Title:
SUBSTITUTED AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2012/039460
Kind Code:
A1
Abstract:
The present invention provides a substituted amide compound such as a compound represented by formula AA, which is useful as an active ingredient of a pharmaceutical composition, especially as an active ingredient of a pharmaceutical composition for the treatment of diseases that are caused by lysophosphatidic acid (LPA). This compound has excellent LPA receptor antagonist activity.
More Like This:
Inventors:
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SAKAMOTO KAZUYUKI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SAKAMOTO KAZUYUKI (JP)
Application Number:
PCT/JP2011/071635
Publication Date:
March 29, 2012
Filing Date:
September 22, 2011
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SAKAMOTO KAZUYUKI (JP)
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SAKAMOTO KAZUYUKI (JP)
International Classes:
C07D277/20; A61K31/341; A61K31/426; A61K31/427; A61P9/00; A61P13/00; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D277/56; C07D307/68; C07D417/12
Domestic Patent References:
| WO2005058790A1 | 2005-06-30 | |||
| WO2004031118A1 | 2004-04-15 | |||
| WO2010051053A1 | 2010-05-06 | |||
| WO2011037192A1 | 2011-03-31 | |||
| WO2002062389A1 | 2002-08-15 | |||
| WO2004031118A1 | 2004-04-15 | |||
| WO2005058790A1 | 2005-06-30 | |||
| WO1999019513A2 | 1999-04-22 |
Foreign References:
| JP2009523774A | 2009-06-25 |
Other References:
See also references of EP 2620433A4
EBS LETT., vol. 523, 2002, pages 187
J. UROL., vol. 162, 1999, pages 1779
J. UROL., vol. 163, 2000, pages 1027
EUR. J. NEUROSCI., vol. 10, 1998, pages 1045
J. COMP. NEUROL., vol. 398, 1998, pages 587
PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 5233
NAT. MED., vol. 10, 2004, pages 712
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 277, 2000, pages 72
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 248, 2000, pages 436
J. CLIN. GASTROENTEROL., vol. 41, 2007, pages 616
LIFE SCI., vol. 81, 2007, pages 1009
J. AM. SOC. NEPHROL., vol. 18, 2007, pages 3110
NAT. MED., vol. 14, 2007, pages 45
PROC. NATL ACAD. SCI. U.S.A., vol. 96, 1999, pages 6931
BIOCHEM. BIOPHYSIC. RES. COMMUNIC., vol. 193, 1993, pages 497
JAMA, vol. 280, 1998, pages 719
J. NATL. CANCER. INST., vol. 93, 2001, pages 762
ENDOCRINOLOGY, vol. 147, 2006, pages 4883
PROC NATL ACAD SCI U. S. A., vol. 103, 2006, pages 9643
BIO.CHIM BIOPHYSACTA., vol. 1801, 2010, pages 1205
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Organic Synthesis", 2006, article "Greene's Protective Groups"
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, pages 619 - 622
PLOUVIER ET AL., HETEROCYCLES, vol. 32, 1991, pages 693
JOHNSON ET AL., TETRAHEDRON LETT., vol. 45, 2004, pages 8483 - 8487
EBS LETT., vol. 523, 2002, pages 187
J. UROL., vol. 162, 1999, pages 1779
J. UROL., vol. 163, 2000, pages 1027
EUR. J. NEUROSCI., vol. 10, 1998, pages 1045
J. COMP. NEUROL., vol. 398, 1998, pages 587
PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 5233
NAT. MED., vol. 10, 2004, pages 712
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 277, 2000, pages 72
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 248, 2000, pages 436
J. CLIN. GASTROENTEROL., vol. 41, 2007, pages 616
LIFE SCI., vol. 81, 2007, pages 1009
J. AM. SOC. NEPHROL., vol. 18, 2007, pages 3110
NAT. MED., vol. 14, 2007, pages 45
PROC. NATL ACAD. SCI. U.S.A., vol. 96, 1999, pages 6931
BIOCHEM. BIOPHYSIC. RES. COMMUNIC., vol. 193, 1993, pages 497
JAMA, vol. 280, 1998, pages 719
J. NATL. CANCER. INST., vol. 93, 2001, pages 762
ENDOCRINOLOGY, vol. 147, 2006, pages 4883
PROC NATL ACAD SCI U. S. A., vol. 103, 2006, pages 9643
BIO.CHIM BIOPHYSACTA., vol. 1801, 2010, pages 1205
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Organic Synthesis", 2006, article "Greene's Protective Groups"
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, pages 619 - 622
PLOUVIER ET AL., HETEROCYCLES, vol. 32, 1991, pages 693
JOHNSON ET AL., TETRAHEDRON LETT., vol. 45, 2004, pages 8483 - 8487
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
Download PDF:
Claims: