1 . A compound represented by Formula I:

Wherein

R¹ is selected from the group consisting of H, Ci-C₆alkyl, -(CR^a₂)_nCOOR¹¹ , -T- NHR⁵, -(CR^a₂)_nNR⁵SO₂R⁶, -(CR^a₂)_nSO₂NR⁵R⁶, -(CR^a₂)_nC(O)NR^cSO₂N(R^c)₂,

-(CR^a₂)_nC(O)NR^cSO₂R^c, -(CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, - (CR^a₂)_nNR⁵C(O)R⁶, -(CR^a₂)_nOR⁵, -(CR^a₂)_nS(O)R^c, -(CR^a₂)_nS(O)₂R^c, and nitrogen containing 5 or 6-membered heterocyclic, heteroaryl or heterocyclenyl ring, wherein the alkyl and 5 or 6-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹ , Ci-C₆alkyl, Ci-C₆haloalkyl, Ci-C₆haloalkoxy, Ci- C₆hydroxyalkyl, C₂-C₆alkenyl, Ci-C₆alkyl-C(=O)O-, C_rC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci- Cealkylamino or di(Ci-C6)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, C₃-C₈cycloalkyl, -W- (CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, or heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCi-C₆alkyl, Ci-C₆alkyl, -(CR^a₂)_zOR^c, -(CR^a₂)_zNHR⁸, - (CR^a₂)_zC(O)NR^cR^c, -(CR^a₂)_zCOOR¹⁰, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, - (CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zcyclenyl, and - (CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, -(CR^a₂)zCOOR¹⁰, Ci-C₆alkoxy, C C₆alkyl, C C₆haloalkyl, C

C₆haloalkoxy, Ci-C₆hydroxyalkyl, C₂-C₆alkenyl, Ci-C₆alkyl-C(=O)O-, CrC₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C_r Cealkylsulfonyl, Ci-C6alkylamino or di(Ci-C6)alkylamino;

R³ is selected from the group consisting of H, -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, - (CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸, - (CR^a₂)_qNR^cC(O)R⁸, -T-alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T-heterocyclic, -T- C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cydoalkyi, cydenyl and heterocydenyl can be optionally substituted with halo, SR^C, OR^c, haloCi-C₆alkyl, haloCi-C₆alkoxy, -(CR^a₂)_zCN, Ci-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, - (CR^a₂)_zC(O)OR¹¹ , -(CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, - (CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, - (CR^a₂)_zheterocyclic, -(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cydoalkyi, heterocyclic, heterocydenyl and cydenyl can further be substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹⁰, Ci-C₆alkoxy, CrC₆alkyl, C₂-C₆alkenyl, CrC₆haloalkyl, CrC₆haloalkoxy, Ci-C₆hydroxyalkyl, C_rC₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -SO₂R^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci- Cealkylamino or di(Ci-C6)alkylamino;

R⁴ is selected from the group consisting of CrC₆alkyl_, -(CR^a₂)_maryl,

-(CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)mC₃-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cydoalkyi, cydenyl, and heterocydenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , d-C₆alkoxy, C_rC₆alkyl, C₃-C₆cycloalkyl, haloC₂-C6alkenyl, C₂-C6alkenyl, C₂-C6alkenoxy, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-C₆hydroxyalkyl, CrC₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino; R⁵ is independently selected from the group consisting of H, d-Cealkyl, -Co- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- C₆alkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C3alkenyl, C3-C6cycloalkyl, Ci-C3alkoxy, OH, halo, NH₂, Ci-C3alkylamino, Ci-Csdialkylamino or COOR^{1 1} ;

R⁶ is independently selected from the group consisting of H, CrC₆alkyl, -C₀- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- Cealkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C3alkenyl, C3-C6cycloalkyl, Ci-C3alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, Ci-C₃dialkylamino or COOR^{1 1} ;

R⁷ is selected from the group consisting of H, Ci-C6alkyl, C2-C6alkenyl, C3- Cscycloalkyl, aryl, heteroaryl, heterocyclic, wherein the alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, C Cehaloalkyl, Ci-Cehaloalkoxy, C2-C6alkenyl, C2-C6alkynyl, Ci-C6alkyl, -Co-C6alkyl- Cs-Cscycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, -Co-C6alkylheterocyclic, - Co-C₆alkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNR⁵R⁶, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)_zSO₂NR⁵R⁶, -(CR^a₂)_zC(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)_zNR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, and - (CR^a₂)zS(O)₂R^c;

R⁸ is independently selected from the group consisting of H, -(CR^a2)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a2)_sC3-C₇cycloalkyl, and Ci-C6alkyl, wherein the heteroaryl, aryl, heterocyclic, heterocydenyl, cydenyl, cycloalkyl, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR^{1 1} , Ci-C₆alkoxy, CrC₆alkyl, C₂-C₆alkenyl, heterocyclic, Ci-C₆haloalkyl, Ci-C₆haloalkoxy, Ci-C₆hydroxyalkyl, Ci-C₆alkyl- C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R⁹ is independently selected from the group consisting of H, Ci-C₆alkyl, C

