Title:
SUBSTITUTED ALKANOIC ACIDS
Document Type and Number:
WIPO Patent Application WO2002036553
Kind Code:
A3
Abstract:
The invention is directed to physiologically active compounds of general formula (1): wherein:- A<1> represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4 to 6 membered heterocyclic ring; R<1> represents R<3> Z<1>-Het-or R<4>N(R<5>)-C(=0)-NH-Ar<1>-; L<1> represents an R<6>-R<7>-linkage; R<2> represents hydrogen, halogen, lower alkyl or lower alkoxy; L<2> represents an alkylene linkage; Y is carboxy or an acid bioisostere; and their corresponding N-oxides or prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides or prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 ( alpha 4 beta 1).
Inventors:
HARRIS NEIL VICTOR (GB)
FENTON GARRY (GB)
FENTON GARRY (GB)
Application Number:
PCT/GB2001/004864
Publication Date:
March 13, 2003
Filing Date:
November 02, 2001
Export Citation:
Assignee:
AVENTIS PHARMA LTD (GB)
HARRIS NEIL VICTOR (GB)
FENTON GARRY (GB)
HARRIS NEIL VICTOR (GB)
FENTON GARRY (GB)
International Classes:
A61K31/195; A61K31/423; A61P11/06; A61P29/00; A61P35/00; A61P43/00; C07C275/42; C07D263/58; C07D413/12; (IPC1-7): C07C275/42; A61K31/17; C07D263/58; A61K31/423; A61P35/00
Domestic Patent References:
| WO2000015612A1 | 2000-03-23 | |||
| WO1999033789A1 | 1999-07-08 | |||
| WO1999054321A1 | 1999-10-28 |
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