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Title:
SUBSTITUTED FUSED HETEROAROMATIC BICYCLIC COMPOUNDS AS KINASE INHIBITORS AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/259601
Kind Code:
A1
Abstract:
The disclosure provides novel substituted fused heteroaromatic compounds as represented in Formula I, wherein A1-A6 and R1-R4 are defined herein. The compounds of Formula I are kinase inhibitors, especially ATR kinase inhibitors. Therefore, the compounds of the disclosure may be used to treat ATR-mediated diseases, disorders and conditions, such as cancer.

Inventors:
CAI SUI XIONG (CN)
TIAN YE EDWARD (CN)
WANG XIAOZHU (CN)
Application Number:
PCT/CN2020/098159
Publication Date:
December 30, 2020
Filing Date:
June 24, 2020
Export Citation:
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Assignee:
IMPACT THERAPEUTICS INC (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/5377; A61P35/00; C07D519/00
Domestic Patent References:
WO2020049017A12020-03-12
WO2019025440A12019-02-07
WO2013039988A12013-03-21
WO2018206547A12018-11-15
WO2012178123A12012-12-27
WO2011163527A12011-12-29
Foreign References:
CN103874700A2014-06-18
CN106795156A2017-05-31
CN1505509A2004-06-16
CN104903325A2015-09-09
CN102875549A2013-01-16
CN103068391A2013-04-24
Other References:
See also references of EP 3997087A4
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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