Title:
SUBSTITUTED BRIDGED RING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/179629
Kind Code:
A1
Abstract:
The present invention relates to a substituted bridged ring inhibitor, and to a preparation method therefor and application thereof. Specifically, the compound of the present invention has the structure shown in a formula (A0), and further disclosed in the present invention are a method for preparing the compound and an application of the compound as a KRASG12D inhibitor; the compound has a good selective inhibition effect on KRASG12D, and has better pharmacodynamic and pharmacokinetic performance and lower toxic side effects.
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Inventors:
LV BINHUA (CN)
CUI DAWEI (CN)
ZHANG QING (CN)
CUI DAWEI (CN)
ZHANG QING (CN)
Application Number:
PCT/CN2023/082908
Publication Date:
September 28, 2023
Filing Date:
March 21, 2023
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D471/00; A61K31/435; A61K31/4375; A61K31/517; A61P35/00; C07D471/02; C07D471/04
Domestic Patent References:
| WO2022228568A1 | 2022-11-03 | |||
| WO2021041671A1 | 2021-03-04 | |||
| WO2022015375A1 | 2022-01-20 | |||
| WO2022042630A1 | 2022-03-03 | |||
| WO2021257736A1 | 2021-12-23 | |||
| WO2021260111A1 | 2021-12-30 | |||
| WO2022031952A2 | 2022-02-10 | |||
| WO2022051569A1 | 2022-03-10 |
Attorney, Agent or Firm:
XU & PARTNERS , LLC. et al. (CN)
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