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Title:
SUBSTITUTED ENAMINONES, THEIR DERIVATIVES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/108347
Kind Code:
A2
Abstract:
The invention relates to substituted enaminones of Formula (I) and their derivatives and the discovery that these compounds modulate the effect of &gammad -aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex. Formula: (I).

Inventors:
Hogenkamp, Derk J. (4510 Park Drive, Carlsbad, CA, 92008, US)
Johnstone, Timothy B. C. (2289 Santa Ana Avenue, #B Costa Mesa, CA, 92627, US)
Gee, Kelvin W. (47 Urey Court, Irvine, CA, 92612, US)
Application Number:
PCT/US2005/015869
Publication Date:
November 17, 2005
Filing Date:
May 05, 2005
Export Citation:
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Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Office of Technology Transfer, 1111 Franklin Street 5th floo, Oakland CA, 94607-5200, US)
Hogenkamp, Derk J. (4510 Park Drive, Carlsbad, CA, 92008, US)
Johnstone, Timothy B. C. (2289 Santa Ana Avenue, #B Costa Mesa, CA, 92627, US)
Gee, Kelvin W. (47 Urey Court, Irvine, CA, 92612, US)
International Classes:
C07C211/00; C07C225/16; C07C229/34; C07C237/20; C07C243/22; C07C255/58; C07D241/20; C07D249/08; C07D261/14; C07D317/66; (IPC1-7): C07C211/00
Foreign References:
US6498174B12002-12-24
Other References:
NAVARRO-VAZQUEZ ET AL., J. ORG. CHEM., vol. 67, no. 10, 2002, pages 3220
NUVOLE, A. ET AL., J CHEM. SOC. PERKIN TRANS., vol. 1, 1989, pages 1007 - 1011
DABROWSKI, J. ET AL., TETRAHEDRON, vol. 32, 1976, pages 1025 - 1029
TKINS, R. J. ET AL., ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 1, 1997, pages 185 - 197
POPIC ET AL., SYNTHESIS, 1991, pages 195 - 198
See also references of EP 1742904A4
Attorney, Agent or Firm:
Nguyen, Sam L. (Heller Ehrman LLP, 275 Middlefield Road Menlo Park, CA, 94025-3506, US)
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