Title:
SUBSTITUTED BENZOPYRIMIDINE OR PYRIDOPYRIMIDINE AMINE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/171018
Kind Code:
A1
Abstract:
The present invention relates to a substituted benzopyrimidine or pyridopyrimidine amine inhibitor, and a preparation method therefor and the use thereof. Specifically, the compound of the present invention has a structure as shown in formula (I). Further disclosed in the present invention are a method for preparing the compound and the use thereof as an SOS1 inhibitor. The compound of the present invention has a good selective inhibitory effect on SOS1, and has good pharmacodynamic and pharmacokinetic properties and low toxic side effects.
Inventors:
LV BINHUA (CN)
CUI DAWEI (CN)
ZHANG QING (CN)
CHAI CHUANKE (CN)
LIANG HUI (CN)
ZHANG DONGTENG (CN)
CUI DAWEI (CN)
ZHANG QING (CN)
CHAI CHUANKE (CN)
LIANG HUI (CN)
ZHANG DONGTENG (CN)
Application Number:
PCT/CN2022/074823
Publication Date:
August 18, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D403/12; A61K31/517; A61P5/00; C07D239/94; C07D401/14; C07D403/08; C07D405/12; C07D405/14; C07D487/04
Domestic Patent References:
| WO2018172250A1 | 2018-09-27 | |||
| WO2017091661A1 | 2017-06-01 | |||
| WO2018134685A2 | 2018-07-26 | |||
| WO2013003586A1 | 2013-01-03 | |||
| WO2021228028A1 | 2021-11-18 | |||
| WO2021203768A1 | 2021-10-14 | |||
| WO2021092115A1 | 2021-05-14 |
Foreign References:
| CN112105419A | 2020-12-18 | |||
| CN110167928A | 2019-08-23 |
Other References:
HILLIG ROMAN C; SAUTIER BRICE; SCHROEDER JENS; MOOSMAYER DIETER; HILPMANN ANDRÉ; STEGMANN CHRISTIAN M; WERBECK NICOLAS D; BRIEM HA: "Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 7, 12 February 2019 (2019-02-12), pages 2551 - 2560, XP055841142, ISSN: 0027-8424, DOI: 10.1073/pnas.1812963116
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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