Title:
SUBSTITUTED BENZENE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2006/003923
Kind Code:
A1
Abstract:
Disclosed is an excellent LXR modulator. Specifically disclosed are compounds represented by the following general formula (I). (In the formula, R1 represents -COR9 (wherein R9 represents an alkyl, an optionally substituted alkoxy or an optionally substituted amino or the like), an optionally substituted aryl or the like; R2 represents H, OH, an alkoxy or the like; R3 represents H, an optionally substituted alkyl, an alkenyl, an optionally substituted alkoxy, an optionally substituted amino or the like; R4 and R5 respectively represent H, an optionally substituted alkyl, a halogeno or the like; R6 and R7 respectively represent H, an alkyl or the like; R8 represents -N(R10)ZR11, -ZN(R10)R12, -X2N(R10)ZR11 or the like (wherein R10 represents H, an optionally substituted alkyl or the like, R11 represents H, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted alkenyl, an optionally substituted alkoxy, an optionally substituted amino, an optionally substituted phenyl or the like, R12 represents H, an optionally substituted alkyl, an optionally substituted alkenyl or the like, X2 represents an alkylene, and Z represents CO, CS or SO2); X1 represents a single bond or an optionally substituted methylene; and Y represents an optionally substituted phenyl or an optionally substituted heterocyclyl.)
Inventors:
YAMAGUCHI TAKAHIRO
YOSHIDA MASAYUKI
TAMAKI KAZUHIKO
YOSHIDA MASAYUKI
TAMAKI KAZUHIKO
Application Number:
PCT/JP2005/011928
Publication Date:
January 12, 2006
Filing Date:
June 29, 2005
Export Citation:
Assignee:
SANKYO CO (JP)
YAMAGUCHI TAKAHIRO
YOSHIDA MASAYUKI
TAMAKI KAZUHIKO
YAMAGUCHI TAKAHIRO
YOSHIDA MASAYUKI
TAMAKI KAZUHIKO
International Classes:
C07C233/25; C07C235/16; C07C235/46; C07C235/48; C07C237/32; C07C255/57; C07C271/16; C07C275/34; C07C311/08; C07C317/24; C07C317/46; C07C323/52
Domestic Patent References:
| WO1997014672A1 | 1997-04-24 |
Foreign References:
| US20040110947A1 | 2004-06-10 |
Other References:
KLUGE A, CAROON J. AND UNGER S. ET AL.: "Tricyclic aryl-substituted anticiccidial azauracils.", JOURAL OF MEDICINAL CHEMISTRY, vol. 21, no. 6, 1978, pages 529 - 536, XP002993076
GENTLES R. ET AL.: "Standardization and Optimized Precursor Sets for the Efficient Application of Automated Paralel Synthesis to Lead Optimization: A Mitsunobu Example.", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 4, no. 5, 2002, pages 442 - 456, XP002255800
GENTLES R. ET AL.: "Standardization and Optimized Precursor Sets for the Efficient Application of Automated Paralel Synthesis to Lead Optimization: A Mitsunobu Example.", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 4, no. 5, 2002, pages 442 - 456, XP002255800
Attorney, Agent or Firm:
Yaguchi, Toshiaki c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo 10, JP)
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