Title:
SUBSTITUTED ETHYLENE COMPOUNDS AND DRUGS
Document Type and Number:
WIPO Patent Application WO/1997/043241
Kind Code:
A1
Abstract:
Novel substituted ethylene compounds useful as drugs, particularly as therapeutic and preventive agents for chronic articular rheumatism and other inflammatory diseases due to immune anomaly. Specifically, substituted ethylene compounds of general formula (I) or medicinally acceptable salts thereof, wherein A is a single bond or a saturated hydrocarbon chain; X is cycloalkyl, substituted phenyl or the like; Y is H or alkyl; Z is an amide linkage, a urethane linkage or the like; Ra and Rb are each independently H, halogeno or the like; Rc is carboxyl or the like; and Rd is H, halogeno or the like.
Inventors:
NAKAMURA KENICHI (JP)
NISHIMURA TAKESHI (JP)
NISHIMURA TAKESHI (JP)
Application Number:
PCT/JP1997/001581
Publication Date:
November 20, 1997
Filing Date:
May 12, 1997
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
NAKAMURA KENICHI (JP)
NISHIMURA TAKESHI (JP)
NAKAMURA KENICHI (JP)
NISHIMURA TAKESHI (JP)
International Classes:
C07C63/66; C07C233/55; C07C235/38; C07C237/42; C07C271/28; C07D257/04; (IPC1-7): C07C63/66; A61K31/085; A61K31/165; A61K31/17; A61K31/27; C07C63/74; C07C69/734; C07C69/92; C07C233/55; C07C235/38; C07C237/42; C07C271/28; C07C275/28; C07C311/08; C07C311/29; C07C311/45; C07D257/04
Foreign References:
| JPS59231058A | 1984-12-25 | |||
| US4489094A | 1984-12-18 | |||
| JPH0873404A | 1996-03-19 | |||
| JPH0987237A | 1997-03-31 | |||
| JPS6431766A | 1989-02-02 |
Other References:
CHEMICAL ABSTRACTS, Vol. 51, (1957), (Columbus, Ohio, USA), Abstract No. 17838f-17839d, SAUL PATAI et al., "Synthesis of Some Esters and Amides of beta, beta-Diarylacrylic Acids"; & J. ORG. CHEM., 21, (1956), 1379-1380.
J. MED. CHEM., Vol. 32, No. 8, (1989), ROBERT W. GUTHRIE et al., "Pentadienyl Carboxamide Derivatives as Antagonists of Platelet-Activating Factor", p. 1820-1835.
J. MED. CHEM., 11(4), (1968), B.R. BAKER et al., "Irreversible Enzyme Inhibitors. CXXVIII. p-(4,6-Diamino-1,2-Dihydro-2,2-Dimethyl-s-Triazin-1-Y1) Phenylpropionyl-Sulfanilyl Fluoride, an Active-Site-Directed Irreversible Inhibitor of Dihydrofolic Reductase. IV. Effects of Substitution on the Propionamide Bridge on Isozyme Specificity", p. 672-677.
J. MED. CHEM., Vol. 32, No. 8, (1989), ROBERT W. GUTHRIE et al., "Pentadienyl Carboxamide Derivatives as Antagonists of Platelet-Activating Factor", p. 1820-1835.
J. MED. CHEM., 11(4), (1968), B.R. BAKER et al., "Irreversible Enzyme Inhibitors. CXXVIII. p-(4,6-Diamino-1,2-Dihydro-2,2-Dimethyl-s-Triazin-1-Y1) Phenylpropionyl-Sulfanilyl Fluoride, an Active-Site-Directed Irreversible Inhibitor of Dihydrofolic Reductase. IV. Effects of Substitution on the Propionamide Bridge on Isozyme Specificity", p. 672-677.
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