Title:
SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES
Document Type and Number:
WIPO Patent Application WO2002038534
Kind Code:
A3
Abstract:
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula (I) and especially their use as inhibitors of the plasmodium falciparum protease plasmepsin II or related aspartic proteases.
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Inventors:
BOSS CHRISTOPH (CH)
FISCHLI WALTER (CH)
MEYER SOLANGE (FR)
RICHARD-BILDSTEIN SYLVIA (FR)
WELLER THOMAS (CH)
FISCHLI WALTER (CH)
MEYER SOLANGE (FR)
RICHARD-BILDSTEIN SYLVIA (FR)
WELLER THOMAS (CH)
Application Number:
PCT/EP2001/012617
Publication Date:
November 14, 2002
Filing Date:
October 31, 2001
Export Citation:
Assignee:
ACTELION PHARMACEUTICALS LTD (CH)
BOSS CHRISTOPH (CH)
FISCHLI WALTER (CH)
MEYER SOLANGE (FR)
RICHARD-BILDSTEIN SYLVIA (FR)
WELLER THOMAS (CH)
BOSS CHRISTOPH (CH)
FISCHLI WALTER (CH)
MEYER SOLANGE (FR)
RICHARD-BILDSTEIN SYLVIA (FR)
WELLER THOMAS (CH)
International Classes:
A61K31/137; A61K31/166; A61K31/17; A61K31/222; A61K31/275; A61K31/36; A61K31/4402; A61K31/505; A61K45/06; A61P33/06; A61P43/00; C07C211/27; C07C211/29; C07C217/58; C07C233/78; C07C235/50; C07C255/58; C07C255/60; C07C275/28; C07D213/38; C07D213/40; C07D239/26; C07D317/58; (IPC1-7): C07C233/78; C07C275/32; C07C217/58; C07D239/26; C07D213/38; C07D317/58; A61K31/36; A61K31/44; A61K31/165; A61K31/17; A61P33/06
Foreign References:
| DE2710047A1 | 1977-09-15 |
Other References:
GOLDENBERG, CHARLES ET AL: "Benzofurans. LX. Potential antianginal sulfonylaminobenzoylbenzofurans", EUR. J. MED. CHEM. - CHIM. THER., vol. 12, no. 1, 1977, pages 81 - 86, XP001064371
GRISAR, J. MARTIN ET AL: "Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 4. Bis basic sulfonamides of anthraquinone", J. MED. CHEM., vol. 17, no. 8, 1974, pages 890 - 893, XP000608424
PATENT ABSTRACTS OF JAPAN vol. 011, no. 317 (C - 452) 15 October 1987 (1987-10-15)
HARMSE, L. ET AL: "Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum", BIOCHEMICAL PHARMACOLOGY, vol. 62, no. 3, 2001, pages 341 - 348, XP001066310
CAULFIELD, WILSON L. ET AL: "The first potent and selective inhibitors of the glycine transporter type 2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 17, 2001, pages 2679 - 2682, XP002183670
ELSLAGER, EDWARD F. ET AL: "Antimalarial drugs. 35. Synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-2- pyrimidinyl]guanidine and related substances", J. MED. CHEM., vol. 17, no. 1, 1974, pages 75 - 100, XP002933212
GRISAR, J. MARTIN ET AL: "Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 4. Bis basic sulfonamides of anthraquinone", J. MED. CHEM., vol. 17, no. 8, 1974, pages 890 - 893, XP000608424
PATENT ABSTRACTS OF JAPAN vol. 011, no. 317 (C - 452) 15 October 1987 (1987-10-15)
HARMSE, L. ET AL: "Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum", BIOCHEMICAL PHARMACOLOGY, vol. 62, no. 3, 2001, pages 341 - 348, XP001066310
CAULFIELD, WILSON L. ET AL: "The first potent and selective inhibitors of the glycine transporter type 2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 17, 2001, pages 2679 - 2682, XP002183670
ELSLAGER, EDWARD F. ET AL: "Antimalarial drugs. 35. Synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-2- pyrimidinyl]guanidine and related substances", J. MED. CHEM., vol. 17, no. 1, 1974, pages 75 - 100, XP002933212
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