SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM

Title:

SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM

Document Type and Number:

WIPO Patent Application WO/1997/024353

Kind Code:

A1

Abstract:

The disclosure relates to substituted 6-H-1,3,4-thiadiazine-2-imines of general formula (I), in which (II) represents a morpholine, thiomorpholine, piperidine, pyrrolidine or hexamethylene imine fragment, or to the pharmacologically acceptable salts of said compounds, to their use as anaesthetising, cardiovascular and hypometabolic agents and to pharmaceutical compositions containing them.

Inventors:

CHUPAKHIN OLEG NIKOLAEVICH (RU)
SIDOROVA LARISA PETROVNA (RU)
TARAKHTY EMMA AFANASIEVNA (RU)
NOVIKOVA ANTONINA PETROVNA (RU)
PEROVA NATALYA MIKHAILOVNA (RU)
VINOGRADOV VALENTIN ANTONOVICH (RU)
VAN GINKEL MICHIEL FRANCISCUS (NL)

Application Number:

PCT/RU1995/000286

Publication Date:

July 10, 1997

Filing Date:

December 28, 1995

Export Citation:

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Assignee:

PROCTER & GAMBLE (US)
LIGAND NTP TOO (RU)
CHUPAKHIN OLEG N (RU)
SIDOROVA LARISA P (RU)
TARAKHTY EMMA A (RU)
NOVIKOVA ANTONINA P (RU)
PEROVA NATALYA M (RU)
VINOGRADOV VALENTIN A (RU)
GINKEL MICHIEL F VAN (NL)

International Classes:

A61K31/54; A61K31/549; A61P9/10; A61P23/00; C07D285/16; (IPC1-7): C07D417/04; A61K31/54

Domestic Patent References:

WO1993022311A1

1993-11-11

Foreign References:

EP0276804A1	1988-08-03
RU2058307C1	1996-04-20
GB2215206A	1989-09-20
SU1827257A
US5021413A	1991-06-04
US5411955A	1995-05-02

Other References:

OSIPOVA N.A., "Otsenka Effekta Narkoticheskikh, Analgeticheskikh I Psikhotropnykh Sredsto V Klinicheskoi Anesteziologii", 1988, Meditsina, (Leningrad), pages 18-19.
"Rukovodstvo Po Anesteziologii", Pod Redaktsiei BUNYATINA A.A., 1994, Meditsina, (Moscow), pages 80-81.
"Pobochnye Deistvya Lekarstvennykh Sredstv", Pod Redaktsiei DJUKSA M.N.G., 1983, Meditsina, (Moscow), pages 89-93.

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