SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME

WIPO Patent Application WO/1996/005166

A1

A substituted amine derivative represented by general formula (I), having an agonistic activity on 5-HT4 receptors, and useful as a 5-HT4 receptor agonist for preventing and/or treating diseases accompanied with the insufficiency of such an agonistic activity, such as central nervous system disorder or digestive tract movement disorder, a pharmaceutically acceptable salt thereof, a medicinal composition containing the same, and an intermediate represented by general formula (IIIa) wherein ring A represents a benzene ring, a heterocycle containing N, S or O, etc.; X represents -CONR5-, etc.; R1 and R2 represent each hydrogen or lower alkyl; ring B represents a cycloalkane ring or a heterocycle containing N, S or O; and R3 and R4 represent each hydrogen or lower alkyl, or R3, R4 and the adjacent nitrogen atom are combined together to represent a heterocycle.

Suzuki
Takeshi, Imanishi
Naoki, Itahana
Hirotsune, Watanuki
Susumu, Kamato
Takeshi, Miyata
Keiji, Ohta
Mitsuaki

PCT/JP1995/001587

February 22, 1996

August 09, 1995

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Yamanouchi
Pharmaceutical
CO., LTD.
Suzuki, Takeshi
Imanishi, Naoki
Itahana, Hirotsune
Watanuki, Susumu
Kamato, Takeshi
Miyata, Keiji
Ohta, Mitsuaki

C07C237/44; C07D209/42; C07D211/58; C07D213/82; C07D215/54; C07D235/06; C07D235/26; C07D235/30; C07D265/36; C07D307/79; C07D309/14; C07D311/74; C07D319/18; C07D333/34; C07D333/38; C07D335/02; C07D471/04; (IPC1-7): C07C211/35; C07C229/64; C07C235/54; C07C237/38; C07D227/04; C07D227/06; C07D235/04; C07D235/24; C07D265/36; C07D295/12; C07D307/78; C07D309/14; C07D311/04; C07D333/34; C07D333/38; C07D335/02; C07D487/04; A61K31/165; A61K31/27; A61K31/335; A61K31/395

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