Title:
SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS AND METHODS FOR THE PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/093934
Kind Code:
A3
Abstract:
The invention relates to antagonists of serotonin 5-HT6 receptors / substituted [1,2,3]trirazolo[1,5-a]pyrimidines, namely to substituted 3-sulphonyl-[1,2,3]triazolo[1,5-a]quinoxylines and 3-sulphonyl-tiene[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, medicinal substances and pharmaceutical compositions which contain the medicinal substances in the form of the above-mentioned compounds, and to a method for treating and preventing the development of different cognitive and neurodegenerative diseases, including, for example, Altzheimer disease (AD) or obesity. The invention discloses antagonists of serotonin 5-HT6 receptors of general formula (1) or pharmaceutically acceptable salts and/or hydrates thereof, wherein: Ar is optionally substituted aryl or optionally substituted heterocyclyl; R1 is a hydrogen atom, a chlorine atom, a substituted sulphonyl group or an optionally substituted aminogroup; R2 and R3 together with carbon atoms, to which they are bonded, form an optionally substituted annelated benzene or thiophen ring.
More Like This:
Inventors:
IVASHCHENKO ANDREY ALEXANDROVICH (RU)
IVASHCHENKO ALEXANDER VASILIEVICH (US)
SAVCHUK NIKOLAY FILIPPOVICH (RU)
IVASHCHENKO ALEXANDER VASILIEVICH (US)
SAVCHUK NIKOLAY FILIPPOVICH (RU)
Application Number:
PCT/RU2009/000015
Publication Date:
October 15, 2009
Filing Date:
January 23, 2009
Export Citation:
Assignee:
IVASHCHENKO ANDREY ALEXANDROVI (RU)
ALLA CHEM LLC (US)
IVASHCHENKO ALEXANDER VASILIEV (US)
SAVCHUK NIKOLAY FILIPPOVICH (RU)
ALLA CHEM LLC (US)
IVASHCHENKO ALEXANDER VASILIEV (US)
SAVCHUK NIKOLAY FILIPPOVICH (RU)
International Classes:
C07D487/04; A61K31/519; A61P3/04; A61P3/08; A61P9/10; A61P25/08; A61P25/16; A61P25/18; A61P25/26; A61P25/28; C07D495/14
Domestic Patent References:
WO2008046664A1 | 2008-04-24 |
Foreign References:
RU2097382C1 | 1997-11-27 | |||
RU2189976C2 | 2002-09-27 |
Other References:
KIM HYE -JUNG ET AL.: "New Serotonine 5-HT6 Ligands from Common Feature Pharmacophore. Hypotheses.", J.OF CHEMICAL INFORMATION AND MODELING., vol. 48, no. 1, 2008, pages 197 - 206
Download PDF:
Previous Patent: HYDRODYNAMIC GENERATOR AND A REACTOR INTERNAL SYSTEM (VARIANTS)
Next Patent: A METHOD AND SYSTEM FOR BRAKING A VEHICLE
Next Patent: A METHOD AND SYSTEM FOR BRAKING A VEHICLE