Title:
SUBSTITUTED [1,3,5] TRIAZINE COMPOUNDS, THEIR PROCESSES FOR PREPARATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/095812
Kind Code:
A1
Abstract:
This invention discloses the substituted [1,3,5] triazine compounds of following formula,
their pharmaceutically acceptable salts and solvates or hydrates, the pharmaceutical
compositions containing the compounds and the uses thereof. The compositions
of the present invention may be used for the prevention and/or treatment of inflammation
diseases, which have good effect. The substituted [1,3,5] triazine compounds
or their pharmaceutically acceptable salts show remarkable EGFR enzyme inhibitory
activity and antitumor activity in a serious of selective tests of EGFR enzyme
level and tumor cell level (human HT-29 and HCT-116). So The compositions of the
present invention may be used for the prevention and/or treatment and/or aid
treatment of tumor diseases.
Inventors:
LIU HONG (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
DING JIAN (CN)
ZHU XINGZU (CN)
LIN LIPING (CN)
ZHENG MINGFANG (CN)
ZHENG MINGYUE (CN)
ZHOU YU (CN)
JI XINQUAN (CN)
LUO HAIBIN (CN)
LUO XIAOMIN (CN)
SHEN JIANHUA (CN)
CHEN KAIXIAN (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
DING JIAN (CN)
ZHU XINGZU (CN)
LIN LIPING (CN)
ZHENG MINGFANG (CN)
ZHENG MINGYUE (CN)
ZHOU YU (CN)
JI XINQUAN (CN)
LUO HAIBIN (CN)
LUO XIAOMIN (CN)
SHEN JIANHUA (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2006/003428
Publication Date:
August 30, 2007
Filing Date:
December 15, 2006
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
LIU HONG (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
DING JIAN (CN)
ZHU XINGZU (CN)
LIN LIPING (CN)
ZHENG MINGFANG (CN)
ZHENG MINGYUE (CN)
ZHOU YU (CN)
JI XINQUAN (CN)
LUO HAIBIN (CN)
LUO XIAOMIN (CN)
SHEN JIANHUA (CN)
CHEN KAIXIAN (CN)
LIU HONG (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
DING JIAN (CN)
ZHU XINGZU (CN)
LIN LIPING (CN)
ZHENG MINGFANG (CN)
ZHENG MINGYUE (CN)
ZHOU YU (CN)
JI XINQUAN (CN)
LUO HAIBIN (CN)
LUO XIAOMIN (CN)
SHEN JIANHUA (CN)
CHEN KAIXIAN (CN)
International Classes:
C07D251/18; A61K31/395; A61K31/435; A61K31/496; A61K31/497; A61K31/5377; A61K31/5395; A61K31/541; A61P29/00; A61P35/00; C07D251/52; C07D251/54; C07D401/04; C07D403/04; C07D413/04; C07D417/04
Domestic Patent References:
| WO2005058875A1 | 2005-06-30 |
Foreign References:
| US4269832A | 1981-05-26 | |||
| CN1625410A | 2005-06-08 | |||
| EP0263213A1 | 1988-04-13 |
Other References:
DHAINAUT A. ET AL.: "New triazine derivatives as potent modulators of multidrug resistance", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 13, 1992, pages 2481 - 2496
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (block B kingsound International Center, 116 Zizhuyuan Roa, Haidian District Beijing 7, CN)
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