-chlorophenoxy, and -phenyl optionally unsubstituted or substituted with -halo, -Ci.ealkyl, or and (c) heterocycloalkyl ring unsubstituted or substituted with one or more -H, -F, or -OCH3; and R2 is -Ci-ealkyl. 2. A chemical entity as in claim 1, wherein X is -O- and Y is -CH2~. 3. A chemical entity as in claim 1 , wherein X is ~CH2- and Y is -CF2-. 4. A chemical entity as in claim 1 , wherein X is ~CH2- and Y is -CH2-, 5. A chemical entity as in claim 1, wherein Z is -(¾-. 6. A chemical entity as in claim 1, wherein Z is -C(=0)-. 7, A chemical entity as in claim 1, wherein R is -CH3. 8. A chemical entity as in claim 1 , wherein R! is phenyl unsubstituted or substituted with one, two, three, four, or five Rd members. 9. A chemical entity as in claim 1, wherein R3 is a member independently selected from the group consisting of: -H, -halo, -Cj-ealkyl, -Ci-ehaloalkyl, -Ct-ealkoxy, -Ci-ehaloalkoxy, -CN, -N(Ci-6alkyl)2, and -C3-6cycloalkyl. 10. A chemical entity as in claim 1, wherein Ra is a member independently selected from: -H, -CI, -Br, -F, -I, -G. alkyl, -Ci.4haloalkyl, -C5.. aikoxy, -Ci..4haioalkoxy, -CN, -N(CH3)2, and -cyclopropyl. 11 . A chemical entity as in claim 1 , wherein Ra is a member independently selected from: -pyrrolidine, -morpholine, -piperidine, -pyrazole, -furan, -imidazole, -thiophene, -thiazole, -pyridine, or phenyl substituted with one or more -H, -CI, or -F. 12. A chemical entity as in claim 1, wherein R1 is naphthalen-l -yl, naphthalen-2-yl, 6- methoxynaphthalen-2-yl, l-methoxynaphthalen-2-yl, 3-methoxynaphthalen-2-yl, 3- methoxynaphthalene-2-yl, 6-fluoronaphthalen-2-yl, 5,6,7,8-tetrahydronaphthalen-2-yl, 5,6,7,8-tetrahydronaphthalene-2-yl, 2,3-dihydro-lH-inden-5-yl, 2,3-dihydro-lH-inden-5-yl, 2H-l,3-benzodioxol-4-yl, 2H-l,3-benzodioxol-5-yl, 2,3-dihydro-l,4-benzodioxin-6-yl, 2,2- difluoro-2H-l ,3-benzodioxol-5-yl, 1 -ethyl- l H-indole, indole, isoquinoline, 2,3-dihydro-l- benzofuran-5 -yl, 2 ,3 -dihydro- 1 -benzofuran-6-yl, 3 ,4-dihydro-2H- 1 -benzopy ran-6-yl, 1 - benzofuran, l-benzofuran-5-yl, l ,3-benzothiazol-6-yl, or l-benzothiophen-5-yl. 13. A chemical entity as in claim I, wherein R1 is l-( L3-thiazoi-2-yi)-lH-pyrrol-2-yi, l-(2- chlorophenyl)- lH-pyrazol-3-yl, 1 -(2-fluorophenyl)- lH-pyrazol-3-yl, 1 -(3-bromophenyl)- 1H- pyrazol-3-yl, l-(3-fluorophenyl)- lH-pyrazol-3-yl, l-(4-chiorophenyl)-5-methyl- lH-pyrazol- 3-yi, l-(4-fluorophenyl)-5-methyi-lH-pyrazo3-3-yl, l-(4-isopropylphenyl)-5-methyl- lH- pyrazol-3-yl, L3-benzotluazole, l,3-dimethyi-lH-pyrazoi-5-yl, l,5-dimethyl-lH-pyrazol-3-yl, l,5-dimethyl- lH-pyrazol-4-yi, 1 ,6-naphthyridin-2-yl, l-benzofuran-2-yl, l-benzofuran-3-yl, l-benzothiophen-2-yl, l-benzothiophen-3-yl, l-ethyi-lH-pyrazoi-5-yl, lH-indol-3-yl, 1- isopropyi- lH-pyrazoi-4-yl, 1 -methyl- lH-benzo[d]imidazol-2-yl, 1 -methyl- lH-indazol-3-yl, 1 - methyl- lH-indol-2-yl, 1 -methyl- lH-indol-3-yl, 1 -methyl-3-(propan-2-yl)- lH-pyrazole, 1 - methyl-3 -phenyl- lH-pyrazol-5 -yl, 1 -methyl-5 -phenyl - IH-pyrazol -3 -yl, 1 -phenyl- lH-pyrazol- 4-yl, 1 -phenyl- 1 H-pyrazol-4-yi, 2-{3 -fluorophenyl) - 1 ,3 -thiazol-5 -yljmethyl, 2-(3 - methoxyphenyl)-l,3-thiazol-5-yl, 2-(4-cli3oroplienoxy)pyridin~3~y3, 2-(4-fluorophenyl)-l,3- thiazol-5 -yl , 2-(py rrolidin- 1 -yl)- 1 ,3 -thiazol -5 -yl, 2,4-dimethylthiazol-5 -yl, 2,6- dimethylpyridin-3-yl, 2-bromo-l,3-thiazol-4-yl, 2-bromo-l,3-thiazol-5-yl, 2-methoxypyridin- 4-yl, 2-methy3- l,3-thiazol-5-yl, 2-methyl~2H~indazol~3-yl, 2-methyl-6- (trifluoromethyl)pyridin~3 -yl, 2-methylimidazo [ 1 ,2-a]pyridin-3 -yl, 2-methylpy ridin-3 -yl, 2- morpholinothiazol-5 -yl, 2 -phenyl- 1 ,3 -thiazol -5 -yl, 3,5 -difluoropy ridin-2-yl, 3,5 -dimethyl- 1 - (propan-2-yl)- lH-pyrazol-4-yl, 3 ,6-dimethylimidazo [2, 1 -b j [ 1 ,3 jthiazol-5 -yl, 3 -bromo- 1,2- oxazol-5-yl, 3-chloropyridin-4~yl, 3-cyclopropylisoxazol-5-yl, 3-fiuoropyridin~4-yl, 3- isopropyl- 1 -methyl- 1 H-pyrazol-5 -yl, 3 -methylpyri din-2-yl, 3 -methylpyri din-4-yl, 4 - chlor opyridin-2-yl, 4-methylpyridin-2-y 1, 5 -bromo-4-methyl- 1,3 -thiazoi-2-yi, 5 -bromo-4- methylpyridin-2-yl, 5-bromo-6-methylpyridin-2-yl, 5-bromopyridin-2-yl, 5-bromopyrimidin- 2-yl, 5-chloropyridin-2-yl, 5-chloropyridin-3-yl, 5-cyclopropylisoxazol-3-yl, 5- cyclopropylisoxazol-4-yl, 5-fiuoro-lH-indol~3-yl, 5-fiuoropyridin~3-yl, 5-methylpyridin-3-yl, 6-methoxypyridin-3 -yl, 6-methylpyridin-2-yl, 6-methyipyridin-3 -yl, benzo [d]thiazol-2-yl, imidazo[l ,2~a]pyridin~2-yl, imidazo[l,2-a]pyridin-6-yl, isoquinolin-l-yl, isoquinolin-3-yl, N,N,4-trimethylthiazol-2 -amine, N,N-dimethylthiazol-2-amine, pyridin-2-yl, pyridin-3-yl, pyridm-4-yi, quinolin-2-yi, quinolin-3-yl, quinolin-4-yl, or quinoxaim-2-yi 14. A chemical entity as in claim 1, wherein R! is chroman-2-yl, 6-fluorochroman-2-yl, chroman-3-yl, 7-methoxychroman-3-yl, 2,3-dihydrobenzofuran-2-yl, (2,3- dihydrobenzo [b] [ 1 ,4] dioxin-2-yl, or 2-methyl- 1 ,2, 3 ,4-tetrahydroisoquinolin-3-yl . 15. A chemical entity as in claim 1 , wherein R1 is phenyl substituted with two or three R" members independently selected from the group consisting of: -H, -halo, and -Ci-ehaloalkyl. 16. A chemical entity as in claim 1, wherein Z is -C=0, -R1 is 2,3-dihydro-l-benzofuran, 3,4-dihydro-2H-l-benzopyran, benzofuran, benzothiophene, naphthalene, quinoline, or phenyl, wherein phenyl is unsubstituted or substituted with two, three, or four Ra members, where R3 is a member independently selected from: -H, -CI, -Br, -F, -I, -Chalky!, -Ci-4haloalkyi, -Ci-4alkoxy, -Ci_4haloalkoxy, -OCF2H, -CN, -N(CH3)2, or -cyclopropyl. 17. A chemical entity as in claim. 1, wherein Z is -CH2, ~R! is phenyl unsubstituted or substituted with two, three or four Ra members, where Ra is a member independently selected 268 from: -I I. -CI, -Br, -F, -I, -C^alkyi, -C^haloalkyl, -Ci-4alkoxy, -CN, -Ν(€Η3}2, or -cyciopropyl. 18. A chemical entity selected from the group consisting of: (3-(5-Methy]-[ l,2,4]triazolo[l,5-a]pyrimi (2,3-Dihydro- lH-inden-5-yl)(3-(5-methy]-[l,2,4]triazolo[l ,5-a]pyrimid yl)metbanone; (^-(3-(5-Methyl-[ l ,2,4]triazolo[l ,5-a]pyrimidin-7-yl)piperidin-l-yl)(naph yl)methanone; (3-(5-Methy]-[ l,2,4]triazolo[l,5-a]pyrimidin-7-yl)piperidin-l -yl)(quino]m (2-(5-Methy]-[l,2,4]tΓiazolo[l,5-a]pyrimidin-7-yl)mo holino)(quinolin-2-yl)m (3,3-Difluoro-5-(5-methy]-[l,2,4]triazolo[ l,5-a]pyrimidin-7-yl)piperi^ methoxyph eny 1 )methanone ; (3R)-l -[(3R)-3,4-DihydiO-2H-l -benzopyran-3-carbonyl]-3-{5-m a]pyrimidin-7~yl}piperidine; l -[(2,3-Dihydro-l-benzofuraii-5-yl)carbonyl]-3-{5-me1hyl-[l,2,4]triazolo[l,5 yUpiperidine; 1 - [(3,4-Dihydro-2H-l-benzopyran-6-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5- a]pyrimidin-7~yl}piperidine; 4-[(3-Iodo henyl)carbonyl]-2-{5-methyl-[l ,2,4]triazolo[ l,5-a] yrimidin-7-yl}mo holine; 2- {5-Me1hy]-[l,2,4]triazolo[l ,5-a]pyrimidin-7-yl }-4-[(naph1halen-2-yl)carbony 3,3-Difluoro- l-[(3-iodophenyl)carbonyl]-5^ yUpiperidine; 4-[(4-Fluorophenyl)carbonyl]-2-{5-methyl-[l,2,4]triazo]o[l,5-a]pyrimidin-7-yl }mo 4-benzoy]-2-{5-rnethyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl }moφho]ine; 4-[(3-Chloro-4-fluorophenyl)carbonyl]-2-{5-methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- 4-[(3-Fluorophenyl)carbonyl]-2-{5-methyl-[l,2,4]triazo]o[l,5-a]pyrimidin-7-yl }mo 4-{ [4-Fluoro-3-(trifluoromethyl)phenyl]carbonyl}-2-{5-me1hyl-[l ,2,4]triazolo[ l,5- a] pyrimidin-7-yl } ιηοφΐι olm e ; 4-[(4-Methoxyphenyl)carbonyl]-2-{5-methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- 2- { 5 -Methyl - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } -4- [(4-phenylphenyl)carbonyl]mc^ho] ine ; 4-[(4-ChloΓo henyl)caΓbonyl]-2-{5-metilyl-[l,2,4]triazolo[l ,5-a] yrimidill-7-yl}moφholille; 4-[(3-ChloΓo henyl)caΓbonyl]-2-{5-metilyl-[l,2,4]triazolo[l ,5-a] yrimidill-7-yl}moφholille; 269 2- { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 ~a]pyrimidm-7-yl } -4- { [3 - (trifluorome†hoxy)pheiiyl]carboiiyl} iT!oq3holiiie; 4-[(3,5-Dichlorophenyl)carbonyl]-2-{5-methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl}morpholme: 4-[(2~{5-Methyl~[ l ,2,4]tnazolo[ l,5-a]py 4-| (3 ,4-Difluorophenyl)carbonyl] -2- { 5 -methyl-j 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 3 ,3 -Difluoro-5 - { 5 -methyl-[ 1 , 2,4]triazo3o [ 1 ,5 -a]pyrimidin-7-yl } - 1 - [(naphthalen-2- yl)carbonyl]piperidme; 4-j (3-Bromophenyl)carbonyl]-2-{5-met¼ 3- [(2~{5-Methyl~[ l ,2,4]tnazolo[ l,5-a]py 2- { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 ~a]pyrimidm-7-yl } -4- { [3 - (trifluoromethyl)phenyl J carbonyl } morpholine ; 2- { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a jpy rimidm-7- yl} -4- { [4- (trifluoromethyl)phenyl] carbonyl } ηιοφΐιοΐίηε ; 4- [(3-Etiloxy hellyl)caΓbollyl]-2-{5-me1hyl-[l ,2,4]triazolo[l,5-a] yrimidill-7-yl}mo holine; 4-[(3-Bromo-4-fluorophen}4)carbonylJ-2-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7- }'1}!ΐ οφ1ιοϋιιε: l-[(3-Chlorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: l-| (3,5-Dichlorophenyl)carbonyl]-3,3-difluoro-5- {5-methyl-| l,2,4 |triazolo l,5-a|pyrimidin-7- yl}piperidine; 1 - | (3 -Bromophenyl)carbonyl] -3 ,3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4 jtriazolo [1,5 -a]pyrimidin-7- yl}pipendine: 1 -| (3 -Bromo-4-fluorophenj'l)carbonyl ] -3 ,3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1,5- a]pyrimidin-7-yl}piperidine; 3- [(3,3-Difluoro-5-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7-y }piperidin-l^ yljcarbonyl J benzonitrile ; 3 ,3 -Difluoro- 1 - { [4-fluoro-3 -(tnfluoromethyl)phenyl]carbonyl} -5 - { 5 -methyl- [ 1 ,2,4 J triazolo j 1 , 5 -a] pyrimidin-7-yl } piperidine ; 3 ,3 -Difluoro-5- { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a [py rimidin-7-yl } - 1 - { [3 - (trif luoromethyDpheny 1 J carbony l } piperidine ; 1 - j (3 -Chloro-4-fluorophenyl)carbonyl J -3,3 -difluoro-5 - { 5 -methyl-j 1 ,2,4]triazolo [ 1,5- a] pyrimidin-7-y ί } piperidine ; 270 3 ,3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [4- (trifluoromethyl)phenyl] carbonyi } piperidine ; (2R)-2-{ 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]py rimidin-7-yl } -4-[(naphthalen-2- yl)earbonyi] m οφΐιοϋηε : ν1)€.3Λοηγ1]ηιοφ1ιο3ίηε: l-benzoyl-3,3-difluoro-5-{5-me1hyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidine; 1 - [(3 ,4 -Difluorophenyl)carbonyl] -3,3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]py rimidin-7- yl}piperidine; 3 ,3 -Difluoro- 1 - [(3 -fluorophenyl)carbonyl] -5 - { 5 -metbyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 3,3-Difluoro- l-[(4-fluorophenyl)carbonyl]-5-{5-melliyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: 4-| (3 , 3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]tnazoio [ 1 ,5 -a]pyrimidin-7-yl }piperidin- 1 - yl)carbonyl]benzonitrile; i-[(3~Ethoxypheiiyl)carboiiyl]-3,3~difluoro-5~{5-methy3-[l,2 yl}pipendine: 3 ,3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [3 - (trifluoromethoxy)phenyl] carbonyi } p ipe ridine ; (2 i)-4-[(3-Bromophenyl)carbonyl]-2-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- γ1}ΐΐΐοφ3ιοϋη6: (2i?)