Cehaloalkyl, Cs-Cscycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, cydoalkyi, aryl, heteroaryl, and heterocyclic can be optionally substituted with -Co- C₆alkylOR^c, -C₀-C₆alkylN(R^c)₂, COOR¹⁰, nitro, CN, Ci-C₆alkyl, C C₆haloalkyl, Ci- C₆haloalkoxy, C_rC₆hydroxyalkyl, C₂-C₆alkenyl, d-C₆alkyl-C(=O)O-, C_rC₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d- C₆alkylsulfonyl, heterocyclic, or C(O)NHR^c;

R¹⁰ is independently selected from the group consisting of CrC₆alkyl, -(CR^C₂)_ZC₃- Cscycloalkyl, -(CR^c₂)_z-heteroaryl, -(CR^c₂)_z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with Ci-C₆alkyl, OH, halo, or haloCrC₆alkyl;

R¹¹ is independently selected from the group consisting of H, d-Cealkyl, - (CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with CrC₆alkyl, Ci-C₆alkoxy, OH, halo, or haloCrC₆alkyl;

R¹⁷ is independently selected from the group consisting of H, halo, COOH, oxadiazolone, CrC₆alkyl, Ci-C₆alkoxy, NR^CR^C, -(CR^c₂)_zC₃-C₈cycloalkyl, - (CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with CrC₆alkyl, OH, halo, or haloCrC₆alkyl;

R^a is independently H , C(O)NR^c₂, OR^c, NH₂, halo, Ci-C₆alkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, Ci-C alkoxy, NH₂, halo, haloCr C₄alkyl, C₃-C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or Ci-C₄alkyl optionally substituted with C₂-C₃alkenyl, C₃- C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or Ci-C₃dialkylamino;

T is independently C₂-C₃alkenyl, -C(O)-, -(CR^a₂)_q-_, -C(=CH₂)-, -(CR^a₂)_q-C(=CH₂)-, -C(=CH₂)-(CR^a₂)_q-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^C-; U is H, COOR¹¹ , OH, heteroaryl or heterocyclic; n is independently 0, 1 , 2 or 3;

m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 represented by Formula I:

Wherein

R¹ is selected from the group consisting of H, d-C₆alkyl, -(CR^a₂)_nCOOR¹¹ , -T- NHR⁵, -(CR^a₂)_nNR⁵SO₂R⁶, -(CR^a₂)_nSO₂NR⁵R⁶, -(CR^a₂)_nC(O)NR^cSO₂N(R^c)₂,

-(CR^a₂)_nC(O)NR^cSO₂R^c, -(CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, - (CR^a₂)_nNR⁵C(O)R⁶, -(CR^a₂)_nOR⁵, -(CR^a₂)_nS(O)R^c, -(CR^a₂)_nS(O)₂R^c, and nitrogen containing 5 or 6-membered heterocyclic, heteroaryl or heterocyclenyl ring, wherein the alkyl and 5 or 6-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹ , Ci-C₆alkyl, Ci-C₆haloalkyl, Ci-C₆haloalkoxy, Ci- Cehydroxyalkyl, C₂-C₆alkenyl, Ci-C₆alkyl-C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci- Cealkylamino or di(Ci-C6)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, -W-(CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, or heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCi-C₆alkyl, d-C₆alkyl, -(CR^a₂)_zOR^c, -(CR^a₂)_zNHR⁸, -(CR^a₂)_zC(O)NR^cR^c, - (CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃-C₈cycloalkyl, - (CR^a₂)_zcyclenyl, and -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, -(CR^a₂)_zCOOR¹⁰, Ci-C₆alkoxy, C_r Cealkyl, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, d-Cehydroxyalkyl, C₂-C6alkenyl, Ci- C6alkyl-C(=O)O-, Ci-C6alkyl-C(=O)-, C₂-C6alkynyl, halo group, hydroxyalkoxy, - SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R³ is selected from the group consisting of H, -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, - (CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸, - (CR^a₂)_qNR^cC(O)R⁸, -T-alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T-heterocyclic, -T- C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl can be optionally substituted with halo, OR^c, halod-Cealkyl, halod- C₆alkoxy, -(CR^a₂)_zCN, Ci-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR¹¹ , - (CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR^cR⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, heterocyclic, heterocyclenyl and cyclenyl can further be substituted with OH, NH₂, nitro, CN, CON(R^c)₂,

COOR¹⁰, Ci-C₆alkoxy, d-C₆alkyl, C₂-C₆alkenyl, Ci-C₆haloalkyl, Ci-C₆haloalkoxy, Ci-Cehydroxyalkyl, Ci-C₆alkyl-C(=O)O-, d-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d-C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino; R⁴ is selected from the group consisting of d-Cealkyl_, -(CR^a2)_maryl, - (CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)mC3-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyl, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR^{1 1} , Ci-C₆alkoxy, CrC₆alkyl, C₃-C₆cycloalkyl, haloC₂-C6alkenyl, C₂-C6alkenyl, C₂-C6alkenoxy, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-C₆hydroxyalkyl, C_rC₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C6)alkylamino;

R⁵ is independently selected from the group consisting of H, CrC₆alkyl, -C₀- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- Cealkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C3alkenyl, C3-C6cycloalkyl, Ci-C₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, Ci-C₃dialkylamino or COOR^{1 1} ;

R⁶ is independently selected from the group consisting of H, Ci-C6alkyl, -Co- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- Cealkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C₃alkenyl, C₃-C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, Ci-C₃dialkylamino or COOR^{1 1} ;

