Title:
α-SUBSTITUTED GLYCINAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/108136
Kind Code:
A1
Abstract:
The present invention provides: a novel α-substituted glycinamide derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition containing the compound or the pharmacologically acceptable salt; and a use of the compound or the pharmacologically acceptable salt for medical purposes. The present invention provides: a compound which has a TRPM8-inhibiting activity and is represented by general formula (I) [wherein A1 represents a C6-10 aryl group or the like; A2 represents a C6-10 aryl group or the like; A3 represents a C6-10 aryl group or the like; L1 represents a single bond or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom or the like; and L2 represents a single bond or the like] or a pharmacologically acceptable salt thereof. The compound (I) according to the present invention can be used in a pharmaceutical composition for treating or preventing diseases or conditions associated with excessive excitation or damage of an afferent nerve.
Inventors:
HIRASAWA HIDEAKI (JP)
KAWAMURA NAOHIRO (JP)
KOBAYASHI JUNICHI (JP)
OZAWA TETSUJI (JP)
KAWAMURA NAOHIRO (JP)
KOBAYASHI JUNICHI (JP)
OZAWA TETSUJI (JP)
Application Number:
PCT/JP2015/051031
Publication Date:
July 23, 2015
Filing Date:
January 16, 2015
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
International Classes:
C07C237/22; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/215; A61K31/216; A61K31/277; A61K31/341; A61K31/351; A61K31/381; A61K31/401; A61K31/415; A61K31/4164; A61K31/421; A61K31/426; A61K31/433; A61K31/4353; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4965; A61P11/02; A61P13/00; A61P13/02; A61P13/10; A61P17/04; A61P25/02; A61P25/20; A61P29/00; C07C255/60; C07C311/08; C07D207/34; C07D209/42; C07D213/40; C07D213/56; C07D213/81; C07D215/48; C07D231/14; C07D233/64; C07D233/90; C07D241/24; C07D241/26; C07D263/32; C07D277/20; C07D277/30; C07D277/56; C07D285/06; C07D307/54; C07D309/08; C07D333/38
Domestic Patent References:
| WO2012120398A1 | 2012-09-13 |
Foreign References:
| JP2006508055A | 2006-03-09 | |||
| JP2000178255A | 2000-06-27 | |||
| JP2013537887A | 2013-10-07 |
Other References:
QI LIN ET AL: "Small Molecule Macroarray Construction via Ugi Four-Component Reactions", ORGANIC LETTERS, vol. 7, no. 20, 2005, pages 4455 - 4458, XP055213473
AJP- RENAL PHYSIOL, vol. 295, 2008, pages F803 - F810
AJP- RENAL PHYSIOL, vol. 295, 2008, pages F803 - F810
Attorney, Agent or Firm:
YANAGI, Nobuko et al. (JP)
Willow Nobuko (JP)
Willow Nobuko (JP)
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