-4-[(3 -Bromo-4-fluorophenyl)carbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: (25')-4-[(3,5-Dichlorophenyl)carbonyl"|-2- {5-methyl-| 1,2,4 "|triazolo[ l,5-a|pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: (25)-4-[(3-Bromophenyl)carbonyl]-2-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: (2S)-4-[(3-Bromo-4-fluorophenyl)carbonyl]-2^ ν1}ΐΐΐοφ3ιοϋηε: (2R)-4-[(3 , 5 -Dichlorophenyl)carbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: 4-| (3 -Bromo-5 -fluorophenyl)carbonyl J -2- { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: 4-[(3 ,5 -Dibromophenyl)carbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7- yl}morpholine; l-[(3-Bromo-5-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-metiiyl-[ l,2,4]triazolo[ l ,5- a]pyrimidin-7-yl}piperidine; 1- [(3,5~Dibromophenyl)carbo¾ yl}prpendine; 3 ,3 -Difluoro-5 - { 5 -methyl-[ 1 , 2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [3 - (pentafl .uorosulfanyl )phenyl] carbonyl } piperidine ; 2- { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidm-7-yl } -4- { [3 - (pentafluorosulfanyl)phenyl]carbonyl }morpholine; 1 - [(3 -Bromo-4-methylphenyl)carbonyl] -3 ,3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5- a]pyrimidin-7-yl}piperidine; 4-| (3 -Bromo-4-methylpheny l)carbony 1 ] -2- { 5 -methyl- [ 1 ,2,4] triazolo [ i ,5 -ajpyrimidin- 7- yl}morphoiine; 4-[(4-Chloropyridm-2-yl)carbonyl]-2-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7- yl}morpholine; 4-Chloro-2-[(3 ,3 -difluoro-5 - { 5 -methyi-j 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7-yl }piperidin-l- yl)carbonyl]pyridine; 2-(4~Ch3orophenoxy)-3-[(3,3-difluoro-5-{5-methyl-[l,2,4]triazo3o[l,5-a]pyrimi yl }pipendin- i -yl)carbonyl jpy ridine ; 4- { [2-Methyi-6-(trifluoromethy l)pyridin-3 -yljcarbonyl } -2- { 5 -methyl-[ 1 ,2,4]triazolo[ 1,5- a]pyrimidiii-7-yl}morpholine; (5R)- 1 - [(3 -Bromo-4-fluorophenyl)carbony 1 ] -3 ,3 -difluoro-5 - { 5 -methyi-j 1 ,2,4 jtriazolo [1,5- a] pynmidin- 7-y 1 } piperidine ; (5S)-l-[(3-Bromo-4-fluorophenyl)carbony^ a]pyrimidin-7-yl}piperidine; (5R)- 1 -(3 -Bromo-5 -fluorobenzoyl)-3 ,3 -difluoro-5 - { 5 -methyl- j 1 ,2,4]tnazolo [ 1 ,5 -ajpynmidin- 7-yl} piperidine; (5S)~ 1 -(3 -Bromo-5 -fluorobenzoyi)-3 ,3 -difluoro-5 - { 5 -methyl- [ i ,2,4 jtriazolo j 1 ,5 -ajpyrimidm- 7-yl} piperidine; 3 -(3 , 3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]tnazolo [ 1 ,5 -a]pyrimidin-7-y 1 } piperidine - 1 -carbonyl)-2- methyl-6-(trifluoromethyl)pyridine; (25')-4-(3 ,5 -Dibromobenzoyl)-2- { 5 -methyl- j i ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7-yi}morpho3me; (5 ?)-l-(3,5-Dibromobenzoyl)-3,3-difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; (55)-l-(3,5-Dibromobenzoyl)-3,3-difluoro-5-{5-me1hyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; (5S)-l-[3,5-Bis(trifluorometiiyl)benzoyl^ a] pyrimidin- 7-y 1 } piperidine ; (5S)-l-(3,5-Dimethylbenzoyl)-3,3-difluoro^ yl}piperidine; (2^-4-(3-Bromo-5-c orobenzoyl)-2-{5-methyl-[l,2,4]triazoio[l,5-a]pyriim }71} morpholine: (25)-4-(3-Bromo-5-fluorobenzoyl)-2-{5-melliyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl} morpholine: (5,S)-l-(3,5-Dichlorobenzoyl)-3,3-difluoro-^^ yl}piperidine: (55)-l-(4-Bromobenzoyl)-3,3-difluoro-5-{5-me1hyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; (S^-l^-Bromo^^^^-telrafluorobenzoylJ-S^-difluoro-S-IS-methyl-tl^^JtriazolotljS^ a]pyrimidin-7-yl}piperidine; (55)-l-(3-Cyclopropyl-4,5-difluorobenzoyl)-3,3-difluoro-5-{5-methyl-[l ,2,4]triazolo[l,5- a] pyrimidin- 7-y 1 } piperidine ; (2i 4~[3-Metliyl-4"(propan-2-yloxy)benzoyl]-2~{5-metliyI- }Ί} morpholine: (2i 4-(4-Ethoxy-3 -metnyibenzo }Ί} morpholine: (2i 4~(3-Bromo-5-methylbenzoyl)-2-{5~metliyl-[ l,2,4]triazolo[l ,5-a]pyrimidin-7- yl} morpholine: (25)-4-(3 -Chloro-5 -methylbenzoyl)-2- { 5 -methyl- 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- }Ί} morpholine: (2i 4-[ l-Methyl-3"(propaii-2-yl)-lH-pyrazole-5"Carbonyi|-2-{5-in^ a] pyrimidin- 7-y i } morpholine ; (25')-4-[3,5-Dimethyl-4-(propan-2-}doxy)benzoyl]-2-{5-methyl-[l,2,4]triazolo[l,5- a] pyrimidin- 7-y i } morpholine ; 2-| (3 , 3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]tnazoio [ 1,5 -a]pyrimidin-7-yi }piperidin- 1 - yljcarbonyl ] q uinoline ; 273 4-[(3 -Bromo-5 -chlorophenyl)carbonyl] -2- { 5 -methyl - [ 1 ,2,4]triazo3o[ 1 ,5 -a]pyrimidin-7- yl}morpholme: 1 - [(3 -Bromo-5 -chlorophenyl)carbonyl] -3 ,3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5- a]pyrimidin-7-yl}piperidine; 3-[(2-{5-Methyl-[ l ,2,4]triazolo[l,5-a] yrimidill-7-yl}mo holin-4-yl)carbonyl]isoquinoline; 3- j (2-{5-Methyl-[ i,2,4]tnazolo[l,5-a]pynmidm 6-[(2-{5-Methyl-[ l ,2,4]triazolo[l,5-a] yrimidill-7-yl}mo holin-4-yl)carbonyl]quinoline; 6- [(2-{5-Methyl-[ l ,2,4]triazolo[l,5-a] yrimidill-7-yl}moφholin-4-yl)carbonyl]isoquinoline; 7- [(2-{5-Methyl-[ l ,2,4]triazolo[l,5-a] yrimidill-7-yl}moφholin-4-yl)carbonyl]isoquinoline; 7-j (2-{5-Methyl-[ i,2,4]tnazolo[l,5-a]pynmidm l-[(4-Cyclopropylphenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[l,2,4]triazolo[ l,5-a]pyrimidin- 7-yl}piperidine; 4_ j (4-Cyclopropylphenyi jcarbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- ν1}ΐΐΐοφ3ιο1ίηε: (2S)-4~(4-Cye3opropylbenzoyl)~2-{5-methyl~[l,2 l]triazolo[l ,5-a]pyrimidin (5»S)-l~(4-Cye3opropylbenzoyl)~3,3-difluoro-5-{5-methyl-[l,2,4]triazo3 yl}piperidine: 4- [3 -Bromo-5 -(trifluoromethyl)benzoyl] -2- { 5 -methyl-[ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7- }'1}!ΐ οφ1ιοϋιιε: 1 - | 3 -Bromo-5-(trifluoromethyl)benzoyl] -3 , 3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4] triazolo [1,5- a] pyrimidin- 7-y i } piperidine ; (5>5)~l~[3-Brom.o~4~(trifl.uoromethy. a] pyrimidin- 7-y i } piperidine ; (S^-l^S-Bromo-S-fluoro^-memylbenzoy -S -difluoro-S- S-methjd-t l^^JtriazoloI ljS- a] pyrimidin- 7-y i } piperidine ; (5,S)-3 ,3 -Difluoro- 1 -(4-fluoro-3 ,5 -dimethylbenzoyl)-5 - { 5 -methyl-[ 1 , 2,4]triazolo [ 1,5- a] pyrimidin- 7-y i } piperidine ; (5S)-1 -(3 -Chloro-5 -fluoro-4-methoxybenzoy l)-3 ,3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1,5- a] pyrimidin-7-y i } piperidine ; a] pyrimidin-7-y i } piperidine ; (5S)-1 -(3 ,5 -Dibromo-4-methylbenzoyl)-3 ,3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4 jtriazoio [1,5- a] pyrimidin-7-y i } piperidine ; 274 (5,S)-3 ,3 -Difluoro-5 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7-yi } - 1 -(3 ,4,5 - trifluorobenzoyl)piperidine; (5,S)-3 ,3 -Difluoro-5 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7-yl } - 1 -(3 ,4,5 - trichlorobenzoyl)piperidine; (55)-l-(3,5-Dichloro-4-fluorobenzoyl)-3,3-difluoro-5-{5-metiiyl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl}piperidine; (55)-l-(3-Chloro-4,5-difluorobenzoyl)-3,3-difluoro-5-{5-metiiyl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl}piperidine; (55)-l-(3-Bromo-4,5-difluorobenzoyl)-3,3-difluoro-5-{5-methyl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl } piperidine; (2>5)~4~(3-Cyx3opropylbenzoyl)~2-{5-methy (5>5)~l~(3-Cyx3opropylbenzoy3)~3,3~difi yl}pipendine: (25')-4-(3-Cyclopropyl-4-fluorobenzoyl)-2-{5-methyl-[ l,2,4]triazolo[l,5-aJpyrimidin-7- yl}morpholine; (55)-l-(3-Cyclopropyl-4-fluorobenzoyl)-3,3-difluoro-5-{5-metliyl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl } piperidine; (25')-4-(3-Cyclopropyl-4,5-difluorobenzoyl)-2-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}morpholine; (55')-l-(4-Cycloprop}7l-3-fluorobenzoyl)-3,3-difluoro-5-{5-methyl-[l,2,4]triazolo[ l,5- a]pyrimidin-7-yl } piperidine; (55)- 1 -(4-Cy clopropyl-2,3 -difluorobenzoyi)- 3 ,3 -difluoro-5 - { 5-methyl- [ 1 ,2,4]triazolo [1,5- a] pyrimidin- 7-y 1 } piperidine ; (25')-4-(4-Cyclopropyl-3-fluorobenzoyl)-2-{5-methyl-[ l,2,4]triazolo[l,5-aJpyrimidin-7- }7l}morpholine; (2i?)-4-(4-Cyclopropyl-3 -fluorobenzoyl)-2- { 5 -methyl- [ 1 ,2,4]triazo3o [ 1 ,5 -a]pyrimidin-7- }7l}morpholine; (25')-4-(4-Cyclopropyl-2,3-difluorobenzoyl)-2-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- }7l}morpholine; (2 i)-4-(4-Cyclopropyl-2,3-difluorobenzoyl)-2-{5-methyl-[l,2,4]triazolo[ l,5-a]pyrim ^ yl}morpholine: (55)- 1 -(4-Bromo-3 -chlorobenzoy l)-3 ,3 -difluoro-5 - { 5 -methyl- [ ,2,4]triazolo [ 1 ,5 -ajpyrimidin 7-yl} piperidine; 275 (2i?)-4-(4~Bromo~3 -chlorobenzoyl)-2- { 5 -methyl - [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- o-3-c orobenzoyl)-2-{5-me^ (2<S)-4-(3 -Chloro-4-cyclopropylbenzoyl)-2- { 5 -methyl - [ 1 ,2,4]triazo3o [ 1 ,5 -a]pyrimidin-7- }7l}morpholine: (55)-l-(3-Chloro-4-cyclopropylbenzoyl)-3,3-difluoro-5-{5-methyl-[l ,2,4]triazolo[l,5- a]pyrimidin-7-yl}piperidine; (25)-4-(3-Fluoro-5-metiiylbenzoyl)-2-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7- }7l}morpholine: (25)-4-(4-Fluoro-3-metiiylbenzoyl)-2-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7- (3 i)- l-[(35)-3,4-Dihydro-2H-l-benzopyran-3-carbonyl]-3-{5-methyl-[ l,2,4]triazolo[l,5- a]pyrimidin-7-yl }piperidine; (35)-l-[(3^-3,4-Dihycko-2H-l-benzopyraii-3-carbonyl]-3-{5-met yl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl}piperidine; a] pyrimidin- 7-y 1 } piperidine ; (2i?)