Title:
SUBSTITUTED 6-AZAANDROSTENONES
Document Type and Number:
WIPO Patent Application WO1994014833
Kind Code:
A3
Abstract:
The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R<1> and R<2> i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R<1> and R<2> is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R<1> and R<2> is a single bond; R<3> is preferably hydrogen, halogen or lower alkyl, R<4> is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR<14>R<15> and R<14> and R<15> are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.
Inventors:
ANDREWS ROBERT CARL (US)
CRIBBS CYNTHIA MARKERT (US)
FRYE STEPHEN VERNON (US)
HAFFNER CURT DALE (US)
MALONEY PATRICK REED (US)
CRIBBS CYNTHIA MARKERT (US)
FRYE STEPHEN VERNON (US)
HAFFNER CURT DALE (US)
MALONEY PATRICK REED (US)
Application Number:
PCT/US1993/012419
Publication Date:
September 29, 1994
Filing Date:
December 17, 1993
Export Citation:
Assignee:
GLAXO INC (US)
ANDREWS ROBERT CARL (US)
CRIBBS CYNTHIA MARKERT (US)
FRYE STEPHEN VERNON (US)
HAFFNER CURT DALE (US)
MALONEY PATRICK REED (US)
ANDREWS ROBERT CARL (US)
CRIBBS CYNTHIA MARKERT (US)
FRYE STEPHEN VERNON (US)
HAFFNER CURT DALE (US)
MALONEY PATRICK REED (US)
International Classes:
A61P37/08; C07C211/41; A61K31/58; C07C211/45; C07D309/14; C07D317/58; C07D335/02; C07J3/00; C07J73/00; A61K; C07C; C07J; C07J63/00; C07J75/00; (IPC1-7): C07J3/00; A61K31/58; C07C211/40; C07C211/52
Domestic Patent References:
| WO1993013124A1 | 1993-07-08 |
Other References:
J. P. KUTNEY ET AL: "Aza steroids - VII. Synthesis of ring A-oxygenated 6-aza-steroids", TETRAHEDRON, vol. 24, no. 2, January 1968 (1968-01-01), OXFORD, GB, pages 845 - 857
D. VINOD ET AL: "Resolution of conflicting migratory reports in ring expansion of 3-keto steroids to oxygen and nitrogen", CANADIAN JOURNAL OF CHEMISTRY, vol. 58, no. 23, 1 December 1980 (1980-12-01), OTTAWA, CA, pages 2666 - 2678
D. VINOD ET AL: "Resolution of conflicting migratory reports in ring expansion of 3-keto steroids to oxygen and nitrogen", CANADIAN JOURNAL OF CHEMISTRY, vol. 58, no. 23, 1 December 1980 (1980-12-01), OTTAWA, CA, pages 2666 - 2678
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