Title:
SUBSTITUTED DIAMINOPYRIMIDINE COMPOUND AND COMPOSITION COMPRISING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/143842
Kind Code:
A1
Abstract:
The present invention provides a substituted diaminopyrimidine compound, a composition comprising the same and use thereof. The substituted diaminopyrimidine compound is a diaminopyrimidine compound represented by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate or a solvate thereof. The substituted diaminopyrimidine compound and the composition comprising the same disclosed in the present invention have excellent inhibition on EGFR kinases with improved pharmacokinetic parameters, and can increase the drug concentration of the compound in animal so as to improve drug efficacy and safety.
Inventors:
WANG YIHAN (CN)
LI HUANYIN (CN)
LI HUANYIN (CN)
Application Number:
PCT/CN2016/110913
Publication Date:
August 31, 2017
Filing Date:
December 20, 2016
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D239/48; A61K31/506; A61P3/00; A61P9/00; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06
Foreign References:
| CN103269704A | 2013-08-28 | |||
| CN106146406A | 2016-11-23 |
Download PDF:
Previous Patent: HOME VEGETABLE GARDEN PLANTING APPARATUS
Next Patent: METADATA RECOVERY METHOD AND DEVICE
Next Patent: METADATA RECOVERY METHOD AND DEVICE