-4-[3 -Bromo-4-(trifluoromethyl)benzoyl] -2- { 5 -methyl-[ 1 , 2,4]triazolo [ 1 ,5-a]pyrimidin- }7l}morpholine: (3R)-3- { 5 -Methyl-[ 1 ,2,4 ]triazolo[ 1 ,5 -a ]pyrimidin-7-yl } - 1 - [(naphthalen-2- yl)carbonyl]piperidine; 1 - j (4-Chioro-3 -iodophenyl)carbonyl] -3 ,3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4 jtriazolo [1,5- a] pyrimidin- 7-y 1 } piperidine ; 3 ,3 -Difluoro- i - [(4-fluoro-3 -iodophenyl)carbonyl] -5 - { 5 -methyl- [ 1 ,2,4]triazoio [1,5- a]pyrimidm-7-yl}piperidine; (5,S)~1 -( 1 -Benzofuran-5 -carbonyl)-3 ,3 -difluoro-5 - { 5 -methyl- [ 1 ,2,4]triazolo 1 ,5 -ajpyrimidin 7-yl} piperidine; (5i 3,3-Difluoro-l-(4-methoxy-3-m^ a]pyrimidin-7-yi } piperidine; (25')-4-(4-Methoxy-3-methylbenzoyl)-2-{5-methyl-[ l,2,4]triazolo[l,5-aJpyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε; 1 -(6-Fluoro-3 ,4-dihydro-2H- 1 -benzopyran-3 -carbonyl)-3 - { 5 -methyl- 1 ,2,4]tnazolo [ 1,5- a] pyrimidin- 7-y i } piperidine ; 276 4-[l-(4-Fluorophenyl)-5-methyl-lH-pyrazole-3-carbonyl]-2-{5-methyl-[l,2,4]triazolo[l ,5- a]pyrimidm-7-yl}morpholine; l-{5-Methyl-l-[4-(propan-2-yl)phenyl]-lH-pyrazole-3-carbonyl}-3-{5-methyl- [ 1 ,2 ,4]triazolo [ 1 , 5 -a] pyrimidin-7-yl } piperidine ; 4-{5-Methyl-l-[4-(propan-2-yl)phenyl]-lH-pyrazole-3-carbonyl}-2-{5-methyl- [ 1 ,2,4Jtriazolo[ 1 ,5-a]pj imidm-7-yl}moipholine; l-[(6~Fluoronaphthalen-2~yl)carbonyl]-3~{5-methy3-[l,2,^ yl}piperidine; 6- [(3~{5-Methyl~[l ,2,4]tnazolo[i,5-a]py 1 - [(2,2-Difluoro-2H- 1 ,3 -benzodioxol-5 -yl)carbonyl] -3 - { 5 -metbyl-[ 1 ,2,4]tnazolo [ 1,5- a]pyrimidin-7-yl}piperidine; l-[(2,3-Dihycko-l-benzofuran-2-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyri^ yl}piperidine; 1 - |"(3 ,4-Dihydr 0-2H- 1 -benzopy ran- 3 -yi)carbonyi j - 3 - { 5 -methyl-[ 1 ,2,4 [iriazolo 11 , 5 - a]pyrimidin-7-yl}piperidine; l-[(3,4-Dihy(ko-2H-l-benzopyran-2-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5- a] pyrimidin-7-y 1 } piperidine ; 7- yl}piperidine; 1 - j (6-Fi uoro-3 ,4-dihy dro-2H- 1 -benzopyran-2-yl)carbonyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [ 1,5- a]pyrimidin-7-yi } piperidine; 2- Methyi-3-[(3~{5-methyl-[l,2,4]ta^ 1,2,3,4-tetrahydroisoquinoline; 1 -j (3 -lodophenyl)carbonyl ] -3 - { 5 -methyl-[ 1 ,2,4]tnazoio [ 1 ,5 -a]pyrimidin-7-yl}piperidine; 1 -| (4-lodophenyl)carbonyl ] -3 - { 5 -methyl-[ 1 ,2,4]tnazoio [ 1 ,5 -a]pyrimidin-7-yl}piperidine; 4-[(3 ,4 -Dihydro-2H- 1 -benzopyran-3 -yl)carbonyl] - 2- { 5 -methyl -[ 1 ,2,4]triazo3o [ 1,5- a] pyrimidin-7-y i } morpholine ; 4-[(2,3-Dihy(ko-l-benzofuran-5-yl)carbonyl]-2-{5-methyl-[l,2,4Jtriazolo| l,5-ajpyrimidin-7- ν1}ιηοφ3ιοϋηε; 4-| (3 , 5 -Difluoropyridin-2-yl)carbonyl] -2- { 5 -methyl-[ 1 ,2,4 [triazolo [ 1 ,5 -a |pyrimidm-7- ν1}ιηοφ3ιοϋηε; 1 -| (2, 3 -Dihydro- 1 -benzofuran-5 -y l)carbonyi [ -3 ,3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4]tnazolo [ 1,5- a] pyrimidin-7-y i } piperidine ; 277 1 - [(3 ,4 -Dihydro-2H- 1 -benzopyran-3 -yl)carbonyl] -3,3 -difluoro-5 - { 5 -methyl- [ 1 ,2 ,4]triazolo [ 1 , 5 -a] pyrimidin-7-yl } piperidine ; 4-(3,4-Dichlorobenzoyl)-2-{5-methyl-[ l,2,4]1τiazolo[l,5-a] yrimidin-7-yl}mo holine; 3 ,3 -Difluoro- 1 -(7-methoxy-3,4-dihydro-2H- 1 -benzopyran-3 -carbonyl)-5 - { 5 -methyl- [l,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidine; l-[(3R)-3,4-Dihydro-2H-l-benzopyran-3-carbonyl]-3-{ 5-methyl-[l,2,4Jtriazolo[l,5- a]pyrimidin-7-yl}piperidine; l-[(3S)-3,4-Dihycko-2H- l-benzopyran-3-carbonyl]-3-{5-metliyl-[l ,2,4]triazolo[l,5- a]pyrimidin-7-yl}piperidine; (25')-4-[3-Bromo-4-(trifluoromethyl)benzoyl]-2-{5-methyl-[ l,2,4]triazolo[ l,5-aJpyrimM yl}morpholme: (25)-4-(3-Bromo-4,5-difluorobenzoyl)-2-{5-me1hyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- (2S)-2~{ 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } -4-(3 ,4, 5 -trichlorobenzoyl)mc^holine ; (2»S)-4~(3 ,5 -Dichloro-4-fluorobenzoyl)-2- { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- } 1}!Ήθφ1ιοϋηε: (25')-4-(l-Benzofuran-5-carbonyl)-2-{5-methyl-[ l,2,4]triazolo[ l,5-aJpyrimidin-7- (2,5)~4-(2,2-Difiuoro-2H- 1 ,3 -benzodioxole-5 -carbonyl)-2- { 5 -methyl-[l,2,4]triazolo[l,5- a] pyrimidin-7-y 1 } morpholine ; (2,S 4-( 1 -Methyl-3 -phenyl- lH-pyrazole-5 -carbonyl)-2- { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1,5- a] pyrimidin-7-y 1 } morpholine ; (25')-4-[(3 i)-3,4-Dihydro-2H-l-benzopyran-3-carbonyl]-2-{5-methyl-[ l,2,4]triazolo[l,5- a] pyrimidin-7-y 1 } morpholine ; (2S)-4-[(3S)-3,4-Dihyclro-2H-l-benzo a]pynmidiii-7-yl}morpholine; l-[(25)-2,3-Dmydro-l,4-benzodioxine-2-carbonyl]-3-{5-methyl-| 1,2,4 jtriazolo [ 1, - a]pyrimidin-7-yi } piperidine; 1 -(2, 3 -Dihydro- 1 -benzofuran-6-carbonyl)-3 - { -methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidm-7- yl}pipendine; 1 - j (2i?)-2,3 -Dihydro- i ,4-benzodioxine-2-carbonylJ -3 - { 5 -methyl- [ 1 ,2,4]tnazoio [1,5- a]pyrimidin-7-yi } piperidine; 4- j 1 -(2 -Fluorophenyl)- lH-pyrazole-3 -carbonyi j -2- { 5 -methyi- [ 1 ,2,4] triazolo [1,5 -ajpyrimidin- 7-yl} morpholine; 278 4-[l~(2-Chlorophenyl)~lH~pyraz 7-yl } morpholine ; 4-[ 1 ~{3 -Bromophenyl)- ΙΗ-py razole-3 -carbonyl] -2- { 5 -methyl -[ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin 7-yl } morpholine ; 4-[ 1 -(4-Chlorophenyl)-5 -methyl- lH-pyrazole-3 -carbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo [1,5- a] pyrimidin-7-y 1 } morpholine ; 4-[ 1 ~{3 -Fluorophenyl)- lH-pyrazole-3 -carbonyl] -2- { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin 7-yl } morpholine ; 4-Methyl-2-[(3~ {5-methyl -[ 1 ,2,4]triazo3o[ 1 ,5-a]pyrimidin-7-yl }piperidin- 1 - yl)carbonyl ] pyridine ; 2- Me1hoxy-5-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)carbonyl]pyridine; 3 - | (3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1,5 -a]pyrimidin-7-yl }piperidin- 1 -yljcarbonyl] pyridine: 2- [(3-{5-Meth}d-[ l,2,4]triazolo[l,5-a]pyrimidm-7-yl}piperidin-l-yl)carbonyl]-l,6^ naphthyridine; 3- [(3-{5-Methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7-y^ 3 -Methy l-4-[(3 - { 5-methyl-[ 1 ,2,4]triazoio [ 1 ,5 -ajpy rimidm-7-yl }piperidin- 1 - yl)carbonyl]pyridine; 2- Methyl-6-[{3- {5-methyl -[ 1 ,2,4]triazo3o[ 1 ,5-a]pyrimidin-7-yl }piperidin- 1 - yl)carbonyl] pyridine ; 4- [(3-{5-Meth}d-[ l,2,4]triazolo[l,5-a]pyrimidm-7-yl}piperidin-l-yl)carbonyl]pyrid^ 3- Me1hyl-5-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)carbonyl ] pyridine ; 1 -( { Imidazo [ 1 ,2-a]pyridin-6-y 1 } carbonyl)-3 - { 5 -methyl- [ 1 ,2,4]triazo3o [ 1 , 5-ajpy "rimidin-7- yl}prpendine: 2-[(3~{5-Methyl~[l ,2,4]tnazolo[l,5-a]pynmidin-7-yl}piperidin-l~y3^ 7-| (3-{5-Methyl-[ l,2,4]triazolo[L5-a]pyrimidin-7-yl}piperidin-l-yr}carbony 7-| (3-{5-Methyl-[ l,2,4]triazolo[L5-a]pyrimidin-7-yl}piperidin-l-yr}carbony 3 -Methy l-2-[(3 - { 5-methyl-[ 1 ,2,4]triazoio [ 1 ,5 -ajpy rimidm-7-yl }piperidin- 1 - yl)carbonyl] pyridine ; 1 -j (3 - { 5 -Methyl-[ 1 ,2,4]triazolo[ 1,5 -a]pyrimidin-7-y 1 }piperidin- 1 -yl)carbonyl]isoquinoline; 2 -Methy 1-3 -[(3 - { 5-methyl-[ 1 ,2,4]triazolo [ 1 ,5 -ajpy rimidm-7-yl }piperidin- 1 - yl)carbonyl ] pyridine ; 279 3 -Chloro-5 ~[(3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7-yl jpiperidin- 1 - yl)carbonyl]pyridine; 2- Me1hoxy-4-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l - yl)carbonyl]pyridine; 3- Fluoro-5-[(3-{5-metiiyl-[ l,2,4]triazolo[ l ,5-a]p Timidiii-7-yl}piperidin-l- yljcarbonyl J pyridine ; 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 -( {2-methylimidazo [ 1 ,2-a]pyridin-3 - yl } carbony l)p ipe ridine ; 3 -Chioro-4~[(3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7-yl jpiperidin- 1 - yljcarbonyl J pyridine ; 2-[(3-{5-Methyl-[ l ,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l-yl)carbonyl]quinoline; 6-[(3~{5-Methyl~[ l ,2,4]tnazolo[ l,5-a]py 1 -( { Imidazo [ 1 ,2-a]pyridin-2-y 1 } carbonyi)-3 - { 5 -methyl- [ 1 ,2,4 jtriazolo [ 1 , 5-a]pyrimidin-7- yl}prpendine: l-[( l-Methyl-lH-pyrrol-2-yl)carbonyl]-3-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine; 1 - 1 "(2-Methoxy- 5 -methylpheny l)carbony Γ| - 3 - { 5 -methyl- [ 1 ,2,4 jtriazolo j 1 , 5 -a jpyrimidin-7- yl}piperidine; 1- [( 1 ,3 -Dimethyl- 1 H-pyrazol-5 -yl)carbonyl]-3 - { 5 -methyl-[ 1 ,2,4]triazoio [1,5 -a]py rimidin-7- yl}prpendine: 1 - [(2-Fluor 0-3 -methy lphenyl)carbonyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a j py rimidm-7-yl } - 1 - [(naphthalen- 1 -yl)cat¾onyi]piperidine ; 1 - [(3 -Chlorophenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl} piperidine; 1 - [(2-Fluoro-4-methoxyphenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 1 - j (2-Methoxy-4-methylphenyi)carbonyi j -3 - { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1,5 -a jpyrimidin-7- yl}pipendine: 1 - [(3 -Fluor 0-5 -methoxyphenyDcarbonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo j 1 ,5-a]pyrimidin-7- yl}prpendine: 1 - j (2-Fiuoro-4-methy lphenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}pipendine: 2- [(3-{5-Methyl-[ l,2,4]triazolo[ l,5-a]pyrimidm-7-y^ 280 i-Methyl-3-[{3~{5-methyi-[l,^ indole; 6-[(3-{5-Methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l-yl)carbonyl]-l,3- benzothiazole; l-[(3-Methoxy-2-methylphenyl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyTimidin-7- yl}pipendine: l-[(l~Benzofijran-5-yl)carbonyi]-3-{5-methyi-[l,2,4]triazolo[l,5-a]p 3-{5-Methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l -[(5,6,7,8-tetr^ydronaphthalen-2- yl)carbonyl]piperidine; l-j (3-Cyclopropyl-l,2-oxazol-5-yl)carbonyi^ yl}piperidine; l-[(2-Chlorophenyl)carbonyl]-3-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7-yl}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yl } - 1 - [(2-pheny lphenyl)carbonyl]piperidine; 1 - j (2, 3 -Difluorophenyl)carbonyl] -3 - { 5 -methyl- [ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7- yl}piperidine; l-[(5-Cyclopropyl-l,2-oxazol-4-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: l-[(l-Me l-5-phenyl-lH-pyrazol-3-yl)carbonyl]-3-{5-methyl-[L2,4]triazolo[l,5- a]pyrimidin-7-yl}piperidine; l-[(l,5-Dimethyl-lH-pyrazol-4-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-aJpyrim yl}pipendine: 1 - [( 1 ,5 -Dimethyl- 1 H-pyrazol-3 -yl)carbonyl] -3 - { 5-methyl- [ i ,2,4]triazolo[ 1 ,5 -a]py rimidin-7- yl}pipendine: 1 - 1 (2, 5 -DifluorophenyDcar bonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo [1,5 -a] py rimidin-7- yl}pipendine: l-[(5-Cyclopropyl-l,2-oxazol-3-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7-yl } - 1 - { j 1 -(propan-2-yl)- lH-pyrazol-4- yl ] carbonyl } piperidine ; l-[(2,4-Dichlorophenyl)carbon}4]-3-{5-meth}4-[ l,2,4]triazolo[l,5-a]p\ imidin-7- yl}pipendine: 1 - { [ 1 -Methyl-3 -(propan-2-yl)- lH-pyrazol-5 -yljcarbony 1 } -3 - { 5 -methyl- [ 1 ,2,4] triazolo [1,5- a] pyrimidin- 7-y i } piperidine ; 281 l-[(2,5-Dichlorophenyl)carbonyl]-3-{5-methyl-[ l ,2,4]triazolo[ l,5-a]pyrimidin-7- yl}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl }-! -[( ! -phenyl- 1 H-pyrazol-4- yl)carbonyl]piperidine; 1 - [(4-Chloro-2-fluorophenyl)carbonyl] ~3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7- yl}pipendine: l-[(5~Fluoro-2~methylpheny3)carbony3]-3~{5-fflethyl-[ l,2 l]triazolo[l ,5 yl}piperidine; l-[(3 ,4 -Dimethoxyphenyi)carbonyl] -3 -{5 -methyl -[ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - [( 1 -Ethyl - 1 H-pyrazol -5 -yl)carbonyl] -3 - { 5 -methyl - [ 1 ,2,4]triazolo [ 1,5 -a] pyrimidin-7 - yl}piperidine; l-[(4-C¾lorophenyl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-}4}piperidine; l-[( l-Methyl-3-phenyl-lH-pyrazol-5-yl)carbonyl]-3-{ 5-methyl-[ l,2,4Jtriazolo[ l,5- a]pyrimidin-7-yl}piperidine; 1 - [( 1 -Methoxynaphthalen-2-yl)carbonyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]py rimidin-7- yl}pipendine: 1 - [(6-Methoxynaphthalen-2-yl)carbonyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]py rimidin-7- yl}piperidine; l-[(2H- l,3-Benzodioxol-5-yl)carbonyl]-3-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: 1 - [(3 -Methoxynaphthalen-2-yl)carbonyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]py rimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ 1 ,2,4 jtriazo!o [ 1 ,5 -a jpy rimidin-7-yl } - 1 - { j 3 -(propan-2- yl)phenyl | carbonyl } piperidine ; 1 - [(2,3 -Dimethoxyphenyl)carbonyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo [ 1 ,5 ~a]pyrimidin~7- yl}pipendine: 1 - [( 1 -Benzothiophen-5 -yl)carbonyl | -3 - { 5 -methyl-[ 1 ,2,4 Jtriazolo [1,5 -a|pyrimidin-7- yl}pipendine: 1 -[(2, 3 -Dihydf o- 1 ,4-benzodioxin-6-yl)carbonyl"| - 3 - { 5 -methyl-[ 1 ,2,4 [triazolo [ 1 , 5-a jpyrimidin- 7-yl} piperidine; 1 - | (2,4-Dimethy lphenyl)carbonyl] -3 - { 5 -methyi-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}pipendine; 1 - j (2-Methoxyphenyi)carbonyi] -3 - { 5 -metliyl-[ 1 ,2,4]tnazolo [ 1 ,5 -a]pyrimidin-7-y 1 } piperidine ; 282 1 -[(2-Fluoro-5 -methoxyphenyl)carbonyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine; 1- [( l-Benzothiophen-2-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 3 - { 5 -Methyl-[ ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [4-(propan-2- yljphenyl j carbonyl } piperidine ; 2- [(3-{5-Methyl-[ l ,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l-yl)carbonyl]-l,3- benzothiazole; 1 -[(5 -Fluoro-2-methoxyphenyl)carbonyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo[l ,5-a]pyrimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - [(3 -phenylphenyl)carbonyl]piperidine; l-Me1hyl-3-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]py indazole; 1 -j ( 1 -Benzofiiran-2-y l)carbonyl ] -3 - { 5-methyl- [ 1,2,4 j triazolo 1 1 , 5 -a]pyrimidin-7-yl}piperidine; l-[(3-Methoxyphenyl)carbonyl]-3-{5-metiiyH l-Me1hyl-2-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l-yl)carb indole; l-[(2,5-Dimethylphenyl)carbonyl]-3-{5-metiiyl-[l,2,4]triazolo[ l ,5-a]pyriniidin-7- yl}piperidine; 1 - j (4-Fi uor o-2-methoxyphenyl)car bonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo [ 1 ,5-a]pyrimidin-7- yl}pipendine: 1 -[(3 -Fluoro-2-methoxyphenyl)carbonyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo[l ,5-a]pyrimidin-7- yl}pipendine: 1 - [(3 -Fluor o-2-methy lphenyl)carbonyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}pipendine: l-[( l-Benzothiophen-3-yl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: 1 - j (3 -Chloro-5 -fluorophenyl)carbonyl] -3 - { 5 -methyi-[ 1 ,2,4]triazolo [ l,5-ajpyrimidin-7- yl}pipendine: 1 - j (2,6-Difluorophenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - [(Dime thyl- 1 ,3 -thiazoi-5 -vDcarbonyl] -3 - { 5 -methyl- [ 1 ,2,4 jtriazolo j 1 ,5 -a]pyrimidin-7- yl}pipendine: 283 1 - [(5 -Chloro-2-fluorophenyl)carbonyl] ~3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7- yl}piperidine; 1- [(4-Fluoro-3-methylphenyl)carbony yl}piperidine; 2- [(3-{5-Methyl-[ l ,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l-yl)carbonyl]benzonitrile; 2.-Methyl-3 -[(3 - { 5-methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7-yl }piperidin- 1 -y l)carbony 1 ] -2H- indazole; 2-Me1hyl-5-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)carbonyl]pyridine; 1 -Benzoyl-3 - { 5 -methyl-[ 1 ,2,4 ]triazolo[ 1 ,5 -a ]pyrimidin-7-yl }piperidine : 1 - [(4-Chloro-3 -fluorophenyl)carbonyl] ~3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7- yl}piperidine; 1 - 1 "(4-Methoxy- 3 -methylpheny l)carbonyi| - 3 -{ 5 -methyl- [ 1 ,2,4 jtriazolo j l,5-ajpyfimidin-7- yl}pipendine: 1 - [(2-Chloro-5 -fluorophenyl)carbonyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7- yl}piperidine; 1 -| (3 -Chloro-2-fluorophenyl)carbonyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; l-[(4-Fluoro-2-methylphenyl)carbonyl]-3-{5-me1hyl-[l,2,4]triazolo[l ,5-a]p^ yl}pipendine: 1 - [(2,4-Difluorophenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo j 1 ,5 -a]pyrimidin-7- yl}piperidine; 1 - j (3 ,4-Difluorophenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazolo j 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - j (2, 3 -Dimethy lphenyl)carbonyl] -3 - { 5 -methyl- j 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 1 - j (2-Chloro-3 -methylphenyl)carbony 1 j -3 - { 5 -methy l-[ 1 ,2,4]triazolo [ 1 ,5 -aJpyrimidin-7- yl}pipendine: 1 - { j 4-(DifluoiOmethyl)phenyi jcarbonyl} -3 - { 5-methyl- j 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7- yl}pipendine: 4-j (3-{5-Methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l-y3)carbony 1 - j (4-Methoxy-2-methylphenyl)carbonyi j -3 - { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1,5 -a jpyrimidin-7- yl}pipendine: 284 l-[(2-Fluoro-5-methylphenyl)carbonyl]^^ yl}piperidine; 3-{5-Methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l -[(4-phenylphenyl)carbonyl]piperidine; l-[(2,6-Dimethylphenyl)carbonyl]-3-{5-metliyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine; 1 - | X2-Chloro-6-fluorophenyl)carbonyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1,5 -a]pyrimidin-7- yl}piperidine; 1- [(2-Fluoro-6-methox>^henyl)carbonyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]py yl}piperidine; 1 - [(2-Chloro-6-methylphenyl)carbony 1] -3 - { 5 -methy l-[ 1 ,2,4]triazoio [ 1 ,5 -aJpyrimidin-7- yl}piperidine; 2- (3,3-Difluoro-5-{5-methy -[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidm methyl- lH-indole; l-(l-Benzofuraii-5-carbonyl)-3,3-difluoro-5-{5-methyl"[l,2,4]tiiazoio[l^ yl}piperidine; 3,3-Difluoro-l-(4-methoxy-2-metiiylbenzoyl)-5-{5-memyl-[l,2,4]triazolo[l ,5-a]pyrimidm-7- yl}pipendine: 3,3-Difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l-(5,6,7,8- tetrahydronaphthalene-2-carbonyl)piperidine; 3 -(3 , 3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-y 1 } piperidine - 1 -carbonyl)- 1 - methyl- lH-indole; 1 -( 1 -Benzothiophene-5 -carbonyl)-3 ,3 -difluoro-5 - { 5 -methyl -[ 1 ,2,4]triazolo[l ,5-a]pyrimidin- yl}pipendine: l-(3-Chloro-5-fluorobenzoy )-3,3-difluoro-5-{5-meth}4-[l,2,4]triazolo[ l,5-a]pyTimidin-7- yl}piperidine; 3,3-Difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l -(4- phenylbenzoyl)piperidine; 3 ,3 -Difluoro- 1 -(2-methoxy-4-methylbenzoyl)-5 - { 5 -methyl- j 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7- yl}pipendine: 3,3-Difluoro-l-{imidazo[l,2-a]pyridine-6-carbonyl}-5-{5-methyl-[l,2,4]triazol^ a] pyrimidin- 7-y 1 } piperidine ; 2 -(3 , 3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4]tnazolo [ 1 ,5 -a]pyrimidin-7-y 1 } piperidine - 1 - carbony l)quinoxaline ; 285 3,3-Difluoro- l-{imidazo[l,2-a]pyridine-2-carbonyl}-5-{5-methyl-[l,2,4]triazolo[l ,5- a]pyrimidin-7-yl}piperidine; l-(l-Benzothiophene-3-carbonyl)-3,3-difluoro-5-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidm- yl}piperidine; 3,3-Difluoro- l-(2-methoxy-5-metiiylbenzoyl)-5-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidiii-7 yl}piperidine: 1 - [4-(Difluoromethyl)benzoyl] -3 ,3 -difluoro-5 - { 5-methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- yl}piperidine; 1 -(3 ,4-Dimethoxybenzoyl)-3 ,3 -difluoro-5 - {5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine: l-(5-Chloro-2-fluorobenzoyl)-3,3-difluoro-5-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimid yl}piperidine; 3,3-Difluoro-l-(4-fluoro-3-methylbenzoyl)-5-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine: 3,3-Difluoro- l-(4-methoxy-3-metiiylbenzoyl)-5-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidiii-7 yl}piperidine; 3 ,3 -Difluoro- 1 -(3 -methoxybenzoy l)-5 - { 5 -methy l-[ 1 ,2,4] triazolo [ 1 ,5 -ajpyr imidin-7- yl}piperidine; l-(2H- l,3-Benzodioxole-5-carbonyl)-3,3-difluoro-5-{5-metliyl-[l ,2,4]triazolo[l,5- a] pyrimidin- 7-y 1 } piperidine ; 1 -(2, 3 -Dihydro- 1 ,4-benzodioxine-6-carbonyl)-3 ,3 -difluoro-5 -{ 5-methyl- 1 1 ,2,4]triazolo [ 1 ,5- a]pyrimidin-7-yl}piperidine; 3 ,3 -Difluoro- 1 -(3 -methoxynaphthaiene-2-carbonyl)-5 - { 5 -methyl- [ 1 ,2,4]tnazolo [ 1,5- a] pyrimidin- 7-y 1 } piperidine ; 3 ,3 -Difluoro-5 - { 5 -methyl-j 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yl} - i - [4-(propan-2- yl)benzoyl]piperidine: 3,3-Difluoro-l-(2-fluoro-5-methylbenzoyl)-5-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine: 3 ,3 -Difluoro- 1 -(3 -fluoro-5 -methoxybenzoyl)-5 - { 5-methyl-[ 1 ,2,4 jtriazolo [ 1 ,5-a jpy rimidin-7- yl}piperidine: 1 -(2, 3 -Dihydro- lH-indene-5 -carbonyl)-3 ,3 -difluoro-5 - { 5 -methyl- [ i ,2,4 jtriazolo [1,5- a] pyrimidin- 7-y 1 } piperidine ; 3 ,3 -Difluoro- i -( 1 -methoxynaphthalene-2-carbonyl)-5 - { 5 -methyl- [ i ,2,4]tnazolo [ 1,5- a] pyrimidin- 7-y 1 } piperidine ; 286 3 ,3 -Difiuoro- 1 -(6-methoxynaphthalene-2-cai onyl)-5 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5- a]pyrimidin-7-yl}piperidine; 3 ,3 -Difiuoro- 1 -( 1 -methyl -3 -phenyl- 1 H-pyrazole-5 -carbonyl)-5 - { 5 -methyl-[ 1 ,2,4]triazolo[ 1,5- a]pyrimidin-7-yl}piperidine; 3 ,3 -Difiuoro- 1 -(6-fluoroiiaphthalene-2-carbonyl)-5 - { 5 -methyl- [ 1 ,2,4]triazolo[ 1,5- a] pyrimidin-7-y 1 } piperidine ; 2-(3,3-Difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidm benzothiazole; 1 -(2, 2-Difluoro-2H- 1 ,3-benzodioxole-5 -carbonyl)-3, 3 -difluoro-5 - { 5 -methyl - [ 1 ,2,4] triazolo [ 1 , 5 -a] pyr imidin-7-yl } piperidine ; 3,3-Difluoro-5-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l-[3-(propan-2- yl)benzoyl]piperidine: 3 ,3 -Difluoro-5 - { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yl }-!