Title:
SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1996/005166
Kind Code:
A1
Abstract:
A substituted amine derivative represented by general formula (I), having an agonistic activity on 5-HT4 receptors, and useful as a 5-HT4 receptor agonist for preventing and/or treating diseases accompanied with the insufficiency of such an agonistic activity, such as central nervous system disorder or digestive tract movement disorder, a pharmaceutically acceptable salt thereof, a medicinal composition containing the same, and an intermediate represented by general formula (IIIa) wherein ring A represents a benzene ring, a heterocycle containing N, S or O, etc.; X represents -CONR5-, etc.; R1 and R2 represent each hydrogen or lower alkyl; ring B represents a cycloalkane ring or a heterocycle containing N, S or O; and R3 and R4 represent each hydrogen or lower alkyl, or R3, R4 and the adjacent nitrogen atom are combined together to represent a heterocycle.
Inventors:
SUZUKI TAKESHI (JP)
IMANISHI NAOKI (JP)
ITAHANA HIROTSUNE (JP)
WATANUKI SUSUMU (JP)
KAMATO TAKESHI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)
IMANISHI NAOKI (JP)
ITAHANA HIROTSUNE (JP)
WATANUKI SUSUMU (JP)
KAMATO TAKESHI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)
Application Number:
PCT/JP1995/001587
Publication Date:
February 22, 1996
Filing Date:
August 09, 1995
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
SUZUKI TAKESHI (JP)
IMANISHI NAOKI (JP)
ITAHANA HIROTSUNE (JP)
WATANUKI SUSUMU (JP)
KAMATO TAKESHI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)
SUZUKI TAKESHI (JP)
IMANISHI NAOKI (JP)
ITAHANA HIROTSUNE (JP)
WATANUKI SUSUMU (JP)
KAMATO TAKESHI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)
International Classes:
C07C237/44; C07D209/42; C07D211/58; C07D213/82; C07D215/54; C07D235/06; C07D235/26; C07D235/30; C07D265/36; C07D307/79; C07D309/14; C07D311/74; C07D319/18; C07D333/34; C07D333/38; C07D335/02; C07D471/04; (IPC1-7): C07C211/35; A61K31/165; A61K31/27; A61K31/335; A61K31/395; C07C229/64; C07C235/54; C07C237/38; C07D227/04; C07D227/06; C07D235/04; C07D235/24; C07D265/36; C07D295/12; C07D307/78; C07D309/14; C07D311/04; C07D333/34; C07D333/38; C07D335/02; C07D487/04
Domestic Patent References:
| WO1993003725A1 | 1993-03-04 |
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