Title:
Substituted guanidines and the use thereof
Document Type and Number:
WIPO Patent Application WO2001007029
Kind Code:
A3
Abstract:
A method for the treatment of cancer and pain in an animal subject is disclosed, comprising administering to said animal in need of such treatment an effective amount of a compound of formula (I), wherein R<1>-R<6> are defined herein. Pharmaceutical compositions comprising one or more compounds of formula (I) and a pharmaceutically acceptable carrier are also disclosed.
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Inventors:
LIPOWSKI ANDRZEJ W (PL)
GEE KELVIN (US)
GEE KELVIN (US)
Application Number:
PCT/US2000/019938
Publication Date:
August 23, 2001
Filing Date:
July 21, 2000
Export Citation:
Assignee:
KADMUS PHARMACEUTICALS INC (US)
International Classes:
A61K31/155; A61K31/216; A61K31/222; A61K31/223; A61K31/395; A61K31/40; A61K31/4045; A61K31/405; C07D295/12; A61K31/428; A61K31/445; A61K31/4453; A61K31/451; A61K31/495; A61K31/7008; A61P35/00; A61P43/00; C07D207/50; C07D209/16; C07D209/18; C07D209/20; C07D211/14; C07D211/52; C07D211/64; C07D273/00; C07D277/68; C07D277/82; C07H15/04; (IPC1-7): A61K31/155; A61K31/222; A61K31/7008; A61K31/445; A61K31/495; A61K31/405; A61K31/40; A61P35/00
Domestic Patent References:
| WO2000072800A2 | 2000-12-07 | |||
| WO2000072840A1 | 2000-12-07 |
Foreign References:
| US4281004A | 1981-07-28 | |||
| US3961056A | 1976-06-01 | |||
| EP0188333A1 | 1986-07-23 | |||
| US4686283A | 1987-08-11 |
Other References:
CHEMICAL ABSTRACTS, vol. 56, no. 5, 5 March 1962, Columbus, Ohio, US; column 4592; XP002159408
PATENT ABSTRACTS OF JAPAN vol. 006, no. 094 (C - 105) 2 June 1982 (1982-06-02)
HUMPHREY S J ET AL: "Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines.", METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol. 18, no. 4, 1996, pages 247 - 260, XP000981378, ISSN: 0379-0355
KISHORE V ET AL: "ANTI INFLAMMATORY AND ANTI PROTEOLYTIC PROPERTIES OF SUBSTITUTED GUANIDINES", PHARMACOLOGY (BASEL), vol. 15, no. 2, 1977, pages 97 - 103, XP000981375, ISSN: 0031-7012
SIDDIQUI N ET AL: "Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 30, no. 9, 1992, pages 811 - 813, XP000981381, ISSN: 0019-5189
KNIEPS S ET AL: "Omega-Phenyl-omega-(2-pyridyl)alkyl-substituted bisguanidines are moderate neuropeptide Y antagonists.", PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, vol. 6, no. 1, 1996, pages 27 - 30, XP000981419, ISSN: 0939-9488
M.B. DOUGHTY ET AL: "Non-peptide mimics of neuropeptide Y: A structure-activity study of benextramine analogs.", PEPT.: CHEM. STRUCT. BIOL., 1996, pages 711 - 712, XP000979231, ISSN: 0065-7727
PATENT ABSTRACTS OF JAPAN vol. 006, no. 094 (C - 105) 2 June 1982 (1982-06-02)
HUMPHREY S J ET AL: "Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines.", METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol. 18, no. 4, 1996, pages 247 - 260, XP000981378, ISSN: 0379-0355
KISHORE V ET AL: "ANTI INFLAMMATORY AND ANTI PROTEOLYTIC PROPERTIES OF SUBSTITUTED GUANIDINES", PHARMACOLOGY (BASEL), vol. 15, no. 2, 1977, pages 97 - 103, XP000981375, ISSN: 0031-7012
SIDDIQUI N ET AL: "Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 30, no. 9, 1992, pages 811 - 813, XP000981381, ISSN: 0019-5189
KNIEPS S ET AL: "Omega-Phenyl-omega-(2-pyridyl)alkyl-substituted bisguanidines are moderate neuropeptide Y antagonists.", PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, vol. 6, no. 1, 1996, pages 27 - 30, XP000981419, ISSN: 0939-9488
M.B. DOUGHTY ET AL: "Non-peptide mimics of neuropeptide Y: A structure-activity study of benextramine analogs.", PEPT.: CHEM. STRUCT. BIOL., 1996, pages 711 - 712, XP000979231, ISSN: 0065-7727
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