R⁷ is selected from the group consisting of H, Ci-C6alkyl, C₂-C6alkenyl, C₃- Cscycloalkyl, aryl, heteroaryl, heterocyclic, wherein the alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, Ci- Cehaloalkyl, Ci-Cehaloalkoxy, C₂-C6alkenyl, C₂-C6alkynyl, Ci-C6alkyl, -Co-C6alkyl- C₃-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, -Co-C6alkylheterocyclic, - C₀-C₆alkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNR⁵R⁶, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)_zSO₂NR⁵R⁶, -(CR^a₂)_zC(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)_zNR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, and - (CR^a₂)_zS(O)₂R^c; R is independently selected from the group consisting of H, -(CR^a2)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a₂)sC₃-C₇cycloalkyl, and Ci-C₆alkyl, wherein the heteroaryl, aryl, heterocyclic, heterocydenyl, cydenyl, cydoalkyi, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR^{1 1} , Ci-C₆alkoxy, CrC₆alkyl, C₂-C₆alkenyl, d- C₆haloalkyl, Ci-C₆haloalkoxy, Ci-C₆hydroxyalkyl, CrC₆alkyl-C(=O)O-, d-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C_r Cealkylsulfonyl, Ci-C6alkylamino or di(Ci-C6)alkylamino;

R⁹ is independently selected from the group consisting of H, Ci-Cealkyl, Ci- C₆haloalkyl, C₃-C₈cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, cydoalkyi, aryl, heteroaryl, and heterocyclic can be optionally substituted with -Co- C₆alkylOR^c, -C₀-C₆alkylN(R^c)₂, COOR¹⁰, nitro, CN, Ci-C₆alkyl, C C₆haloalkyl, Ci- C₆haloalkoxy, CrC₆hydroxyalkyl, C₂-C₆alkenyl, Ci-C₆alkyl-C(=O)O-, d-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C_r C₆alkylsulfonyl, heterocyclic, or C(O)NHR^c;

R¹⁰ is independently selected from the group consisting of d-Cealkyl, -(CR^C₂)_ZC3- Cscycloalkyl, -(CR^c₂)_z-heteroaryl, -(CR^c₂)_z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with Ci-C₆alkyl, OH, halo, or haloCrC₆alkyl;

R^{1 1} is independently selected from the group consisting of H, d-Cealkyl, - (CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with d-Cealkyl, OH, halo, or haloCi-Cealkyl;

R¹⁷ is independently selected from the group consisting of H, halo, COOH, oxadiazolone, Ci-C₆alkyl, -(CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with d-Cealkyl, OH, halo, or haloCi-Cealkyl; R^a is independently H , C(O)NR^c₂, OR^c, NH₂, halo, Ci-C₆alkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, Ci-C₄alkoxy, NH₂, halo, haloCi- C₄alkyl, C₃-C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or Ci-C₄alkyl optionally substituted with C₂-C3alkenyl, C3- C6cycloalkyl, Ci-C3alkoxy, OH, halo, NH₂, Ci-C3alkylamino, or CrCsdialkylamino;

T is independently C₂-C₃alkenyl, -C(O)-, -(CR^a₂)_q-_, -C(=CH₂)-, -(CR^a₂)_q-C(=CH₂)-, -C(=CH₂)-(CR^a₂)_q-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^C-;

U is H, COOR¹¹ , OH, heteroaryl or heterocyclic; n is independently 0, 1 , 2 or 3;

m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2,

Wherein

R¹ is selected from the group consisting of d-C₆alkyl, -(CR^a₂)_nCOOR¹¹ , -T-NHR⁵, - (CR^a₂)_nNR⁵SO₂R⁶, -(CR^a₂)_nSO₂NR⁵R⁶, -(CR^a₂)_nC(O)NR^cSO₂N(R^c)₂, - (CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, -(CR^a₂)_nNR⁵C(O)R⁶, - (CR^a₂)_nOR⁵, -(CR^a₂)_nS(O)R^c, -(CR^a₂)_nS(O)₂R^c, and nitrogen containing 5-membered heterocyclic, heteroaryl or heterocyclenyl ring, wherein the alkyl and 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹ , Ci-C6alkyl, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-Cehydroxyalkyl, C₂-C6alkenyl, Ci- C₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, - SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, -W-(CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, or heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCi-C₆alkyl, Ci-C₆alkyl, -(CR^a₂)_zOR^c, -(CR^a₂)_zNHR⁸, -(CR^a₂)_zC(O)NR^cR^c, - (CR^a₂)_zCOOR¹⁰, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃- C₈cycloalkyl, -(CR^a₂)_zcyclenyl, and -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, -(CR^a₂)_zCOOR¹⁰, d- Cealkoxy, Ci-C6alkyl, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-Cehydroxyalkyl, C₂- C₆alkenyl, Ci-C₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C6)alkylamino;

R³ is selected from the group consisting of H, -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, - (CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸, -(CR^a₂)_qNR^cC(O)R⁸, -T-Ci-C₆alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T- heterocyclic, -T-C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl can be optionally substituted with halo, SH, OR^c, haloCrC₆alkyl, haloCi-C₆alkoxy, -(CR^a₂)_zCN, Ci-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, - (CR^a₂)_zC(O)OR¹¹ , -(CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, - (CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, - (CR^a₂)_zheterocyclic,

