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Title:
SUBSTITUTED ENAMINONES, THEIR DERIVATIVES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2005108347
Kind Code:
A3
Abstract:
The invention relates to substituted enaminones of Formula (I) and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex. Formula: (I).

Inventors:
HOGENKAMP DERK J (US)
JOHNSTONE TIMOTHY B C (US)
GEE KELVIN W (US)
Application Number:
US2005015869W
Publication Date:
July 06, 2006
Filing Date:
May 05, 2005
Export Citation:
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Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
HOGENKAMP, DERK, J.
JOHNSTONE, TIMOTHY, B., C.
GEE, KELVIN, W.
International Classes:
C07C211/00; C07C225/16; C07C229/34; C07C237/20; C07C243/22; C07C255/58; C07D241/20; C07D249/08; C07D261/14; C07D317/66
Foreign References:
ES2049640A11994-04-16
Other References:
DATABASE CAPLUS [online] SAYYED ET AL.: "An efficient synthesis of N-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids via ethyl 2-(2,2,2-trichloroethylidene)-3-oxo-3-(2-chlorophenyl)propionate", XP003012240, accession no. STN Database accession no. (2000:429756)
See also references of EP 1742904A4
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