-(! -phenyl- lH-pyrazole-4- carbonyi)piperidine ; 1- Me1hyl-2-(2-{5-methyl-[l,2,4]triazolo[l,5-a]pyriim indole; 4-( 1 -Benzof uran-5-carbonyl)-2- { 5 -methyl- [ 1 ,2,4 jtriazolo j 1 ,5 -a]pyrimidm-7-yl }morpholine : 4-(l-Benzothiophene-5-carbonyl)-2-{5-me1hyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yljmoqjholine: 4-(2-Methoxy-4-methyibenzoy3)-2- { 5 -methyl- j 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7- yljmoqjholine: 4-{lmidazo[ l,2-a]pyridine-6-carbon}4} -2-{5-methyl-[l,2,4]triazolo[l,5-aJpyrim ν1}ΐΐΐοφ3ιοϋηε: 4-( 1 -Benzof uran-2-carbonyl)-2- { 5 -methyl- [ 1 ,2,4 |triazoio 1 ,5 -a]pyrimidin-7-yl }ΐΐΐοφ3ιοϋηε : 2- (2~{5-Mεtllyl~[l,2, ]triazoϊo[l,5-a]pyrinlidin-7-yl}mo hoϊine~4-carbony 4-( 1 -Benzothiophene-3-carbonyl)-2- { 5 -methyl-[ 1 ,2,4]tnazoio [ 1 ,5 -aJpyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: 4-(2-Methoxy-5 -methyibenzoyi)-2- { 5 -methyi-j 1 ,2,4 jtriazolo j 1 ,5 -a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: 4-[4-(Difluoromethyl)benzoyl]-2-{5-methyl-| 1,2,4 jtriazo3o[l,5-ajpyrimidίn-7-yi}moφho3ine: 4-(3 ,4-Dimethoxybenzoyi)-2- { 5 -methyl- j 1 ,2,4]tnazolo [ 1 ,5 -a]pyrimidin-7-y 1 } morpholine ; 4-(4-Fluoro-3-meώylbenzoyl)-2-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7-yl}mo holine^ 287 4-(4-Methoxy-3-metiiylbenzoyl)-2-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- γΐΐηιοφΐιοϋηε: 4-(3 -Methoxybenzoyl)-2- {5 -methyl- [ 1 ,2,4]triazoio [1,5 -a]py rimidin-7-yl }ηιοφ1ιοί ine ; 4-(2H-l,3-Benzodioxole-5-carbonyl)-2-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 4-(2-Methoxyp}7ridine-4-carbonyl)-2-{5-methyl-| 1,2,4 ]triazolo[l,5-a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 4-(2, 3 -Dihydro- 1 ,4-benzodioxine-6-carbonyl)-2- { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 4-(3 -Methoxynaphihalene-2-carbonyl)-2- { 5-methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 2- { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } -4-[4 -(pro an-2-yl)benzoyl]mo holine ; 4-(2-Fluoro-5-methylbenzoyl)-2-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7-yl}mo holine; 4-(3 -Fluoro-5 -methoxybenzoyl)-2- { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 4-(l-Methoxynaphthalene-2-carbonyl)-2-{5-melliyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- γ1}ΐΐΐοφ1ιοΙίηε: 4-(6-Methoxynaphihalene-2-carbonyl)-2- { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- } 1}!·ηοφ1ιοϋηε: 4-( 1 -Methyl-3 -phenyl- IH-pyr azole-5 -carbonyl)-2- {5 -methyl- 1 ,2,4]triazolo [ 1 ,5 -ajpynmidin- 7-yl}mcwpholine; 4-(6-Fluoronaphthalene-2-carbonyl)-2- { 5 -methyl-[ 1 ,2,4 j triazoloj 1 , 5 -ajpyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: 4-(2,2-Difluoro-2H- 1 ,3 -benzodioxole-5-carbonyl)-2- { 5-methyl- 11 ,2,4 jtriazolo [ 1 ,5 - a] pyrimidin-7-y 1 } ιηοφΐιοΐίηε ; 2- { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } -4-[3 -(pro an-2-yl)benzoyl]mo holine ; 3 ,3 -Difluoro- 1 -(6-fluoro-3 ,4-dihydro-2H- 1 -benzopyran-2-cafbonyl)-5 - { 5-methyl - [ 1 ,2,4 ] triazolo j 1 , 5 -a] pyr imidin-7-yl } piperidine ; 1 -(3 ,4-Dihydro-2H- 1 -benzopyran-2-car bonyl)-3 , 3 -difluoro-5 - { 5 -methyl-[ 1 ,2,4] triazolo [1,5- a] pyrimidin-7-y i } piperidine ; 4-(3 ,4-Dihydro-2H- 1 -benzopy ran-2-carbonyi)-2- { 5 -methyi-j 1 ,2,4 jtriazolo [ 1 ,5-a]pyrimidin-7- ν1}ΐΐΐοφ3ιοϋηε: (3,5-Dibromophenyl)(2-(5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7- }Ί)ηιο 1ιο1ϊηο)ηΐ6ί1ΐ3ηοη6-(ΐ4; 288 (3-Bromo-4-fluorophenyl)(3,3-difluoro-5-(5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl)piperidin- 1 -yl)methanone-d4; and pharmaceutically acceptable salts thereof. A chemical entity selected from the group consisting of: 3- {5-MeAyl-[l,2,4]triazolo[l ,5-a]pyrimidi (3i?)-3 - { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 -(naphthalen-2-ylmethyl)piperidine ; (35)-3-{5-Methyl-[l ,2,4]triazolo[l,5-a]pyri 7-( 1 -(3 -Bromobenzyl)piperidin-3 -yl)-5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidine ; 7-( 1 -((4 ' -Chloro-3 ,5 -difluoro-[ 1 , -biphenyl] -4-yl)methyl)piperidin-3 -yl)-5 -methyl - [1,2 ,4]triazo] o [ 1 , 5 -ajjpyrim idi ne ; 7-( 1 -([ 1 , 1 '-Biphenyl] -4-ylrnethyl)piperidin-3-yl)-5-methyl-[ 1 ,2,4]triazolo[ 1 ,5-a]pyrimidine; 1 -{ [4-(3-Chlorophenyl)-2,6-difluorophenyl]methyl}-3-{5-methyl-[ l,2,4]triazolo[ 1 ,5- a]pyrimidin-7-yl}piperidme; 1 -{ [4-(2-Chlorophenyl)-2,6-difluorophenyl]methyl}-3-{5-methyl-[ l,2,4]triazolo[ 1 ,5- a]pyrimidin-7-yl}piperidme; l-{[4-(4-Chlorophenyl)pheny]]methyl }-3-{5-methyl-[l ,2,4]tnazolo[l,5-a]pynmidin-7- yUpiperidine; l-{[4-(3-Chlorophenyl)pheny]]methy1 }-3-{5-methyl-[l ,2,4]tnazolo[l,5-a]pynmidin-7- yUpiperidine; l-{[4-(2-Chlorophenyl)pheny]]methy1 }-3-{5-methyl-[l ,2,4]tnazolo[l,5-a]pynmidin-7- yUpiperidine; l-{[4-(2-Chloro-4~fluorophenyl)pheny ]m 7-yl}piperidine; l-{[4-(4-Chlorophenyl)-2-fluorophenyl]me 7-yl}piperidine; l-{[4-(3-Chlorophenyl)-2-fluoropheny ]me^ 7-yl}piperidine; l-{[4-(2-Chlorophenyl)-2-fluoropheny ]methyl}-3-{5-methyl-[l,2,4]triazo]o[l,5-a]pyTimid 7-yl}piperidine; 4- {3-Fluoro-4-[(3-{5-methyl-[l,2,4]triazoio[l,5-a]pyriinidin-7-yi}pi^ y 1 )m eth y 3] phenyl } py ri dine ; l-{[5-(2-Chlorophenyl)-2-fluorophenyl]methyl}-3-{5-methyl-[l,2,4]triazo]o[l,5-a]pyri^ 7-yl}piperidine; 289 l-{ [5 -(2-Chloro-4-fluorophenyi)-2-fluorophenyl]meAyl }-3-{ 5 -methyl- [ 1 ,2,4]triazolo [1,5- a]pyrimidin-7-yl}piperidine; 3- {4-Fluoro-3-[(3-{5-methyl-[l,2,4]triazoio[l,5-a]pyriinidin-7-yi}pip yl)methyl]phenyl } pyri dine ; 4- {4-Fluoro-3-[(3-{5-methyl-[l,2,4]triazoio[l,5-a]pyriinidin-7-yi}piperi yl)memyljphenyl}pyndine: i - { [3 -(4-Chlorophenyl)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- yl}piperidine; i - { [3 -(3 -Chlorophenyl)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- yl}pipendine: 1 - { [3 -(2-Chlorophenyl)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- yl}piperidine; 4- { 4-[(3 - { 5 -Methyl- [ i ,2,4 jtriazolo [1,5 -a]pyrimidin-7-yl }piperidin- 1 - yl)memyljphenyl}pyridine: i - { [4-(2-Chioro-4~fluoroplienyl)-2-fluorophenyi]methyl }-3-{ 5 -methyl- [ 1 ,2,4]triazolo [1,5- a]pyrimidin-7-yl}piperidine; 1 - { [5 -(4-Chlorophenyl)-2-fluorophen}'l]methy 1 } -3 - { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1,5 -ajpyrimidin 7-yl}piperidine; i-{[5-(3-Chiorophenyi)-2-fiuoropheny^ 7-yl}piperidine; 1 - { [3 -(2-ChloiO-4-fluorophenyi)phenyl]metliy 1 } -3 - { 5 -methyl-[ 1 ,2,4 jtriazolo [ 1,5 -ajpyrimidin 7-yl}piperidine; 3-{3-Fluoro-4-[(3-{5-methyl-[l,2,4]triazolo[l,5-aJpyrimidin-7-yl}piperidin-l- yl)metliyljphenyi}pyridine: 7-(l-(2,6-Difluoro-4-(pyridin-3-yl)benz}4)piperidin-3-yl)-5-methyl-[l,2,4]triazolo[l,5- ajpyrimidine; 3- {3-[(3-{5 -Methyl- [ i ,2,4 jtriazolo [1,5 -a]pyrimidin-7-yl }piperidin- 1 - yl)metliyljphenyi}pyridine: 4- {3-[(3-{5 -Methyl- [ i ,2,4jtriazoio [1,5 -a]pyrimidin-7-yl }piperidin- 1 - yl)metliyljphenyi}pyridine: 1 -| (3 ,4-Dimethoxyphenyl)methyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5-a]pyrimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yl } - 1 -(naphthalen- 1 -y lmethyl)piperidine ; 290 1 - [(4-Chloro-2-methylphenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- yl}piperidine; 4-{4-[(3-{5-Metnyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- !)i'iK:ih> i jphenvi \ morphoHne: l-{[4-Fluoro-3-(trifluoromethyl)phenyl]methyl}-3-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin- 7-yl}piperidine; 1- {[3-(Furan-2-yl)phenyl]methyl}-3-{5-methyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine; 1 -Methyl-3 -[(3 - { 5 -methyl - [ 1 ,2,4]triazo3o [ 1 ,5 -a]pyrimidin-7-yl }piperidin-l-yl)methyl]-lH- indole; 3-{5-Methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}-l -{[4-(piperidin-l- yl)phenyl]methyl } piperidine; 3- | (3-{5-Methyl-[ l,2,4]tnazolo[L5-a]pyrimidin-7-yl}piperidin-l-yl¼ 2 - { 3 -[(3 - { 5 -Methyl- [ 1 ,2,4 jtriazolo [1,5 -a jpy rimidin-7-yl }piperidin- 1 - yl)methyl]phenyl } pyri dine ; 4- {2-[(3-{5-Methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)methyTjphenyi}mofpholine; 3- Fluoro-4-[(3-{5-metiiyl-[l,2,4]triazolo[l ,5-a]pyTimidm-7-yl}piperidin-l- yl)methyl]pyridine; 2,6-Dimethyi-3 - j (3 - { 5 -methy l-[ 1 ,2,4]triazolo [ i ,5 -aJpyrimidin-7-yl }piperidin- i - yljmetliyljpyridine; 4- [(3-{5-Methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l-yl)metliyl]pyridine; 2- j (3-{5-Methyl-[ i,2,4]triazolo[l,5-a]py 1 -| (2,4-Dichlorophenyi)methy 1 ] -3 - { 5 -methyl- [ 1 ,2,4]tnazoio [ 1 ,5 -a]pyrimidin-7-yl }piperidme; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidm-7-yi } - 1 - { j 4-( ΙΗ-pyrr ol- 1 - yl)phenyl]methyl}piperidine: 1 -( 1 -Benzothiophen-2-y lmethyl)-3 - { 5 -methyl-[ i ,2,4 jtriazolo j 1 , 5 -a jpyrimidin-7-y3}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a jpyrimidm-7-yi }-l-[(l -phenyl- ΙΗ-py razoi-4- yljmethyl Jpiperidine; 3 - { 5 -Methyl- [ 1 ,2,4 jtriazolo j 1 ,5 -a jpyrimidin-7-yi} - 1 - { [4-(pyrr olidin- 1 - yljphenyl jmethyl } piperidine : 1 - j (2, 5 -Dichlorophenyi)methy 1 ] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } piperidine; 3 - { 5 -Methyl- [ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7-yi} - 1 - { j 2-( IH-pyrazol- 1 - yljphenyl jmethyl } piperidine ; 291 1 - [(4-Chloro-2-methoxyphenyl)methyl] -3 - { 5 -methyl-[l ,2,4]triazoio [1,5 -a]py rimidin-7- yl}piperidine; 1 - [(3 -Methoxy-4 -methylphenyl)methyl] -3 - { 5-methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 1- [(2,4-Dimethoxyphenyl)metiiyl]-3-{5-me1 yl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}pipendine: 1 -(2H- 1 ,3 -Benzodioxol-4-ylmethyl)-3 - { 5 -methyl-[ 1 , 2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 1 - [(2,6-Dichlorophenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7-yl jpiperidine; 1 - { [2-( lH-Imidazol- 1 -yl)phenyl]methyl} -3- { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}piperidine; 1 - [(4-Chlorophenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7-yl}piperidine; 2- j (3 - { 5 -Methyl-[ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7-y 1 }piperidin- 1 -yl)metliyl]quinoime; l-j (2-Methoxyphenyi)memy^ l-[(4-Chloro-2,6-difluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 1 - j (2, 5 -DimethoxyphenyDmethyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5-a]pyrimidin-7- yl}pipendine: 1 -(2,3 -Dihydro- 1 ,4-benzodioxin-6-ylmethyl)-3 - { 5 -methyl .