Title:
SUBSTITUTED HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2006/062249
Kind Code:
A1
Abstract:
A compound represented by the formula (1): (1) wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are defined in the present specification, a tautomer of said compound, a prodrug or pharmaceutically acceptable salt thereof or a solvated product thereof. The above compound is effective for the prevention, therapy or improvement of a disease to which the activation of a thrombopoietin receptor is effective.
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Inventors:
MIYAJI KATSUAKI (JP)
OTA HIROFUMI (JP)
HIROKAWA YUTAKA (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO SHUNSUKE (JP)
NAKANO SATOSHI (JP)
ISHIWATA NORIHISA (JP)
OTA HIROFUMI (JP)
HIROKAWA YUTAKA (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO SHUNSUKE (JP)
NAKANO SATOSHI (JP)
ISHIWATA NORIHISA (JP)
Application Number:
PCT/JP2005/022999
Publication Date:
June 15, 2006
Filing Date:
December 08, 2005
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
MIYAJI KATSUAKI (JP)
OTA HIROFUMI (JP)
HIROKAWA YUTAKA (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO SHUNSUKE (JP)
NAKANO SATOSHI (JP)
ISHIWATA NORIHISA (JP)
MIYAJI KATSUAKI (JP)
OTA HIROFUMI (JP)
HIROKAWA YUTAKA (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO SHUNSUKE (JP)
NAKANO SATOSHI (JP)
ISHIWATA NORIHISA (JP)
International Classes:
C07D333/32; A61K31/381; A61K31/425; A61P7/04; A61P43/00; C07D261/14; C07D275/02; C07D307/58; C07D307/60; C07D307/66; C07D333/40; A61K31/42; C07D207/34; C07D231/14
Domestic Patent References:
| WO2004098590A1 | 2004-11-18 | |||
| WO2001034585A1 | 2001-05-17 | |||
| WO2002049413A2 | 2002-06-27 | |||
| WO2004108683A1 | 2004-12-16 |
Foreign References:
| JPS6366170A | 1988-03-24 | |||
| JPS4744736B1 | ||||
| JP2001507002A | 2001-05-29 | |||
| JP2001518936A | 2001-10-16 | |||
| JPH10152476A | 1998-06-09 | |||
| JPH11171702A | 1999-06-29 | |||
| JPH03120255A | 1991-05-22 | |||
| US3560490A | 1971-02-02 | |||
| JPS6245570A | 1987-02-27 | |||
| JPS6461455A | 1989-03-08 |
Other References:
HUI, XIN-PING ET AL.: "Synthesis and anti bacterial actvities of 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazole derivatives of 5-methylisoxazole", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 38B, no. 9, 1999, pages 1066 - 1069, XP002996493
MOKHTAR H.M. ET AL.: "Synthesis of novel 1,3,5-trisubstituted pyrazoles as potential hypoglycemic agents", JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 35, no. 1, 1988, pages 57 - 62, XP002996494
SENER A. ET AL.: "Synthesis and some reactions of 4-benzoyl-5-phenyl-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxylic acid", TURKISH JOURNAL OF CHEMISTRY, vol. 28, no. 2, 2004, pages 149 - 156, XP002996495
AKCAMUR Y. ET AL.: "Functionalization and cyclization reactions of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 34, no. 1, 1997, pages 221 - 224, XP002996370
SENER A. ET AL.: "Studies on reactions of cyclic oxalyl compounds with hydrazines or hydrazones. 2. Synthesis and reactions of 4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 40, no. 8, 2004, pages 1039 - 1046, XP002996371
SENER A. ET AL.: "Studies on the reactions of cyclic oxalyl compounds with hydrazines or hydrazones: Synthesis and reactions of 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 39, no. 5, 2002, pages 869 - 875, XP002996372
SARIPINAR E. ET AL.: "Reactions of alpha-oxo ketenes with amides: Experimental data and semiepirical AM1 molecular orbital calculations", HETEROCYCLES, vol. 57, no. 8, 2002, pages 1445 - 1459, XP002996499
GOTTHARDT H. ET AL.: "Pyrrolo[1,2-b]-1,3,4-thiadiazole derivatives from mesomeric heteropentalenes and azodicarboxylic esters", CHEMISCHE BERICHTE, vol. 121, no. 1, 1988, pages 95 - 104, XP008062811
DURSUN K. ET AL.: "Hydrazones of some substituted pyrrole aldehydes", GLASNIK HEMICARA I TEHNOLOGA BOSNE I HERCEGOVINE, vol. 15, 1967, pages 109 - 112, XP002996901
MALINKA W. ET AL.: "Rearrangement of some N-substituted pyrrolo[3,4-c]pyrroles to corresponding pyrrolo[3,4-c]pyridines", POLISH JOURNAL OF CHEMISTRY, vol. 69, no. 1, 1995, pages 95 - 102, XP002996902
MOKHTAR H.M. ET AL.: "Synthesis of novel 1,3,5-trisubstituted pyrazoles as potential hypoglycemic agents", JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 35, no. 1, 1988, pages 57 - 62, XP002996494
SENER A. ET AL.: "Synthesis and some reactions of 4-benzoyl-5-phenyl-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxylic acid", TURKISH JOURNAL OF CHEMISTRY, vol. 28, no. 2, 2004, pages 149 - 156, XP002996495
AKCAMUR Y. ET AL.: "Functionalization and cyclization reactions of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 34, no. 1, 1997, pages 221 - 224, XP002996370
SENER A. ET AL.: "Studies on reactions of cyclic oxalyl compounds with hydrazines or hydrazones. 2. Synthesis and reactions of 4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 40, no. 8, 2004, pages 1039 - 1046, XP002996371
SENER A. ET AL.: "Studies on the reactions of cyclic oxalyl compounds with hydrazines or hydrazones: Synthesis and reactions of 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 39, no. 5, 2002, pages 869 - 875, XP002996372
SARIPINAR E. ET AL.: "Reactions of alpha-oxo ketenes with amides: Experimental data and semiepirical AM1 molecular orbital calculations", HETEROCYCLES, vol. 57, no. 8, 2002, pages 1445 - 1459, XP002996499
GOTTHARDT H. ET AL.: "Pyrrolo[1,2-b]-1,3,4-thiadiazole derivatives from mesomeric heteropentalenes and azodicarboxylic esters", CHEMISCHE BERICHTE, vol. 121, no. 1, 1988, pages 95 - 104, XP008062811
DURSUN K. ET AL.: "Hydrazones of some substituted pyrrole aldehydes", GLASNIK HEMICARA I TEHNOLOGA BOSNE I HERCEGOVINE, vol. 15, 1967, pages 109 - 112, XP002996901
MALINKA W. ET AL.: "Rearrangement of some N-substituted pyrrolo[3,4-c]pyrroles to corresponding pyrrolo[3,4-c]pyridines", POLISH JOURNAL OF CHEMISTRY, vol. 69, no. 1, 1995, pages 95 - 102, XP002996902
Attorney, Agent or Firm:
Senmyo, Kenji (38 Kanda-Higashimatsushitach, Chiyoda-ku Tokyo42, JP)
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