Title:
SUBSTITUTED CARBOXYLIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/044127
Kind Code:
A1
Abstract:
Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor $g(a) (PPAR$g(a)) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preventing effect, an anti-obesity effect, a hypoglycemic effect, etc.; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1) and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R?1¿ represents trifluoromethyl, optionally substituted phenoxy, etc.; R?2¿ represents hydrogen or lower alkoxy; R?3¿, R?4¿ and R?5¿ represent each hydrogen or lower alkyl; A represents NHCO- or CONH-; X is located at the p-position concerning A and represents oxygen or sulfur, or X is located at the p-position concerning R?2¿ and represents oxygen or sulfur; and n is an integer of from 0 to 2.
Inventors:
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
MURAKAMI KOUJI (JP)
NOMURA MASAHIRO (JP)
MURAKAMI KOUJI (JP)
Application Number:
PCT/JP2001/010355
Publication Date:
June 06, 2002
Filing Date:
November 28, 2001
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
MURAKAMI KOUJI (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
MURAKAMI KOUJI (JP)
International Classes:
A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C217/84; C07C233/29; C07C233/66; C07C235/38; C07C235/60; C07C235/64; C07C271/28; (IPC1-7): C07C233/75; A61K31/19; A61K31/192; A61K31/196; A61K31/216; A61K31/22; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C233/81; C07C235/38; C07C235/46; C07C235/48; C07C235/56; C07C235/84; C07C323/52
Domestic Patent References:
| WO2001025181A1 | 2001-04-12 | |||
| WO2000075103A1 | 2000-12-14 | |||
| WO1996033036A1 | 1996-10-24 | |||
| WO1992020335A1 | 1992-11-26 | |||
| WO1992013828A1 | 1992-08-20 |
Foreign References:
| JP2000256194A | 2000-09-19 |
Attorney, Agent or Firm:
Minoura, Kiyoshi (Kudankita 3-chome Chiyoda-ku, Tokyo, JP)
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