Title:
SUBSTITUTED AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/003153
Kind Code:
A1
Abstract:
Provided is a substituted amide compound represented by formula (I) [in the formula, A represents a benzene ring or the like, B represents a benzene ring or the like, W represents a hydrogen atom or the like, R1 and R2 are the same or different and represent hydrogen atoms or the like, R3 and R4 are the same or different and represent hydrogen atoms or the like, R8 represents a hydrogen atom or the like, D represents -(CH2)pY- (in the formula, p represents an integer of 0-6 and Y represents an oxygen atom or the like), E represents a linear group in which at least one CH2 group in the C3-30 alkylenes is substituted by a heteroatom group selected from -O- and the like, and G represents a hydrogen atom or the like], or a pharmaceutically acceptable salt or the like thereof.
Inventors:
SUGAWARA MASAMORI (JP)
HOSOE SHINTARO (JP)
MAEMOTO MICHIHIRO (JP)
HIRATA YUUKI (JP)
YANAGISAWA ARATA (JP)
HOSOE SHINTARO (JP)
MAEMOTO MICHIHIRO (JP)
HIRATA YUUKI (JP)
YANAGISAWA ARATA (JP)
Application Number:
PCT/JP2013/067765
Publication Date:
January 03, 2014
Filing Date:
June 28, 2013
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C07D333/68; A61K31/381; A61K31/4436; A61P3/00; A61P43/00; C07D409/12
Domestic Patent References:
| WO2011108963A1 | 2011-09-09 | |||
| WO2006057845A1 | 2006-06-01 | |||
| WO2005049604A2 | 2005-06-02 | |||
| WO2003048158A1 | 2003-06-12 | |||
| WO2002064567A2 | 2002-08-22 | |||
| WO1999000121A1 | 1999-01-07 | |||
| WO2012006475A1 | 2012-01-12 | |||
| WO2012006474A2 | 2012-01-12 | |||
| WO2012006473A1 | 2012-01-12 | |||
| WO2011136269A1 | 2011-11-03 |
Other References:
ZHANG,P. ET AL.: "Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4- (N,N-dimethylcarbamimidoyl)benzamido)-5- methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 8, 2009, pages 2179 - 2185
MENDEL,D. ET AL.: "Anthranilamide inhibitors of factor Xa", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 17, 2007, pages 4832 - 4836
RAMESHWAR,N. ET AL.: "QSAR studies of Ni-(5- chloro-2-pyridyl)-2-{[4-(alkyl methyl) benzoyl] amino}-5-chlorobenzamide analogs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, no. 2, 2006, pages 319 - 325
ZHU,B. ET AL.: "Inhibitory effect of carboxylic acid group on hERG binding", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 21, 2006, pages 5507 - 5512
ZHANG,P. ET AL.: "Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 4, 2004, pages 989 - 993
MENDEL,D. ET AL.: "Anthranilamide inhibitors of factor Xa", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 17, 2007, pages 4832 - 4836
RAMESHWAR,N. ET AL.: "QSAR studies of Ni-(5- chloro-2-pyridyl)-2-{[4-(alkyl methyl) benzoyl] amino}-5-chlorobenzamide analogs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, no. 2, 2006, pages 319 - 325
ZHU,B. ET AL.: "Inhibitory effect of carboxylic acid group on hERG binding", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 21, 2006, pages 5507 - 5512
ZHANG,P. ET AL.: "Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 4, 2004, pages 989 - 993
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