Title:
SUBSTITUTED BENZIMIDAZOLE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/102594
Kind Code:
A3
Abstract:
The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof, e.g., a pharmaceutically acceptable salt or solvate, wherein R1, R2, R3, Qa, W, U, A, B, Z, a, and the dashed lines are as defined herein, compositions comprising an effective amount of a Substituted Benzimidazole-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Benzimidazole-Type Piperidine Compound.
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Inventors:
TANAKA NOBUYUKI (JP)
YAMAWAKI KENJI (JP)
YU JIANMING (US)
ZHOU XIAOMING (US)
YAO JIANGCHAO (US)
YAMAWAKI KENJI (JP)
YU JIANMING (US)
ZHOU XIAOMING (US)
YAO JIANGCHAO (US)
Application Number:
PCT/IB2013/002884
Publication Date:
October 16, 2014
Filing Date:
December 23, 2013
Export Citation:
Assignee:
PURDUE PHARMA LP (US)
SHIONOGI & CO (JP)
TANAKA NOBUYUKI (JP)
YAMAWAKI KENJI (JP)
YU JIANMING (US)
ZHOU XIAOMING (US)
YAO JIANGCHAO (US)
SHIONOGI & CO (JP)
TANAKA NOBUYUKI (JP)
YAMAWAKI KENJI (JP)
YU JIANMING (US)
ZHOU XIAOMING (US)
YAO JIANGCHAO (US)
International Classes:
C07D401/14; A61K31/445; A61P25/04; C07D401/04; C07D451/04; C07D451/14; C07D471/04; C07D498/08
Domestic Patent References:
| WO2000006545A1 | 2000-02-10 | |||
| WO2000008013A2 | 2000-02-17 | |||
| WO2001066525A1 | 2001-09-13 | |||
| WO2002085357A1 | 2002-10-31 |
Foreign References:
| EP1069124A1 | 2001-01-17 | |||
| EP1122257A1 | 2001-08-08 | |||
| US20060030590A1 | 2006-02-09 | |||
| EP1496058A1 | 2005-01-12 |
Other References:
HAYASHI S ET AL: "Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure-activity relat", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 21, 1 November 2010 (2010-11-01), pages 7675 - 7699, XP027415422, ISSN: 0968-0896, [retrieved on 20101012]
SHIGEO HAYASHI ET AL: "Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3 R )-3-piperidinyl]-1 H -benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 3, 12 February 2009 (2009-02-12), pages 610 - 625, XP055114036, ISSN: 0022-2623, DOI: 10.1021/jm7012979
SHIGEO HAYASHI ET AL: "Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3 R )-3-piperidinyl]-1 H -benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 3, 12 February 2009 (2009-02-12), pages 610 - 625, XP055114036, ISSN: 0022-2623, DOI: 10.1021/jm7012979
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