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Title:
SUBSTITUTED CYCLOBUTANE COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/067709
Kind Code:
A1
Abstract:
Substituted cyclobutane compounds represented by formula I or II. The preparation method of these compounds and uses thereof as glucagons like peptide-1 receptor(GLP-1R) regulators for preventing and/or treatment of metabolic disorders, which include but not limit to diabetes, insulin-resistance and obesity etc., cardiovascular diseases and neurodegenerative diseases such as Alzheimer's diseases etc..

Inventors:
WANG, Mingwei (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
王明伟 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LI, Na (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
李娜 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Qing (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
刘青 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
Application Number:
CN2007/002768
Publication Date:
June 12, 2008
Filing Date:
September 19, 2007
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
中国科学院上海药物研究所 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
WANG, Mingwei (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
王明伟 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LI, Na (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
李娜 (中国上海市浦东新区张江高科技园区祖冲之路555号, Shanghai 3, 201203, CN)
LIU, Qing (No.555, ZuChongZhi Road Zhangjiang Hi-Tech Park,Pudong New District, Shanghai 3, 201203, CN)
International Classes:
C07C62/18; A61K31/19; A61K31/335; A61K31/38; A61K31/395; A61K31/435; A61K31/559; A61P3/00; A61P3/04; A61P3/10; A61P5/48; A61P9/00; A61P25/28; C07C69/74; C07C229/28; C07D213/04; C07D401/08; C07D401/14; C07D407/08; C07D407/14; C07D409/08; C07D409/14
Domestic Patent References:
2006-12-28
Foreign References:
CN1626521A2005-06-15
Other References:
DATABASE CA [Online] YONGJUN CHU ET AL.: 'Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker' Database accession no. (145:118930) & TETRAHEDRON vol. 62, no. 23, 2006, pages 5536 - 5548
DATABASE CA [Online] CHANG D.Y. ET AL.: 'Reactions of halogen compounds with disodium enolate of succinosuccinic ester. 1. The reaction with iodoacetic ester' Database accession no. (50:40178) & JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, TAIWAN) vol. 2, 1955, pages 71 - 86
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (11/F, Block B KingSound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 3, 201203, CN)
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