-[ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 -| (2-ChIoro-6-methylphenyl)methyl j -3 - { 5 -methyl- [ 1 ,2,4 j triazoloj 1 , 5 -ajpyrimidin-7- yl}piperidine; 1 - j (2-ChIorophenyl)methyI] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } piper idine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidm-7-yi } - i -[(4-methylphenyi)methyl]piperidine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidm-7-yI } - i - { j 3 -( IH-pyrazol- 1 - yljphenyi jmethyl } piperidine : 1 -Benzyl-3 - { 5 -methyl- [ 1 ,2,4] triazolo [1,5 -ajpyrimidin-7-yl }piperidine; 1 - j (3 -ChIoro-4-fluorophenyl)methy 1 j -3- { 5 -methyl- [ 1 ,2,4]triazolo [ 1 ,5 -aJpyrimidin-7- yl}pipendine: 3 - { 5 -Methyl-j 1 ,2,4 jtriazoio [ 1 ,5 -a jpy rimidm-7-yi } - i - { j 4-(propan-2- yloxy)phenyl]methyl}piperidine; 1 - j (2-Fiuoro-3 -methoxyphenvDmethyi] -3- { 5 -methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - j (4-Fiuoropheny l)methyl j -3 - { 5 -methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidm-7-yi } piperidine : 292 l-[(4-Chloro-3 -fluorophenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazoio [1,5 -a]py rimidin-7- yl}piperidine; 3 - { 5 -Methyl-[ 1 , 2,4Jtriazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [4-(propan-2- yl)plienyijmethy3 } piperidine: l-[(4-Methoxy-2-methylphenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: l-[(3 -Chloro-4-methoxyphenyl)methyl] -3 - { 5 -methyl-[l ,2,4]triazoio [1,5 -a]py rimidin-7- yl}piperidine; 4-[(3-{5-Methyl-[ l ,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l-yl)melliyl]-lH-indole; 1 -| (3 -Methoxyphenyl)methyl J -3 - {5 -methyl-[ 1 ,2,4]triazolo [ 1, -a]pyrimidin-7-yl}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 -[(2-methylphenyl)methyl]piperidine ; NALDimethyl-4-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l - yljmethy Γ] aniline ; 1 - j (3 ,4-Difluorophenyl)methyl] -3 - { 5-methyi- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } piper idine; l-{ [2-Fluoro-4-(trifluoromethyl)phenyl]m^ 7-yl}piperidine; 1 - | (3 ,4-Dimethy lphenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [ 1,5 -a]pyrimidin-7-y 1 } piperidine ; l-[(4~Methoxyphenyl)m.ethyl]-3-{5~m.ethyl~[l ,2,4]tnazoio[l,5-a]pynmi l-[(3-Fluoro-5-methylphenyl)melliyl]-3-{5-methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine: 1 - { [2-Methoxy-5 -(propan-2-yl)phenyl jmethyl } -3 - { 5 -methyl- j 1 ,2,4]triazolo [ 1 ,5 -ajpyrimidin- 7-yl}piperidine; 1 -(2H- 1 , 3 -Benzodioxol-5 -yimethyl)-3- { 5 -methyl-| 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yl } - 1 - [(2-pheny lphenyl)metliyl]piperidine: 3-[(3~{5-Methyl~[ l ,2,4]tnazolo[ i,5-a]pynm 1 - { [4-(Difluoromethoxy jpheny 1 Jmethyl } -3 - { 5 -methyl- j 1 ,2,4 jtriazolo j 1 ,5 -aJpyrimidin-7- yl}pipendine: 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7-yl } - 1 -[( 3 -methylphenyi)methylj piperidine; 3 - { 5 -Methyl- [ 1 ,2,4 jtriazolo j 1 ,5 -a jpy rimidin-7-yi} - 1 - { j 2- (trifluoromethyl)phenyljme thy i } piperidine ; 1 - j (2-Fiuoro-4-meihoxyphenyl)methyl J -3- { 5 -methyl- j 1 ,2,4Jtriazolo [ 1 ,5 -aJpyrimidin-7- yl}pipendine: l-(l-Benzofuran-2-ylmeihyl)-3-{5-meihyl-[ l,2,4]triazolo[i,5-a]pyrimidin-7-yl} 1 - [(2,5 -Difluorophenyl)methyl] -3 - { 5-methyl- [ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7-yl }piperidine; 3 - { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [4- (trifluoromethyl)phenyl]methyl}piperidine; l-Methyi-2-[(3~{5-inethyi-[l,2,4]tri^^ 1,3-benzodiazole; 5-Fluoro-3-[(3-{5-methyl-[l,2,4]triazolo[ l,5-a]pyrimidin-7-yl}pipeii indole; 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 -[(2-phenyl- 1 ,3 -thiazol -5 - yl)methyl]p ipe ridine ; 1 - j (3 -Chloro-4-methylphenyl)methyl ] -3 - { 5 -methyl- [ 1 ,2,4] triazoloj 1 , 5 -a]pyrimidin-7- yl}piperidine; l-[(2-Fluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidine: 1 -( 1 -Benzofuran-3 -ylmethy l)-3 - { 5-met^ l-[(3-C¾loro-2-fluorophen}4)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; l-[(3-Fluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidine: 1 -[(2, 3 -Dimethy lphenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]tnazolo [ 1 ,5 -a]pyrimidin-7-y 1 } piperidine ; l-(l-Benzothiophen-3-ylmethyl)-3-{5-me l-[(4-Fluoro-3-methox>'phenyl)metliyl]-3-{5-methyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine: 1 - | (4-Chloro-2-fluoi phenyl)methy 1] -3- { 5 -methyl- [ 1 ,2,4]triazolo [ 1 ,5 -ajpyrimidin- 7- yl}piperidine; 1- ({3,6-Dimethylmiidazo[2,l-b][ l,3]thiazo3-5-yl}methyl)-3-{5-memyl-[ l,2,4]tn^ a] pyrimidin- 7-y 1 } piperidine ; 7-( 1 -((6-Methoxynaphthalen-2-yl)methyl)piperidin-3 -yl)-5 -methyl-[ 1 ,2,4 jtriazo3o[ 1,5- a]pyrimidine; 1 - | (2,2-Difluoro-2H- 1 ,3 -benzodioxol-5 -yl)methyl] -3 - {5 -methyl- [ 1 ,2,4]triazolo [1,5- a] pyrimidin- 7-y i } piperidine ; 1 - { [3 , 5 -Dimethy i- 1 -(propan-2-yl) - 1 H-py a] pyrimidin- 7-y i } piperidine ; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidm-7-yl }-!-{[ 1-(1 ,3 -thiazol-2-yi)- lH-pyrrol-2- yljmethy 1 } piperidine ; 2- Methyl-6-[(3 - { 5-methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpyrimidm-7-yl }piperidin- 1 - yl)metliyl]pyridine; l-{[4-(Furan-2-yl)phenyl]methyl}-3-{5-methyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}piperidine; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [3 -(propan-2- yloxy)phenyl]methyl}piperidine; 4- [(3-{5-Methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l-yl)metliyl]quinoline; 1 - { [3 -(Difluoromethoxy)pheny ljmethyl } -3 - { 5 -methyl- j 1 ,2,4 jtriazolo [ 1 ,5 -ajpyrimidin-7- yl}piperidine; 1 - { [4-( 1 H-Imidazoi- 1 -yl)phenylj methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 5- Chloro-2-[(3-{5-methyl-[ l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)methyl]pyridine; 3 -Chloro-4-[(3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7-yl j iperidin- 1 - yljmethyljpyridine; 1 - j (4-Bromo-2-fluorophenyl)methy 1 j -3 - { 5 -me thyl-[ 1 ,2,4 jtriazolo [1,5 -ajpyrimidin-7- yl}piperidine; (3 ?)-l-[(4-Bromophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l ,5-a]pyrimidin-7- yl}pipendine: (35)-l-[(4-Bromophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 5 -bromo-2-[(3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 , 5-a jpyrimidin-7-yl }piperidin- 1 - yljmetliyljpyridine; 5-Bromo-4-methyl-2-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yljmetliyljpyridine; 3 -Bromo-2-methyl-6- [(3 - { 5 -methyl-j 1 ,2,4 jtriazolo 1 ,5 -ajpyrimidin-7-yl }pipendin- 1 - yljmetliyljpyridine; 5-Bromo-2-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l - yljmetliyljpyrimidine; 1 - [(4-Bromo-3 -fluoi phenyl)methy Ij -3 - { 5 -me thyl-[ 1 ,2,4 jtriazolo [1,5 -ajpyrimidin-7- yl}pipendine: (3 i)-l-[(4-C¾loro-3-fluorophenyl)memylJ-3-{5-memyl-[ l,2,4]triazolo[l,5-aJpyrimidin-7^ yl}pipendine: (35')-l-[(4-Chloro-3-fluoropheny )methyl]-3-{5-memyl-[l,2,4]triazolo[ l,5-a]py imidin-7- yl}pipendine: 295 1 -(2,3 -Dihydro- lH-inden-5 -ylmethyl)-3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidin-7- yl}piperidine; l-[(4~Bromophenyl)metliyl]~3-{5-methyl~[l ,2,4]tnazolo[l,5-a]pyrimidi l-[(4-Bromo-2,6-difluorophenyl)methyl]-3-{5-methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin-7- yl}piperidine; 1 - | (5 -Bromo-2-fluorophenyl)methy 1] -3 - { 5 -me thyl-[ 1 ,2,4 jtriazolo [1,5 -a jpyrimidin-7- yl}piperidine; l-Ethyl-6-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l-yl)methyl]- lH- indole; 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7- yl } - 1 - { [4-( 1 ,3 -thiazol-2- yl)plienyi]methy3 } piperidine: 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl } - 1 - { [4-( ΙΗ-py razol- 1 - yljphenyl jmethyl } piperidine : 3 - { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a jpy rimidm-7-yl} - 1 - { [4-(2- methylpropyl)phenyl] methyl } piperidine ; l-[(4-Bromo-3 -chlorophenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - [(4-Cyclopropylphenyl)methyl] -3 - { 5 -methyl-[ 1 ,2,4]triazolo [ 1,5 -a]py rimidin-7- yl}piperidine; l-[(4-Bromo-2-chlorophenyl)methyl]-3-{5-methyl-| 1,2,4 |triazoio[ l,5-a|pyrimidin-7- yl}pipendine: i-[(4~ er^Butyiphenyl)m.ethyi]-3-{5~methyl-[ l,2,4]triazolo[ l,5-a]pyrim.idi 7-[(3-{5-Methyl-[ l,2,4]toazolo[ l,5-a]pyrimidm l-[(2,3-Difluoro-4-methylphen}d)methyl]-3-{ 5-memyl-[l,2,4Jtriazolo[l,5-a]p}7rimidin-7^ yl}pipendine: 3 - { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a]pyrimidm-7-yl } - 1 - { [4- (trifluoromethoxy)phenyljmethyl}piperidine; 3 - { -Methyl- [ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yi} - 1 - { j 2- (trifluoromethoxy)phenyljmethyl}piperidine; 1 - { [2-Methoxy-4-(trifluoromethyl)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]tnazolo [1,5- aj pyrimidin- 7-y i } piperidine ; 7-[(3-{5-Methyl-[ l,2,4]triazolo[ l,5-a]pyrmiidin-7-yl}piperidm-l-y3)metl ^ 3 - { 5 -Methyl-[ 1 ,2,4 jtriazolo [ 1 ,5 -a jpy rimidin-7-yi} - 1 - { [4-(thiophen-2- yljphenyl jmethyl } piperidine : 296 l-[(3-Fluoro-4-methylphenyl)melliyl]-3-{5-methyl-[l ,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; l-[(2-Chloro-4-fluorophenyl)metiiyl]-3-{ 5 -methyl- [ 1 ,2,4]triazoio [1,5 -a]py rimidin-7- yl}piperidine; 1 - { [2-Methy3 -4-(trifluoromethyl)pheny3]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5- a] pyrimidin- 7-y 1 } piperidine ; l-{[4-Chloro-3-(tnfluoromethyl)phenyl]methyl}-3~{5-methyl-[l,2,4]triazolo[l ,5 7-yl}piperidine; 1 - [(4-Chloro-3 -methylphenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7- yl}pipendine; 1 - [(3 ,4 -Dichlorophenyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazolo [1,5 -a]pyrimidm-7-yl } piperidine; l-[(4-Chloro-3 -methoxyphenyl)methyl] -3 - { 5 -methyl-[ 1 ,2,4]triazoio [1,5 -a]py rimidin-7- yl}pipendine; 1 - | (3 -Bromo-4-chlorophenyl)methyl] -3 - { 5 -methyl- j 1 ,2,4 jtriazoio[ 1 ,5 -a]py rimidin-7- yl}piperidine; l-[(3-Bromo-4-metiiylphenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine; 1 - [(3 ~Bromo-4-methoxypheiiyl)methyl] -3 - { 5 -methyl- [ 1 ,2,4]triazoio [1,5 -a]pyrim idin~7~ yl}piperidine; 1 -| (3 -BiOmo-4-fluoi phenyl)methy 1 j -3 - { 5 -me thyi-[ 1 ,2,4 J triazolo [1,5 -ajpyrimidin-7- yl}pipendine; l-[(4-Bromo-3-metiiylphenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}pipendine; 1- [(4-lodophen}4)methyl]-3-{5-methyl-[l,2,4Jtriazolo[l,5-a]pyrimidin-7-yl}piperidme^ (3 i)-l-[(4-Bromo-3-fluorophen}4)methyl]-3-{5-methyl-[l,2,4Jtriazolo[l,5-aJpyrimidin-7- yl}piperidine; 3 - j (3 - { 5 -Methyl-[ 1 ,2,4]triazolo[ 1 ,5 -a]pyrimidin-7-y 1 }piperidin- 1 -yi)metliyl]benzonitnle; 2- Fluoro-5 - 1 (3 - { 5 -methyl- 11 ,2,4]triazolo [ 1 ,5 -a]pyrimidin-7-yl }piperidin- 1 - yl)metliyr]benzonitrile; 4- | (3-{5-Methyl-[ i,2,4]triazolo[l,5-a]pyrmiidin-7-yl}piperidm-l-y3)metliy^ 1 - { [3 -Fluoro-4-(triiliioromethyl)phenyl]metliy 1 } -3 - { 5 -methyl-[ 1 ,2,4 j triazolo [1,5 -ajpyrimidin- 7-yl} piperidine; (35')-l-{[3-Fluoro-4-(trifluofometh}4)pheny ]methyl}-3-{5-meth}'l-[l,2,4]triazolo[l,5- a] pyrimidin- 7-y i } piperidine ; 297 2-Me1hyl-5-[(3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7-yl}piperidin-l- yl)methyl]benzonitriie; 1 - { [3 -Fluoro-5 -(trifluoromethyl)phenyl]methyl } -3 - { 5 -methyl-[ l,2,4]triazolo[ l,5-a]pyrimidin- 7-yl}piperidine; 1- [(4-Chloro-3,5-difluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 2- Fluoro-4-[(3-{5-metiiyl-[ l,2,4]triazolo[ l ,5-a]p Timidm-7-yl}piperidin-l- yl)methyl]benzonitriie; (3i?)