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Title:
SUBSTITUTED AMINO KETONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2003040174
Kind Code:
A3
Abstract:
The present invention relates to compounds of the general formula (I): B-(CH--R<1>)n--C(=X<2>)-D and pharmaceutically acceptable salts thereof including steroisomers, to the use of the compounds for the treatment of impaired glucose tolerance, glucosuria, hyperlipidaemia, metabolic acidosis, diabetes mellitus, diabetic neuropathy and nephropathy and of sequelae caused by diabetes mellitus in mammals.

Inventors:
DEMUTH HANS-ULRICH (DE)
HEISER ULRICH (DE)
NIESTROJ ANDRE (DE)
HOFFMANN TORSTEN (DE)
Application Number:
PCT/EP2002/012288
Publication Date:
December 24, 2003
Filing Date:
November 04, 2002
Export Citation:
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Assignee:
PROBIODRUG AG (DE)
DEMUTH HANS-ULRICH (DE)
HEISER ULRICH (DE)
NIESTROJ ANDRE (DE)
HOFFMANN TORSTEN (DE)
International Classes:
C12N9/99; A61K31/13; A61K31/472; A61K38/04; A61K38/06; A61K38/07; A61K38/08; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P13/12; A61P17/00; A61P25/00; A61P25/08; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P29/00; A61P37/02; A61P43/00; C07C225/06; C07D217/16; C07K5/083; C07K5/087; C07K7/06; (IPC1-7): C07K5/06; A61K31/12; A61K38/04; C07C225/10
Domestic Patent References:
WO2001032624A12001-05-10
WO2001009169A22001-02-08
WO2001094310A12001-12-13
WO2001040180A22001-06-07
Foreign References:
EP1130022A12001-09-05
Other References:
KAWAMOTO A ET AL: "Enantioselective synthesis of beta-hydroxy amines and aziridines using asymmetric transfer hydrogenation of alpha-amido ketones", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 11, no. 16, 25 August 2000 (2000-08-25), pages 3257 - 3261, XP004217390, ISSN: 0957-4166
BERGMEIER S C: "The Synthesis of Vicinal Amino Alcohols", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 17, April 2000 (2000-04-01), pages 2561 - 2576, XP004197452, ISSN: 0040-4020
SENGUPTA S ET AL: "Amino Acid derived Morpholine Amides for Nucleophilic alpha-Amino Acylation Reactions: A New Synthetic Route to Enantiopure alpha-Amino Ketones", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 40, no. 21, 21 May 1999 (1999-05-21), pages 4107 - 4110, XP004164624, ISSN: 0040-4039
AUGUSTYNS K ET AL: "THE UNIQUE PROPERTIES OF DIPEPTIDYL-PEPTIDASE IV (DPP IV/CD26) AND THE THERAPEUTIC POTENTIAL OF DPP IV INHIBITORS", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 4, 1999, pages 311 - 327, XP000870290, ISSN: 0929-8673
DI GIOIA M L ET AL: "Facile approach to enantiomerically pure [alpha]-amino ketones by friedel-crafts aminoacylation and their conversion into peptidyl ketones", JOURNAL OF ORGANIC CHEMISTRY 19 OCT 2001 UNITED STATES, vol. 66, no. 21, 19 October 2001 (2001-10-19), pages 7002 - 7007, XP002242528, ISSN: 0022-3263
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