Title:
SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/135210
Kind Code:
A1
Abstract:
Disclosed are a substituted aryl compound or pharmaceutically acceptable salts thereof, a stereoisomer, a polymorphic substance, a solvate, a N-oxide, an isotopically labeled compound, a metabolite or a prodrug and a preparation method therefor and a use thereof, pharmaceutical compositions containing the compound and therapeutic use thereof. The described compound or the pharmaceutical compositions thereof can inhibit the activity of adenosine A2a receptor and can be used for treatment and prevention of diseases related to adenosine A2a receptor, specifically for treatment of tumor.
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Inventors:
LIU JINMING (CN)
HE TING (CN)
CAI JIAQIANG (CN)
LI XIAOYONG (CN)
LUO XIAOYONG (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
HE TING (CN)
CAI JIAQIANG (CN)
LI XIAOYONG (CN)
LUO XIAOYONG (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2019/126555
Publication Date:
July 02, 2020
Filing Date:
December 19, 2019
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D405/14; A61K31/444; A61K31/4545; A61K31/506; A61K31/53; A61K31/5377; A61K31/5383; A61P35/00; C07D451/02; C07D471/04; C07D498/04
Domestic Patent References:
| WO2011095625A1 | 2011-08-11 | |||
| WO2003035640A1 | 2003-05-01 | |||
| WO2019158070A1 | 2019-08-22 | |||
| WO2001062233A2 | 2001-08-30 | |||
| WO2011095625A1 | 2011-08-11 |
Foreign References:
| CN1575290A | 2005-02-02 | |||
| CN1575290A | 2005-02-02 | |||
| CN101268064A | 2008-09-17 | |||
| CN1809354A | 2006-07-26 | |||
| CN1507436A | 2004-06-23 | |||
| CN1438890A | 2003-08-27 | |||
| CN201811616858A | 2018-12-28 |
Other References:
TAKAGI, K. ET AL.: "Synthèse de Pyrimidines et de Pyrazoles à partir d'Acyl-3 halogéno-5 benzofurannes", CHEM.PHARM.BULL., vol. 23, no. 10, 31 December 1975 (1975-12-31), XP002963771, ISSN: 0009-2363, DOI: 20200305152335X
TAKAGI, K. ET AL.: "Synthèse de Pyrimidines et de Pyrazoles à partir d'Acyl-3 halogéno-5 benzofurannes", CHEM.PHARM.BULL., vol. 23, no. 10, 31 December 1975 (1975-12-31), XP002963771, ISSN: 0009-2363, DOI: 20200305154924X
TL GILCHRIST, COMPREHENSIVE ORGANIC SYNTHESIS, vol. 7, pages 748 - 750
G. W. H CHEESEMANE. S. G. WERSTIUK: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", vol. 22, 2002, ACADEMIC PRESS, pages: 390 - 392
See also references of EP 3904352A4
TAKAGI, K. ET AL.: "Synthèse de Pyrimidines et de Pyrazoles à partir d'Acyl-3 halogéno-5 benzofurannes", CHEM.PHARM.BULL., vol. 23, no. 10, 31 December 1975 (1975-12-31), XP002963771, ISSN: 0009-2363, DOI: 20200305154924X
TL GILCHRIST, COMPREHENSIVE ORGANIC SYNTHESIS, vol. 7, pages 748 - 750
G. W. H CHEESEMANE. S. G. WERSTIUK: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", vol. 22, 2002, ACADEMIC PRESS, pages: 390 - 392
See also references of EP 3904352A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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