Title:
SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/233236
Kind Code:
A1
Abstract:
The present invention belongs to the pharmaceutical field, and specifically relates to a substituted heteroaryl compound as represented by formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, and the use of the compound and the pharmaceutical composition thereof in the preparation of drugs for treating and/or preventing proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancers, viral infectious diseases, or other diseases in mammals. The compound provided by the present invention exhibits an excellent inhibitory activity and kinase selectivity against a target kinase.
Inventors:
XI NING (US)
XU SHIMIN (CN)
WANG TINGJIN (CN)
XU SHIMIN (CN)
WANG TINGJIN (CN)
Application Number:
PCT/CN2021/094020
Publication Date:
November 25, 2021
Filing Date:
May 17, 2021
Export Citation:
Assignee:
BEIJING FINDCURE BIOSCIENCES LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
| WO2020182188A1 | 2020-09-17 | |||
| WO2018121228A1 | 2018-07-05 |
Foreign References:
| CN109348715A | 2019-02-15 | |||
| CN110627796A | 2019-12-31 | |||
| CN110511218A | 2019-11-29 | |||
| CN104974162A | 2015-10-14 |
Attorney, Agent or Firm:
HUIP PATENT ATTORNEYS (CN)
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