-(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR^cR⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, heterocyclic, heterocyclenyl and cyclenyl can further be substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹⁰, Ci-C₆alkoxy, C C₆alkoxyCi-C₆alkyl, CrC₆alkyl, C₂-C₆alkenyl, C Cehaloalkyl, Ci-C₆haloalkoxy, Ci-C₆hydroxyalkyl, CrC₆alkyl-C(=O)O-, Ci-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d- C₆alkylsulfonyl, Ci-C₆alkylannino or di(Ci-C₆)alkylannino;

R⁴ is selected from the group consisting of d-Cealkyl_, -(CR^a2)_maryl, - (CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)mC₃-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyl, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR^{1 1} , Ci-C₆alkoxy, CrC₆alkyl, C₃-C₆cycloalkyl, haloC₂-C6alkenyl, C₂-C6alkenyl, C₂-C6alkenoxy, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-C₆hydroxyalkyl, C_rC₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci -C6)alkylamino;

R⁵ is independently selected from the group consisting of H, CrC₆alkyl, -C₀- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- Cealkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C3alkenyl, C3-C6cycloalkyl, d-Csalkoxy, OH, halo, NH₂, Ci-C3alkylamino, Ci-Csdialkylamino or COOR^{1 1} ;

R⁶ is independently selected from the group consisting of H, Ci-C6alkyl, -Co- C6alkyl-C3-C8cycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, and -Co- Cealkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C₃alkenyl, C₃-C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C3alkylamino, Ci-Csdialkylamino or COOR^{1 1} ;

R⁷ is selected from the group consisting of H, Ci-C6alkyl, C₂-C6alkenyl, C3- Cscycloalkyl, aryl, heteroaryl, heterocyclic, wherein the alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, Ci- Cehaloalkyl, Ci-Cehaloalkoxy, C₂-C6alkenyl, C₂-C6alkynyl, Ci-C6alkyl, -Co-C6alkyl- Cs-Cscycloalkyl, -Co-C6alkyl-heteroaryl, -Co-C6alkyl-aryl, -Co-C6alkylheterocyclic, - C₀-C₆alkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNHR⁵, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)_zSO₂NR⁵R⁶, -(CR^a₂)_zC(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)_zNR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, and - (CR^a₂)_zS(O)₂R^c;

R⁸ is independently selected from the group consisting of H, -(CR^a₂)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a₂)_sC3-C₇cycloalkyl, and Ci-C6alkyl, wherein the heteroaryl, aryl, heterocyclic, heterocydenyl, cydenyl, cydoalkyi, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , Ci-C₆alkoxy, CrC₆alkyl, C₂-C₆alkenyl, C C₆haloalkyl, Ci-C₆haloalkoxy, Ci-C₆hydroxyalkyl, CrC₆alkyl-C(=O)O-, Ci-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d- C₆alkylsulfonyl, Ci-C₆alkylannino or di(Ci-C₆)alkylannino;

R⁹ is independently selected from the group consisting of H, Ci-C6alkyl, Ci- Cehaloalkyl, Cs-Cscycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, cydoalkyi, aryl, heteroaryl, and heterocyclic can be optionally substituted with -C₀- C₆alkylOR^c, C₀-C₆alkylN(R^c)₂, COOR¹⁰, nitro, CN, C C₆alkyl, Ci-C₆haloalkyl, Ci- C₆haloalkoxy, CrC₆hydroxyalkyl, C₂-C₆alkenyl, Ci-C₆alkyl-C(=O)O-, CrC₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d- C₆alkylsulfonyl, heterocyclic, or C(O)NHR^c;

R¹⁰ is independently selected from the group consisting of d-Cealkyl, -(CR^C₂)_ZC3- Cscycloalkyl, -(CR^c₂)_z-heteroaryl, -(CR^c₂)_z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with C_rC₆alkyl, OH, halo, or haloC_rC₆alkyl;

R¹¹ is independently selected from the group consisting of H, Ci-C6alkyl, - (CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cydoalkyi and alkyl can be optionally substituted with Ci-C6alkyl, OH, halo, or haloCi-Cealkyl;

R¹⁷ is independently selected from the group consisting of H, halo, Ci-C6alkyl, - (CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with Ci-C6alkyl, OH, halo, or haloCi-Cealkyl;

R^a is independently H , OR^c, NH₂, halo, d-Cealkyl, or C2-C6alkenyl, said alkyl or alkenyl is optionally substituted with OH, Ci-C₄alkoxy, NH₂, halo, haloCi-C₄alkyl, C3-C6cycloalkyl, or C2-C₄alkenyl;

R^c is independently H or d-Csalkyl optionally substituted with C2-C3alkenyl, C3- C6cycloalkyl, Ci-C3alkoxy, OH, halo, NH₂, Ci-C3alkylamino, or CrCsdialkylamino;

T is independently C₂-C₃alkenyl, -(CR^a₂)_q-_, -C(=CH₂)-, -(CR^a₂)_q-C(=CH₂)-, -C(=CH₂)-(CR^a₂)_q-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^C-;

U is H, COOR¹¹ , OH, heteroaryl or heterocyclic; n is independently 0, 1 , 2 or 3;

m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2 or 3; or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3, wherein

