Title:
SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO2010110231
Kind Code:
A1
Abstract:
Provided is a compound having an anti-viral effect, particularly an inhibitory activity on the growth of influenza viruses, more preferably a substituted 3-hydroxy-4-pyridone derivative represented by formula (I) showing an inhibitory activity on cap-dependent endonuclease. In formula (I), R1 represents hydrogen or the like; R2 represents amino, a group represented by -(CX1X2)m-Y-(CH2)n-Z (wherein X1 and X2 represent hydrogen, hydroxy, or the like; Y represents a single bond, S, or the like; m and n each independently represent 0 or an integer of 1 or more; and Z represents an organic group having a cyclic group, or the like), or the like; R3 represents carboxy or the like; and R4 represents hydrogen or the like.
Inventors:
FUJISHITA TOSHIO (JP)
MIKAMIYAMA MINAKO (JP)
KAWAI MAKOTO (JP)
AKIYAMA TOSHIYUKI (JP)
MIKAMIYAMA MINAKO (JP)
KAWAI MAKOTO (JP)
AKIYAMA TOSHIYUKI (JP)
Application Number:
PCT/JP2010/054911
Publication Date:
September 30, 2010
Filing Date:
March 23, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
FUJISHITA TOSHIO (JP)
MIKAMIYAMA MINAKO (JP)
KAWAI MAKOTO (JP)
AKIYAMA TOSHIYUKI (JP)
FUJISHITA TOSHIO (JP)
MIKAMIYAMA MINAKO (JP)
KAWAI MAKOTO (JP)
AKIYAMA TOSHIYUKI (JP)
International Classes:
C07D213/80; A61K31/4412; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/497; A61K31/506; A61K31/5377; A61P31/00; A61P31/16; A61P31/18; A61P43/00; C07D213/89; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D405/06; C07D405/10; C07D409/06; C07D409/10; C07D409/14; C07D413/06; C07D413/14; C07D417/06; C07D417/14; C07D471/04
Domestic Patent References:
| WO2006030807A1 | 2006-03-23 | |||
| WO2006030807A1 | 2006-03-23 | |||
| WO2006088173A1 | 2006-08-24 | |||
| WO2004056481A1 | 2004-07-08 | |||
| WO2006062224A1 | 2006-06-15 | |||
| WO2003005397A2 | 2003-01-16 | |||
| WO2006025783A1 | 2006-03-09 |
Foreign References:
| JPH11514966A | 1999-12-21 | |||
| GB2280435A | 1995-02-01 | |||
| EP0179667A2 | 1986-04-30 | |||
| DE1793611A1 | 1971-10-21 |
Other References:
CIANCI, C. ET AL.: "Identification of N-hydroxamic acid and N-hydroxyimide compounds that inhibit the influenza virus polymerase", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 7, no. 6, 1996, pages 353 - 360, XP002925548
TOMASSINI, J. ET AL.: "Inhibition of Cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, no. 12, 1994, pages 2827 - 2837, XP002119719
SINGH, S.B. ET AL.: "Synthesis of Natural Flutimide and Analogous Fully Substituted Pyrazine-2,6-diones, Endonuclease Inhibitors of Influenza Virus", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 16, 2001, pages 5504 - 5516, XP055100552
See also references of EP 2412708A4
TETRAHEDRON LETT, vol. 36, no. 12, 1995, pages 2005
TETRAHEDRON LETT, vol. 36, no. 12, 1995, pages 2009
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, December 1994 (1994-12-01), pages 2827 - 2837
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 1996 (1996-05-01), pages 1304 - 1307
J. MED. CHEM., vol. 46, 2003, pages 1153 - 1164
THEODORA W GREEN: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 1993, pages 15
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 3, 2008, pages 1146 - 1150
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 3, 1999, pages 369 - 374
SYNLETT, 2000, pages 1488 - 1490
JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 2, 1996, pages 123 - 32
OLGA M. ROCHOVANSKY, VIROLOGY, vol. 73, 1976, pages 327 - 338
TOMASSINI, J. ET AL.: "Inhibition of Cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, no. 12, 1994, pages 2827 - 2837, XP002119719
SINGH, S.B. ET AL.: "Synthesis of Natural Flutimide and Analogous Fully Substituted Pyrazine-2,6-diones, Endonuclease Inhibitors of Influenza Virus", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 16, 2001, pages 5504 - 5516, XP055100552
See also references of EP 2412708A4
TETRAHEDRON LETT, vol. 36, no. 12, 1995, pages 2005
TETRAHEDRON LETT, vol. 36, no. 12, 1995, pages 2009
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, December 1994 (1994-12-01), pages 2827 - 2837
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 1996 (1996-05-01), pages 1304 - 1307
J. MED. CHEM., vol. 46, 2003, pages 1153 - 1164
THEODORA W GREEN: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 1993, pages 15
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 3, 2008, pages 1146 - 1150
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 3, 1999, pages 369 - 374
SYNLETT, 2000, pages 1488 - 1490
JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 2, 1996, pages 123 - 32
OLGA M. ROCHOVANSKY, VIROLOGY, vol. 73, 1976, pages 327 - 338
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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