- l -[i4~Cli3oro~3,5~difluorophenyi)m yl}piperidine; 1 - [(3 ,5 -Difluorophenyl)metliyl] -3 - { 5-methyl- [ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7-yl }piperidine; (3 ?)- l -[(4-Bromo-3,5-difluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; 3 - { 5 -Methyl- [ 1 ,2,4]triazolo [ 1 ,5 -a jpy rimidin-7- yl} - 1 - [(3 ,4,5 - trifluorophenyl )methyl] pipers dine ; 1 - { [3 -Fluoro-4-(trifluoromethoxy)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5- a] pyrimidin- 7-y 1 } piperidine ; 1 - { [3 -Fluoro-4-( lH-pyrazol- 1 -yl)phenyl]methyl } -3 - { 5 -methyl-[ 1 ,2,4]triazolo [1,5- a]pyrimidin-7-yl}piperidine; (3,S)-l-{ [3,5-Difluoro-4-(trifluoro^ a] pyrimidin- 7-y 1 } piperidine ; (3)-:^{5-Methyl-[ l ,2,4]tnazolo[ l,5-a]pynfflidin-7-yi}-l-[(3,4,5- trifluorophenyl)methyl] pipe ndine : 3- FIuoro-5-| (3-{5-methyI-[ l,2,4]triazolo[ l,5-a]pyrimidin-7-yl}piperidin-l- yl)methyl]pyridine; 1 - [(2-Bromo- 1 ,3 -thiazol -5 -yl)methyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7- yl}piperidine: 1 - j (2-Methyl- 1 ,3 -thiazol-5 -yl)methylj -3 - { 5-methy l-[ 1 ,2,4]triazolo [ 1 ,5 -ajpyrimidin- 7- yl}piperidine: 1 - { [2-(4-Fluorophenyl)- 1 , 3-tluazol-5 -yljmethyl} -3 - { 5 -methyl-j 1 ,2,4]triazolo[l,5-a]pyrimidin 7-yl} piperidine; 1 -{ [2-(3 -Fluorophenyl)- 1 , 3-thiazol-5 -yljmethyl} -3 - { 5 -methyl-| 1 ,2,4]triazolo[l,5-a]pyrimidin 7-yl} piperidine; 298 l-{[2-(3-Methox henyl)-l,3-thiazol-5-yl]methyl}-3-{5-me l-[l,2,4]triazolo[l,5- a]pyrimidin-7-yl}piperidine; 4-{5-[(3-{5-Methyl-[l,2,4]triazolo[l,5-a]pyri yl}morpholine; 1 - [(2-Bromo- 1 ,3 -thiazol -4~yl)methyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7- yl}pipendine: 1 - [(2-Bromo- 1 ,3 -thiazol -5 -yl)methyl] -3 - { 5 -methyl -[ 1 ,2,4]triazolo [1 ,5 -a]pyrimidin-7- yl}piperidine; N^A'-Dimetliyl~5-[(3-{5~methyl-[l,2,4]triazolo[l,5-a]pyrimidm l,3-thiazol-2-amine; 3 - { 5 -Methyl-[ 1 ,2,4]triazolo [ 1 ,5-a]pyrimidin-7-yl } - 1 - { [2-(pyrrolidin- 1 -yl)- 1 ,3 -thiazol-5 - yl]methyl}piperidine; 1 - j (3 -Bromo- 1 ,2-oxazol-5 -yijmethyl J -3 - { 5 -methy l-[ 1 ,2,4]triazolo [ 1 ,5 -aJpyrimidin-7- yl}pipendine: l-[(3-Bromo-4,5-difluorophenyl)methyl]-3-{5-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-7- yl}piperidine; l-j (5-Bromo-4-methyl-l,3-thiazol-2-yl)m 7-yl}piperidine; NN,4-Trimethyl-5-[(3-{5-methyl-[l,2,4]triazoto^ l,3-thiazol-2-amine; and pharmaceutically acceptable salts thereof. 20. A pharmaceutical composition comprising: a pharmaceutically acceptable excepient; and an effective amount of at least one chemical entity selected from a compound of Fonnula (I) wherein X is -CH2- or -()-; Y is ··( ! ! - or -CF2-; Z is -Π ί - or -C( ()}··: 299 R! is a member selected from, the group consisting of: (a) phenyl unsubstituted or substituted with one, two, three, four, or five R3 members; where Ra is each independently selected from the group consisting of: -H, -halo, -Ci-ealkyl, -Ci-ehaloalkyl, -C^alkoxy, -d-ehaloalkoxy, -CN, -N(Ci-6alky!)2, -SF5, -C3-6cycloalkyl, -pyrrolidine, -morpholine, -piperidine, -pyrazole, -furan, -imidazole, -thiophene, -thiazole, -pyridine, and -phenyl, wherein phenyl is unsubstituted or substituted with one, two, three, four, or five Rb members; w here Rb is each independently selected from the group consisting of: -H, -CI and -F; or optionally two adjacent Ra members come together to form a ring, each optionally unsubstituted or substituted with one or more members independeniy selected from -H, -halo, -Ci-6alkyl, or -Ci-ealkoxy; (b) monocyclic or bicyclic heteroaromatic ring each unsubstituted or substituted with one, two, three, or four R" members; where Rc is each independently selected from the group consisting of: -H, -halo, -Ci-ealkyl, -Ci-4haloalky], -Ci-4alkoxy, -N(Ci-6a]kyl)2, -(Ci-ealkyl)cycloalky], -cyclopropyl, -morpholme, -pyrrolidine, -4-chlorophenoxy, and -phenyl optionally unsubstituted or substituted with -halo, -Chalky!, or and (c) heterocycloalkyl ring optionally unsubstituted or substituted with one or more -H, -F, or -OCH3; and pharmaceutically acceptable salts of compounds of Formula (I). 21. A pharmaceutical composition comprising: a pharmaceutically acceptable excepient; and an effective amount of at least one chemical entity of claim 18. 22. A pharmaceutical composition comprising: a pharmaceutically acceptable excepient; and an effective amount of at least one chemical entity of claim 19. 23. A method of treating a neurological disorder, comprising administering to a subject in need thereof an effective amount of a chemical entity of a claim 1, 18, or 19, wherein the neurological disorder is selected from the group consisting of a central nervous system (CNS) disorder, a developmental disorder; a schizophrenia spectrani or psychotic disorder; a depressive disorder; an anxiety disorder; an obsessive-compulsive disorder; a dissociative disorder; a disruptive, impulse-control, or conduct disorder; a 300 trauma- or stressor-related disorder; a feeding or eating disorder; a sleep-wake disorder; a sexual disorder; a substance-related or addictive disorder; and a personality disorder. 24. The method of claim 23, wherein the method is directed to a cognitive deficit due to the neurological disorder. 25. A metliod of treating a neurological disorder, comprising administering to a subject in need thereof an effective amount of a chemical entity of claim 1, 18, or 19, wherein the neurological disorder is an acquired disorder selected from the group consisting of delirium, dementia, an age-associated cognitive deficit, a trauma-dependent loss of function, and a cognitive impairment due to chemotherapy. 26. The method of claim 25, wherein said neurological disorder is dementia due to a neurodegenerative disease. 27. The method of claim 26, wherein said neurodegenerative disease is selected from the group consisting of Alzheimer's disease, Parkinson's disease, Huntington's disease, Lewy body disease, Pick's disease, a prion disease. Amyotrophic lateral sclerosis (ALS), multiple sclerosis, frontotemporal lobar degeneration, and corticobasal degeneration. 28. The method of claim 25, wherein said age-associated cognitive deficit is age-associated memory impairment (AAMI) or Mild Cognitive Impairment (MCI). 29. The method of claim 25, wherein said trauma-dependent loss of function is selected from the group consisting of stroke, traumatic brain injury (TBI), head trauma, and head injury. 30. The method of claim 29, wherein said trauma-dependent loss of function is an impairment in motor function . 31. The method of claim 29, wherein said trauma-dependent loss of function is an impairment in cognitive function. 32. A method of treating a neurological deficit during stroke rehabilitation, comprising: a. administering to a subject in need thereof a chemical entity of any one of claims 1 , 18, or 19 during recovery of said subject from stroke; b. training said subject under conditions sufficient to improve performance of a neurological function whose impairment is associated with said deficit; c. repeating steps (a) and (b) one or more times, whereby the amount of training sufficient to improve said performance is reduced compared to that produced by training 301 alone. 33. The method of claim 32, wherein said deficit is a motor deficit. 34. Tire method of claim 32, wherein said deficit is a cognitive deficit. 35. The method of claim 34, wherein said cognitive deficit is a deficit in memory formation. 36. The method of claim 35, wherein said deficit in memory formation is a deficit in long- term memory formation. 37. The method of claim 32, wherein said training comprises a battery of tasks directed to the neurological function. 38. The method of claim 32, wherein said administering step (a) occurs in conjunction with sai d training step (b) . 39. A method of treating a disorder, comprising administering to a subject in need thereof an effective amount of a chemical entity of claim 1, 18, or 19, wherein said disorder is selected from the group consisting of an infectious disease, a hematological disease, a cardiovascular disease, a gastroenterological disease, and a dermatological disease. 40. A method of treating a deficit during TBI rehabilitation, comprising: a. administering to a subject in need thereof a chemical entity of any one of claims 1, 18, or 19 during recovery of said subject from TBI; b. training said subject under conditions sufficient to improve performance of a neurological function whose impairment is due to said deficit; c. repeating steps (a) and (b) one or more times, whereby the amount of training sufficient to improve said performance is reduced compared to that produced by training alone. 41. The method of claim 40, wherein said deficit is a motor deficit. 