Title:
SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/192562
Kind Code:
A1
Abstract:
Provided are a substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for treating RIPK1-related diseases or conditions.
Inventors:
ZHOU FUSHENG (CN)
XU XIAOMING (CN)
ZHANG LEITAO (CN)
LIU ZHUBO (CN)
HU GANG (CN)
DING QIAN (CN)
XIE FUBO (CN)
ZHENG BIAO (CN)
LV QIANG (CN)
LAN JIONG (CN)
XU XIAOMING (CN)
ZHANG LEITAO (CN)
LIU ZHUBO (CN)
HU GANG (CN)
DING QIAN (CN)
XIE FUBO (CN)
ZHENG BIAO (CN)
LV QIANG (CN)
LAN JIONG (CN)
Application Number:
PCT/CN2020/080306
Publication Date:
October 01, 2020
Filing Date:
March 20, 2020
Export Citation:
Assignee:
GENFLEET THERAPEUTICS SHANGHAI INC (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
International Classes:
A61K31/428; C07D277/82; A61K31/437; A61P31/00; C07D471/04
Domestic Patent References:
| WO2018148626A1 | 2018-08-16 | |||
| WO2009017822A2 | 2009-02-05 | |||
| WO2006038116A2 | 2006-04-13 |
Foreign References:
| CN109053630A | 2018-12-21 |
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IMMUNITY, vol. 4, 1996, pages 387 - 396
NAT IMMUNOL, vol. 5, 2004, pages 503 - 507
EMBO REP, vol. 10, 2009, pages 916 - 922
J.BIOL.CHEM., vol. 274, 1999, pages 16871 - 16875
CURR.BIOL., vol. 9, 1999, pages 539 - 542
J.BIOL.CHEM., vol. 280, 2005, pages 36560 - 36566
CELL SIGNAL, vol. 27, no. 2, February 2015 (2015-02-01), pages 306 - 14
J.BIOL.CHEM., vol. 279, 2004, pages 7925 - 7933
CELL, vol. 114, 2003, pages 181 - 190
MOL.CELL, vol. 22, 2006, pages 245 - 257
J.MOL.BIOL., vol. 396, 2010, pages 528 - 539
NAT.IMMUNOL, vol. 9, 2008, pages 1037 - 1046
PROC.NATL.ACAD.SCI.USA., vol. 105, 2008, pages 11778 - 11783
SCI.SIGNAL, vol. 115, 2010, pages re4
CELL DEATH DIS, vol. 2, 2011, pages 2e115
FEBS J, vol. 278, 2012, pages 877 - 887
CELL, vol. 148, 2012, pages 228 - 243
PROC.NATL.ACAD.SCI.USA., vol. 109, 2012, pages 5322 - 5327
NAT.REV.IMMUNOL, vol. 8, 2008, pages 279 - 289
NATURE, vol. 477, 2011, pages 330 - 334
IMMUNITY, vol. 35, 2011, pages 908 - 918
PNAS, vol. 107, 2010, pages 21695 - 21700
PROC.NATL.ACAD.SCI., vol. 109, no. 36, 2012, pages 14598 - 14603
CELL, vol. 137, 2009, pages 1100 - 1111
NAT.CHEM.BIOL., vol. 1, 2005, pages 112 - 119
J.NEUROSCI.RES., vol. 88, 2010, pages 1569 - 1576
KIDNEY INT, vol. 81, 2012, pages 751 - 761
REN.FAIL., vol. 34, 2012, pages 373 - 377
NEUROCHEM.RES., vol. 37, 2012, pages 1849 - 1858
GENES DEV, vol. 27, 2013, pages 1640 - 1649
CELL HOST&MICROBE, vol. 15, 2014, pages 23 - 35
CELL, vol. 153, 2013, pages 1 - 14
"Gaucher disease", 19 January 2014, NATURE MEDICINE ADVANCE ONLINE PUBLICATION
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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