R¹ is selected from the group consisting of COOR¹¹ , -NHR^C, -NR^cSO₂R^c, - SO₂NR^cR^c, -C(O)R^c, -CONR^cR^c, -CONR^cOR^c, -OR^c, and nitrogen containing 5- membered heterocyclenyl or heteroaryl ring, wherein the 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹ , C_rC₆alkyl, Ci-C6haloalkyl, Ci-Cehaloalkoxy, Ci-C6hydroxyalkyl, C₂-C6alkenyl, Ci-C6alkyl- C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c Ci-C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, W-(CR^aR⁹)R⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, and heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCi-C₆alkyl, d-C₆alkyl, -(CR^a₂)OR^c, and -(CR^a₂)C(O)NR^cR^c, wherein the alkyl of R¹² can be optionally substituted with OH, CN, halo, haloCrC₆alkyl, or CON(R^c)₂;

R³ is selected from the group consisting of -NR^CR⁸, -OR⁸, -SR⁸, -C(O)R⁸, -S(O)R⁸, - S(O)₂R⁸, -CONR^cR⁸, -NR^cC(O)R⁸, -T- Ci-C₆alkyl, C₂-C₆alkenyl, -T-aryl, -T- heteroaryl, -T-heterocyclic, -T-C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl, wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl can be optionally substituted with halo, OR^c, halod-Cealkyl, halod- C₆alkoxy, -(CR^a₂)_zCN, Ci-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR¹¹ , - (CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, - (CR^a₂)_zSO₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C₆alkenyl;

R⁴ is selected from the group consisting of -(CR^a₂)aryl, -(CR^a₂)heteroaryl, - (CR^a₂)heterocyclic, -(CR^a₂)C₃-C₈cycloalkyl, -(CR^a₂)cyclenyl, and - (CR^a₂)heterocyclenyl, wherein the aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , Ci-C₆alkoxy, Ci-C₆alkyl, C₃-C₆cycloalkyl, haloC₂-C₆alkenyl, C₂- Cealkenyl, C₂-C6alkenoxy, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-C6hydroxyalkyl, Ci- C₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, - SO₂NR^cR^c, -NR^cSO₂R^c, Ci-C₆alkylsulfonyl, Ci-C₆alkylamino or di(C

C6)alkylamino;

R⁷ is selected from the group consisting of CrC₆alkyl, C₃-C₈cycloalkyl, heteroaryl, aryl, and heterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl or heterocyclic can be optionally substituted with halo, nitro, CN, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, Ci-C₆alkyl, or -(CR^a₂)_zOR^c;

R⁸ is independently selected from the group consisting of -(CR^a2)-heteroaryl, - (CR^a₂)-aryl, -(CR^a₂)-heterocyclic, -(CR^a₂)-heterocyclenyl, -(CR^a₂)cyclenyl, - (CR^a₂)cycloalkyl, and d-Cealkyl, wherein the heteroaryl, aryl, heterocyclic, heterocydenyl, cydenyl, cydoalkyi, and alkyl can be optionally substituted with OH, Ci-C6alkoxy, d-Cealkyl, Ci-Cehaloalkyl, Ci-Cehaloalkoxy, d-Cehydroxyalkyl, or halo group;

R⁹ is H, CrC₃alkyl, Ci-C₃haloalkyl, C₃-C cycloalkyl, wherein the alkyl or cydoalkyi can be optionally substituted with OR^c, N(R^C)₂, heterocyclic, C(O)NHCH₂CH₂OH, C(O)NH₂, or C(O)NHCi-C₃alkyl;

R¹¹ is independently selected from the group consisting of H and CrC₆alkyl, wherein alkyl can be optionally substituted with OH or halo;

R¹⁷ is independently selected from the group consisting of H or halo;

R^a is independently H , OR^c, NH₂, halo, CrC₆alkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, Ci-C₄alkoxy, NH₂, F, CF₃, C₃-C6cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or Ci-C₃alkyl optionally substituted with C₂-C₃alkenyl, C₃- C6cycloalkyl, Ci-C₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or Ci-C₃dialkylamino;

T is independently -(CR^a₂)_q-, or -C(=CH₂)-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^C-;

U is H, COOR¹¹ , OH, heteroaryl or heterocyclic; q is independently 0 or 1 ; v is independently 1 or 2; and

z is independently 0, 1 or 2.

5. The compound of claim 3, wherein

R¹ is selected from the group consisting of COOR¹¹ , -NHR^C, -NR^cSO₂R^c, - SO₂NR^cR^c, -C(O)R^c, -CONR^cR^c, -CONR^cOR^c, -OR^c, and nitrogen containing 5- membered heterocyclenyl ring, wherein the 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹ , CrC₆alkyl, Ci- Cehaloalkyl, Ci-Cehaloalkoxy, Ci-Cehydroxyalkyl, C2-C6alkenyl, Ci-C6alkyl- C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, and -NR^c-(CR^aR⁹)R⁷, wherein the aryl, or heteroaryl is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCrC₆alkyl, d-C₆alkyl, -(CR^a₂)OR^c, wherein the alkyl of R¹² can be optionally substituted with OH, CN, halo, haloCi-Cealkyl, or CON(R^c)₂;

R³ is selected from the group consisting of -T-aryl, -T-heteroaryl, and -T- heterocyclic, wherein the heteroaryl, and heterocyclic can be optionally substituted with halo, OR^c, haloCi-C₆alkyl, haloCi-C₆alkoxy, -(CR^a₂)_zCN, CrC₆alkyl, C₂- C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR¹¹ , -(CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, - (CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, - (CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zSO₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU;

