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Title:
SUBSTITUTED CYCLOBUTANE COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/067709
Kind Code:
A1
Abstract:
Substituted cyclobutane compounds represented by formula I or II. The preparation method of these compounds and uses thereof as glucagons like peptide-1 receptor(GLP-1R) regulators for preventing and/or treatment of metabolic disorders, which include but not limit to diabetes, insulin-resistance and obesity etc., cardiovascular diseases and neurodegenerative diseases such as Alzheimer's diseases etc..

Inventors:
WANG, Mingwei (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
王明伟 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LI, Na (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
李娜 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Qing (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
刘青 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
Application Number:
CN2007/002768
Publication Date:
June 12, 2008
Filing Date:
September 19, 2007
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
中国科学院上海药物研究所 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
WANG, Mingwei (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
王明伟 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LI, Na (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
李娜 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Qing (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
International Classes:
C07C62/18; A61K31/19; A61K31/335; A61K31/38; A61K31/395; A61K31/435; A61K31/559; A61P3/00; A61P3/04; A61P3/10; A61P5/48; A61P9/00; A61P25/28; C07C69/74; C07C229/28; C07D213/04; C07D401/08; C07D401/14; C07D407/08; C07D407/14; C07D409/08; C07D409/14
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (11/F, Block B KingSound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 3, 201203, CN)
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