Title:
SUBSTITUTED CYCLOALKENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/032362
Kind Code:
A1
Abstract:
It is intended to provide a substituted cycloalkene derivative represented by the general formula (I) which has an action of suppressing intracellular signal transduction or cell activation caused by endotoxin and a cell response such as hyperproduction of an inflammatory mediator caused by them, a pharmacologically acceptable salt thereof, a method for producing the same, and a pharmaceutical containing the cycloalkene derivative as an active ingredient, which is excellent in prevention and/or treatment of a disease such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure or the like). General formula (I): {In the formula, X and Y represent a group which forms the ring A with the carbon atom of the ring B to which X and Y are bound or the like. l and m independently represent an integer of 0 to 3 and l+m is 1 to 3. R1 represents an aliphatic hydrocarbon group which may be substituted or the like. n represents an integer of 0 to 3. R2 represents a hydrogen atom, an alkyl group which may be substituted or the like, R3 represents a phenyl group which may be substituted or the like, and R5 represents a hydrogen atom, an alkyl group which may be substituted or the like.}
Inventors:
KIMURA TOMIO
OHKAWA NOBUYUKI
NAGASAKI TAKAYOSHI
SUGIDACHI ATSUHIRO (JP)
ANDO OSAMU (JP)
OHKAWA NOBUYUKI
NAGASAKI TAKAYOSHI
SUGIDACHI ATSUHIRO (JP)
ANDO OSAMU (JP)
Application Number:
PCT/JP2006/318103
Publication Date:
March 22, 2007
Filing Date:
September 13, 2006
Export Citation:
Assignee:
SANKYO CO (JP)
KIMURA TOMIO
OHKAWA NOBUYUKI
NAGASAKI TAKAYOSHI
SUGIDACHI ATSUHIRO (JP)
ANDO OSAMU (JP)
KIMURA TOMIO
OHKAWA NOBUYUKI
NAGASAKI TAKAYOSHI
SUGIDACHI ATSUHIRO (JP)
ANDO OSAMU (JP)
International Classes:
C07C311/14; A61K31/215; A61K31/336; A61K31/343; A61K31/357; A61K31/385; A61K31/39; A61K31/40; A61K31/4025; A61K31/443; A61K31/5375; A61P43/00; C07D207/50; C07D303/36; C07D307/94; C07D311/96; C07D317/72; C07D319/08; C07D327/04; C07D339/06; C07D339/08; C07D405/12; C07D413/12; C07D493/10
Foreign References:
| JP2000178246A | 2000-06-27 | |||
| JP2001114751A | 2001-04-24 |
Other References:
See also references of EP 1935879A4
Attorney, Agent or Firm:
YAGUCHI, Toshiaki et al. (LIMITED 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo 10, JP)
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