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C6alkenyl;

R⁴ is selected from the group consisting of -(CR^a₂)aryl, -(CR^a₂)C3-C6cycloalkyl, and -(CR^a₂)C3-C6cyclenyl, wherein the aryl, cycloalkyi, and cyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , C C₆alkoxy, Ci- C₆alkyl, C₃-C₆cycloalkyl, haloC₂-C₆alkenyl, C₂-C₆alkenyl, C₂-C₆alkenoxy, C

Cehaloalkyl, Ci-C₆haloalkoxy, Ci-C₆hydroxyalkyl, CrC₆alkyl-C(=O)O-, Ci-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c d- Cealkylsulfonyl, Ci-C6alkylamino or di(Ci-C6)alkylamino;

R⁷ is C3-C6cycloalkyl optionally substituted with halo, nitro, CN, Ci-Cehaloalkyl, Ci- C₆haloalkoxy, CrC₆alkyl, or -(CR^a₂)_zOR^c;

R⁹ is Ci-C₃alkyl;

R¹⁷ is H;

and all other substituents are as defined in claim 3.

6. The compound of any one of claims 3 to 4, wherein R¹ is COOH or a nitrogen containing 5-membered heteroaryl, heterocyclyl or heterocyclenyl ring selected from the group consisting of tetrazolyl, oxadiazolyl,

oxadiazolone, dihydro-oxadiazolyl, triazolyl, dihydro-triazolyl, dihydro-triazolone, pyrrolidinyl, and imidazolyl, wherein the nitrogen containing 5-membered ring can be optionally substituted with halo, d-C₆alkyl, haloCrC₆alkyl, NH₂, OR^c, SR^C, COOH, or -NR^cSO₂R^c.

7. The compound of any one of claims 3 to 4, wherein

CH₃ or H.

8. The compound of any one of claims 3 to 5, wherein

9. The compound of any one of claims 3 and 7 to 8, wherein R² is

R^e is H, -(CR^a₂)_zC(O)OR¹⁰, halo, haloCi-C₃alkyl or C_rC₃alkyl;

K and L are independently CR¹⁴ or N;

R¹⁴ is independently H, halo, CN, haloC C₆alkyl, C C₆alkyl, -(CR^a₂)_zC(O)NR^cR^c, - (CR^a₂)_zOR^c, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃- C₈cycloalkyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cydoalkyi, cyclenyl or heterocyclenyl can be optionally substituted with OH, CN, halo, haloCi-C₃alkyl, or CON(R^c)₂; and

h is 0 or 1 .

10. The compound of any one of claims 3-4 and 6-9, wherein R³ is -T- heterocyclic optionally substituted with halo, OR^c, haloCi-Cealkyl, haloCi-Cealkoxy, CN, Ci-C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR^{1 1}, -(CR^a₂)_zC(O)R⁸, - (CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, - (CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zSO₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU;

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cydoalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C₆alkenyl.

X is NR¹⁹ CR¹⁶2, S, or O;

R¹⁵ is independently selected from the group consisting of phenyl, 5 or 6-membered heterocyclic or heteroaryl, haloCi-Cealkyl, haloC2-C6alkenyl, halo, haloCi-Cealkoxy, Ci-C₆alkoxy, Ci-C₆alkoxyCi-C₆alkyl, d-C₆alkyl, C₂-C₆alkenyl, C₃-C₆cycloalkyl, amino, CN, OH, and SH;

two adjacent R¹⁵ form a fused C3-C₇cycloalkyl or heterocyclic ring; two non- adjacent R¹⁵ form a d-Csalkylene;

or two Re attached to the same carbon form a C₃-C₇cycloalkyl or heterocyclic ring, wherein the phenyl, heteroaryl, cycloalkyl or heterocyclic can be optionally substituted with R¹³ selected from the group consisting of haloCi-Cealkyl, haloC2- Cealkenyl, halo, haloCi-Cealkoxy, d-Cealkoxy, Ci-CealkoxyCi-CealkyI, Ci-C6alkyl, C₂-C₆alkenyl, amino, CN, OH, or SH;

R¹⁶ is independently selected from the group consisting of H, haloCi-Cealkyl, haloC2-C6alkenyl, halo, haloCi-Cealkoxy, Ci-Cealkoxy, Ci-CealkoxyCi-CealkyI, Ci- Cealkyl, C2-C6alkenyl, amino, CN, OH, and SH;

R¹⁹ is independently selected from the group consisting of H, haloCi-C₆alkyl, haloC2-C6alkenyl, Ci-C6alkoxyC C6alkyl, Ci-C6alkyl, and C2-C6alkenyl;

f is 0, 1 or 2;

g is 0, 1 or 2;

j is independently 0, 1 , 2, 3, 4, 5, 6, 7, or 8.

12. The compound of any one of claims 3, 7 to 9, wherein R³ is

(R¹⁵)j Ring B is a fused C3-C₇cycloalkyl;

X is CR¹⁶2, S, or O;

R¹³ , R¹⁵ and R¹⁶are independently haloCi-C₆alkyl, haloC₂-C₆alkenyl, halo, halod-

Cealkoxy, Ci-C6alkoxy, Ci-C6alkoxyC C6alkyl, Ci-C6alkyl, C3-C6cycloalkyl, C₂-

Cealkenyl, amino, CN, OH, or SH;

r is independently 0, 1 , 2, 3, 4, 5, 6, 7 or 8; and

j is independently 0, 1 , 2, 3, or 4.