42. The method of claim 40, wherein said deficit is a cognitive deficit. 43. The method of claim 40, wherein said TBI is a brain trauma, a head trauma, or a head injury. 44, The method of claim 40, wherein said administering step (a) occurs in conjunction with said training step (b), 45. A method of enhancing the efficiency of an animal skill training protocol, comprising: 302 a. administering to a non-human animal a chemical entity of any one of claims 1, 18, or 19; b. providing training to said non-human animal under conditions sufficient to improve performance of one or more skills: and c. repeating steps (a) and (b) one or more times, whereby the amount of training sufficient to improve said performance is reduced compared to that produced by training alone. 46. The method of claim 45, wherein said animal is a sen/ice animal. 47. The method of claim 46, wherein said service animal is a dog. 48. The method of claim 45, wherein said training protocol is directed to a single skill. 49. The method of claim 45, wherein said training protocol is directed to multiple skills. 50. The method of claim 45, wherein said administering step (a) occurs in conjunction with said training step (b). 51. A chemical entity as in claim 1, wherein the chemical entity is a compound of Formula (I), or a pharmaceutically acceptable salt of compounds of Formula (I). 52. A chemical entity as in claim 1 or 2, wherein X is -CH2- and Y is -CF2~. 53. A chemical entity as in claim 1 or 2, wherein X is -CH2- and Y is ~CH2~. 54. A chemical entity as in any one of claims 1-2 and 52-53, wherein Z is -CH2-. 55. A chemical entity as in any one of claims 1-2 and 52-53, wherein Z is -C(=0)-. 56. A chemical entity as in any one of claims 1-2 and 52-55, wherein R is -CH3. 57. A chemical entity as in any one of claims 1-2 and 52-56, wherein R1 is phenyl unsubstituted or substituted with one, two, three, four, or five Ra members. 58. A chemical entity as in any one of claims 1-2 and 52-57, wherein Rd is a member independently selected from the group consisting of: -halo, -Ci-ealkyl, -Ci-ehaloalkyl, -Ci-ealkoxy, -Cj-ehaloalkoxy, -CN, -N(Ci-6alkyl)2, and -Ci-ecycloalkyl. 59. A chemical entity as in any one of claims 1-2 and 52-57, wherein Ra is a member independently selected from: -CL -Br, -F, -I, -Ci-4haloalkoxy, -CN, -Ν(0¼)2, and -cyclopropyl. 303 60. A chemical entity as in any one of claims 1-2 and 52-57, wherein Ra is a member independently selected from: -pyrrolidine, -morpholine, -piperidine, -pyrazole, -furan, -imidazole, -thiophene, -thiazole, -pyridine, or phenyl optionally substituted with one or more -CI, or ~F. 61 . A chemical entity as in any one of claims 1 -2, 52-56 and 58-60, wherein R1 is naphthalen-l-yl, naphthalen-2-y], 6-methoxynaphthalen-2-yl, l-methoxynaphthalen-2-yl, 3- methoxynaphthalen-2-yl, 3-methoxynaphtha]ene-2-y], 6-fluoronaphthalen-2-yl, 5,6,7,8- tetrahydronaphthalen-2-yl, 5,6,7,8-tetrahydronaphthalene-2-yl, 2,3-dihydro-lH-inden-5-yl, 2.3- dihydro-lH-inden-5-yl, 2H-1 ,3-benzodioxol-4-yl, 2H-l,3-benzodioxol-5-yl, 2,3-dihydro- 1.4- benzodioxin-6-yl, 2,2-difluoro-2H-l,3-benzodioxol-5-yl, 1-ethyl-lH-indole, indole, isoquinoline, 2,3-dihydro-l -benzofuran-5-yl, 2,3-dihydro-l-benzofuran-6-yl, 3,4-dihydro- 2H-l-benzopyran-6-yl, 1-benzofuran, l -benzofuran-5-yl, l,3-benzothiazol-6-yl, or 1- benzothi ophen -5 -y] . 62. A chemical entity as in any one of claims 1-2, 52-56 and 58-60, wherein R1 is 1-( 1,3- thiazol-2-yl)-lH-pyrrol-2-yl, l-(2-chlorophenyl)-lH-pyrazol-3-yl, l-(2-fluorophenyl)-lH- pyrazol-3-yl, l -(3-bromophenyl)-lH-pyrazol-3-yl, l-(3-fluorophenyl)-lH-pyrazol-3-yl, l-(4- chlorophenyl)-5-methyl- lH-pyrazol-3-yl, 1 -(4-fluorophenyl)-5-methyl- lH-pyrazol-3-yl, 1 -(4- isopropylphenyl)-5-methyl-lH-pyrazol-3-yl, 1 ,3-benzothiazole, l,3-dimethyl-lH-pyrazol-5- yl, l,5-dimethyl-lH-pyrazol-3-yl, l,5-dimetliyl-lH-pyrazol-4-yl, l ,6-naphthyridin-2-yl, 1- benzofuran-2-yl, l-benzofuran-3-yl, l-benzothiophen-2-yl, l-benzothiophen-3-yl, 1-ethyl-lH- pyrazol-5-yl, lH-indol-3-yl, l-isopropyl-lH-pyrazol-4-yl, 1 -methyl-lH-benzo[d]imidazol-2- yl, 1 -methyl- lH-indazol-3-yl, l-methyl-lH-indol-2-yl, 1 -methyl- lH-indol-3-yl, l-methyl-3- (propan-2-yl)-lH-pyrazole, l-methyl-3-phenyl-lH-pyrazol-5-yl, l-methyl-5-phenyl-lH- pyrazol-3 -yl, 1 -phenyl- lH-pyrazol-4-yl, 1 -phenyl- 1 H-pyrazol-4-yl, 2-(3 -fl uorophenyl)- 1,3- thiazol-5-yl]methyl, 2-(3-methoxyphenyl)-l,3-thiazol-5-yl, 2-(4-chlorophenoxy)pyridin-3-yl, 2-(4-fluorophenyi)-l,3-tliiazol-5-yl, 2-(pyrrolidin-l-yl)-l,3-thiazol-5-yl, 2,4-dimethylthiazol- 5-yl, 2,6-dimethylpyridin-3-yl, 2-bromo-l,3-thiazol-4-yl, 2-bromo-l,3-thiazol-5-yl, 2- methoxypyridin-4-yl, 2-methyl-l,3-thiazol-5-yl, 2-methyl-2H-indazol-3-yl, 2-methyl-6- (trifluoromethyl)pyridin-3 -yl, 2-methylimidazo [ 1 ,2-a]pyridin-3 -yl, 2-methylpyridin-3 -yl, 2- mo jholinoihiazol-5-yl, 2-phenyl-l ,3-thiazol-5-yi, 3,5-difluoiOpyridin-2-yl, 3,5-dimethyl-l- (propan-2-yl)- lH-pyrazol-4-yl, 3,6-dimethylimidazoj 2, 1 -b] [ 1 ,3 ]thiazol-5-yl, 3-bromo- 1 ,2- oxazol-5-yl, 3-chloropyridm-4-yl, 3-cyclopropylisoxazol-5-yl, 3-fluoropyridin-4-yl, 3- isopropyl- 1 -methyl- 1 H-pyrazol-5 -yl, 3 -methylpyridin-2-yl, 3 -methylpyridin-4-yl, 4- chloropyridin-2-yl, 4-methylpyridin-2-yl, 5-bromo-4-methyl-l,3-thiazol-2-yl, 5-bromo-4- 304 methylpyridin-2-yl, 5~bromo-6-methy3pyridin-2-yl, 5-bromopyridin-2-yl, 5-bromopyrimidin- 2-yl, 5-chloropyridin-2-yl, 5-chloropyridin-3-yl, 5-cyclopropylisoxazol-3-yl, 5- cyclopropylisoxazol-4-yl, 5-fluoro-lH-indol-3-yl, 5-fluoropyridin-3-yl, 5-me1hylpyridin-3-yl, 6-methoxypyridin-3 -yl, 6-methylpyridin-2-yl, 6-methylpyridin-3 -yl, benzo [d]thiazol-2-yl, imidazo[l ,2-a]pyridin-2-yl, imidazo[l,2-a]pyridin-6-yl, isoquinolin-l-yl, isoquinolin-3-yl, N,N,4-trimethylthiazol-2 -amine, N,N-dimemylthiazol-2-amine, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, or quinoxalin-2-yl 63. A chemical entity as in any one of claims 1 -2, 52-56 and 58-60, wherein R1 is chroman- 2-yl, 6-fluorochroman-2-yl, chroman-3-yl, 7-methoxychroman-3-yl, 2,3-dihydrobenzofuran- 2-yl, (2,3-dihydrobenzo[b] [l ,4]dioxin-2-yl, or 2-metiiyl-l,2,3,4-tetrahydroisoquinolin-3-yl . 64. A chemical entity as in any one of claims 1-2, 52-56 and 58-60, wherein R1 is phenyl substituted with two or three Rd members independently selected from the group consisting of: -halo, and -Ci-ehaioaikyl. 65. A chemical entity as in any one of claims 1-2, 52-56 and 58-60, wherein Z is -C=0, -R1 is 2,3-dihydro-l-benzofuran, 3,4-dihydro-2H-l-benzopyran, benzofuran, benzothiophene, naphthalene, qumoime, or phenyl, wherein phenyl is unsubstituted or substituted with two, three, or four Ra members, where Ra is a member independently selected from: -CI, -Br, -F, -1, -Ci-4haloalkyl, -Ci-4alkoxy, -OCF2H, -CN, - N( H : ) ._ or -cyclopropyl. 66. A chemical entity as in any one of claims 1 -2, 52-56 and 58-60, wherein Z is ~CH2, -R1 is phenyl unsubstituted or substituted with two, three or four Ra members, where Ra is a member independently selected from.: -CI, -Br, -F, -I, -Chalky!, -C i -Jialoalkyl, -CN, ~N(CH3)2, or -cyclopropyl. 67. Use of a chemical entity of claim 1, 1 8, or 19 for modulating PDE2 activity. 68. Use of a chemical entity of claim 1 , 18, or 19 for treating a neurological disorder, wherein the neurological disorder is selected from the group consisting of a central nervous system (CNS) disorder, a developmental disorder; a schizophrenia spectrum or psychotic disorder; a depressive disorder; an anxiety disorder; an obsessive-compulsive disorder; a dissociative disorder; a disruptive, impulse-control, or conduct disorder; a trauma- or stressor-related disorder; a feeding or eating disorder; a sleep-wake disorder; a sexual disorder; a substance-related or addictive disorder; and a personality disorder. 69. Use of a chemical entity of claim 1 , 18, or 19 for treating a neurological disorder, 305 wherein the neurological disorder is an acquired disorder selected from the group consisting of delirium, dementia, an age-associated cognitive deficit, a trauma-dependent loss of function, and a cognitive impairment due to chemotherapy. 70. The use of claim 69, wherein said neurological disorder is dementia due to a neurodegenerative disease. 71. The use of claim 70, wherein said neurodegenerative disease is selected from the group consisting of Alzheimer's disease, Parkinson' s disease, Huntington's disease, Lewy body disease, Pick's disease, a prion disease, Amyotrophic lateral sclerosis (ALS), multiple sclerosis, frontotemporal lobar degeneration, and corticobasal degeneration. 72. The use of claim 69, wherein said age-associated cognitive deficit is age-associated memory impairment (AAMI) or Mild Cognitive Impairment (MCI). 73. The use of claim 69, wherein said trauma-dependent loss of function is selected from, the group consisting of stroke, traumatic brain injury (TBI), head trauma, and head injury. 74. The use of claim 69, wherein said trauma-dependent loss of function is an impairment in motor function, 75. The use of claim 69, wherein said trauma-dependent loss of function is an impairment in cognitive function. 76. Use of a chemical entity of claim 1, 18, or 19 for treating a neurological deficit during stroke rehabilitation. 77. The use of claim 76, wherein said deficit is a motor deficit, 78. The use of claim 76, wherein said deficit is a cognitive deficit. 79. The use of ciaim 78, wherein said cogniti ve deficit is a deficit in memory formation. 80. The use of claim 79, wherein said deficit in memory formation is a deficit in long-term memory formation. 81. Use of a chemical entity of claim 1, 18, or 19 for treating a disorder, wherein said disorder is selected from the group consisting of an infectious disease, a hematological disease, a cardiovascular disease, a gastroenterological disease, and a dermatological disease. 82. Use of a chemical entity of claim 1, 18, or 19 for treating a deficit during traniatic brain injur}' (TBI) rehabilitation. 306 83. The use of claim 82, wherein said deficit is a motor defi cit, 84. The use of claim 82, wherein said deficit is a cognitive deficit. 85. The use of claim 82, wherein said TBI is a brain trauma, a head trauma, or a head injury. 307 |
Next Patent: RAZOR CARTRIDGE GUARDS