13. The compound of any one of claims 3, 7 to 9,

wherein R³ is R¹⁸

X is CH₂ or O;

R¹⁸ and R²⁰ are independently H, haloCi-Cealkyl, haloC2-C6alkenyl, halo, halod- Cealkoxy, Ci-C6alkoxy, Ci-C6alkoxyC C6alkyl, Ci-C6alkyl, C3-C6cycloalkyl, C₂- Cealkenyl, amino, CN, OH, or SH; and

f is 0, 1 or 2.

14. The compound of any one of claims 3 to 13, wherein R⁴ is -CH₂-Y or - CH₂(CH₃)-Y, wherein Y is phenyl or cyclohexyl optionally substituted with haloCi- C₃alkyl, haloC₂-C₃alkenyl, halo, C₃-C₄cycloalkyl, haloC C₃alkoxy, C C₃alkoxy, C₂- C₃alkenoxy, Ci-C₃alkyl, C₂-C₃alkenyl, amino, CN, OH, or SH.

15. The compound of claim 1 , wherein

R¹ is COOH, C(O)OR^c, C(O)NR^cR^c, C(O)NR^cSO₂R^c , C(O)NR^cSO₂NR^cR^c,

NR^uSO₂R^t;, or

wherein R^d is methyl or H.

R_j is H or methyl,

R^h is independently halo, NR^CR^C, hydroxyCi-C₄alkyl, hydroxyCi-C₄alkoxy, -OC1- C₃alkylOCrC₃alkyl, Ci-C₄alkyl or C C₄alkoxy;

a is 0, 1 or 2;

R³ is

X is O, S, NR¹⁶ CR¹⁶2, or SO₂;

R¹⁵ is independently selected from the group consisting of phenyl, 5 or 6-membered heteroaryl, heterocyclic, haloCi-C₃alkyl, halo, haloCi-C₃alkoxyCo-C₃alkyl, Ci- C₃alkoxy, Ci-C₃alkoxyCi-C₃alkyl, Ci-C₃alkoxyCrC₃alkoxy, Ci-C₃alkoxyC₃- Cscycloalkyl, CrC₆alkyl, C₃-C₆cycloalkyl, C(O)R^f, C(O)NR^c₂, and hydroxyCi- C₃alkyl;

two non-adjacent R¹⁵ form a C₂-C₃ alkylene bridge;

two adjacent R¹⁵ form a fused C₃-C6cycloalkyl or 4, 5 or 6- membered heterocyclic ring;

or two R¹⁵ attached to the same carbon form =O, a C₃-C6cycloalkyl or 5 or 6- membered heterocyclic ring, wherein the phenyl, heteroaryl, cycloalkyi or heterocyclic can be optionally substituted with halo, or d-Csalkyl;

R¹⁶ is independently selected from the group consisting of H, haloCi-C₃alkyl, halo, haloCrC3alkoxyCo-C3alkyl, Ci-C3alkoxy, Ci-C3alkoxyCi-C3alkyl, Ci-C6alkyl, C3-

Cecycloalkyl, C(O)R^f, C(O)NR^c₂, S(O)₂R^c C(O)OR¹⁰ and hydroxyC C₃alkyl;

R^c is independently H or Ci-C3alkyl optionally substituted with halo or Ci-C3alkoxy;

R¹⁰ is independently Ci-C₃alkyl optionally substituted with halo;

R^f is independently H, Ci-C3alkyl or C3-C₄cycloalkyl, wherein the alkyl or cycloalkyi is optionally substituted with halo, Ci-C3alkoxy, or 4-6 membered heterocyclic; f is 0, 1 or 2;

g is 0, or 1 ;

j is independently 0, 1 , or 2; or R³ is NR⁸R^C, T-CrC₆alkyl, -T-aryl, -T-heteroaryl, T-heterocyclic, T-C₃- C_/cycloalkyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, and cycloalkyi can be optionally substituted with halo, OR^c, SR^C, SO₂R^c , haloCi-C₃alkyl, haloCrC₃alkoxy, or Ci-C3alkyl;

R⁸ is H, Ci-C6alkyl, aryld-Cealkyl, or heterocyclic, wherein the alkyl, aryl or heterocyclic is optionally substituted with d-dalkoxy, or haloCi-dalkyl;

T is independently -(CR^a₂)-_, -C(=CH₂)-, or -C(O)-;

R^a is independently H , OR^c, halo, or Ci-C3alkyl, said alkyl is optionally substituted with OH, Ci-C3alkoxy, halo, or haloCi-CsalkyI;

/

R^b and R^s are independently H, halo, haloCi-CsalkyI or Ci-Csalkyl;

R⁹ is H, C(O)NHR^c, or methyl;

i and I are independently 0, 1 , 2, 3, 4 or 5; and

e is 0, 1 or 2.

16. The compound of claim 2, wherein

COOH, C(O)NR^cSO₂R^c , C(O)NR^cSO₂NR^cR^c or

wherein R^d is methyl or H.

R is independently halo, hydroxyCi-C₄alkyl, hydroxyCi-C₄alkoxy,

C₃alkylOCrC₃alkyl, C C₄alkyl or C_rC₄alkoxy;

a is 0, 1 or 2.

R³ is

X is NR¹⁶ CR¹⁶2, or SO₂;

R¹⁵ is independently selected from the group consisting of phenyl, 5 or 6-membered heteroaryl, heterocyclic, haloCi-Csalkyl, halo, haloCi-CsalkoxyCo-CsalkyI, Ci- C₃alkoxy, Ci-C₃alkoxyCi-C₃alkyl, Ci-C₆alkyl, C₃-C₆cycloalkyl, C(O)R^f, C(O)NR^c₂, and hydroxyCi-C3alkyl;

two non-adjacent R¹⁵ form a C₂-C₃ alkylene bridge;

two adjacent R¹⁵ form a fused C3-C6cycloalkyl or 5 or 6- membered heterocyclic ring; or two R¹⁵ attached to the same carbon form =O, a C3-C6cycloalkyl or 5 or 6- membered heterocyclic ring,

wherein the phenyl, heteroaryl, cycloalkyi or heterocyclic can be optionally substituted with halo, or Ci-dalkyl;

R¹⁶ is independently selected from the group consisting of haloCi-Csalkyl, halo, haloCi-CsalkoxyCo-CsalkyI, d-dalkoxy, Ci-C3alkoxyCi-C3alkyl, d-Cealkyl, d-

Cecycloalkyl, C(O)R^f, C(O)NR^c₂, and hydroxyC_rC₃alkyl;

R^c is independently H or Ci-C3alkyl optionally substituted with halo;

R^f is independently H, Ci-C3alkyl or C3-C₄cycloalkyl;

f is 0, 1 or 2;

g is 0, or 1 ;

j is independently 0, 1 , or 2; or R³ is NR⁸R^C, T-CrC₆alkyl, -T-aryl, -T-heteroaryl, T-heterocyclic, T-C₃- C_/cycloalkyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, and cycloalkyi can be optionally substituted with halo, OR^c, SO2R^c , halod-dalkyl, halod-dalkoxy, or Ci-C₃alkyl;

R⁸ is H, d-Cealkyl, arylCi-dalkyl, or heterocyclic, wherein the alkyl, aryl or heterocyclic is optionally substituted with d-dalkoxy, or halod-Csalkyl;

T is independently -(CR^a₂)-, -C(=CH₂)-, or -C(O)-;

R^a is independently H , OR^c, halo, or Ci-Csalkyl, said alkyl is optionally substituted with OH, d-dalkoxy, halo, or haloCi-Csalkyl;

/

R^b and R^s are independently H, halo, haloCi-Csalkyl or Ci-dalkyl;

R⁹ is H, C(O)NHR^c, or methyl;

i and I are independently 0, 1 , 2, 3, 4 or 5; and

e is 0, 1 or 2.

17. The compound of claim 2 or 16, wherein

I

R² is R^e and R^e is halo.

18. The compound of claim 2, 16 or 17, wherein

R^b is independently H, halo, halod-Csalkyl or Ci-C3alkyl;

R⁹ is H, C(O)NHR^c, or methyl;

R^c is independently H or CrC₃alkyl optionally substituted with halo;

I is 0, 1 , 2, 3, 4 or 5;

e is 0, 1 or 2.

19. The compound of claim 3 selected from the group consisting of:

(R)-4-((1 -cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4- (trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

4-{[(1 R)-1 -cyclobutylethyl]amino}-2-[4-(1 -methylethyl)pyridin-2-yl]-3-[4- (trifluoromethyl)benzyl]-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

4-{[(1 R)-1 -cyclobutylethyl]amino}-2-(3-methylphenyl)-3-[4-(trifluoromethyl)benzyl]- 3H-imidazo[4,5-c]pyridine-6-carboxylic acid; 4- {[(1 R)-1 -cyclobutylethyl]amino}-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2-[4-(1 - methylethyl)pyridin-2-yl]-3H-imidazo[4,5-c]pyndine-6-carboxylic acid;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

5- {4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,3,4-oxadiazol-2(3H)-one; 3-{3-[(trans-4-methylcyclohexyl)methyl]-4-(3-methylphenyl)-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(3-chlorophenyl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 5-{4-(3-chlorophenyl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,3,4-oxadiazol-2(3H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-((4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl)-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(octahydro-4H- 1 ,4-benzoxazin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 5-{4-(5-chloropyridin-3-yl)-2-(hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl)-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadiazol- 2(3H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(1 -methoxy-1 -methylethyl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

5-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadiazol-2(3H)-one; 3-{4-(5-chloropyridin-3-yl)-2-((4aS,7aS)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(octahydro-4H- 1 ,4-benzoxazin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 5-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(octahydro-4H- 1 ,4-benzoxazin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,3,4-oxadiazol-2(3H)-one; 5-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(1 -methoxy-1 -methylethyl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadiazol- 2(3H)-one;

5-{4-(5-chloropyridin-3-yl)-2-((4aS,7aS)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4- oxadiazol-2(3H)-one;

5-{4-(5-chloropyridin-3-yl)-2-((4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4- oxadiazol-2(3H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2S)-2- (trifluoromethyl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

5-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(octahydro-4H-

1 ,4-benzoxazin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,3,4-oxadiazol-2(3H)-one;

5-{4-(5-chloropyridin-3-yl)-2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadiazol-2(3H)-one;

5-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2S)-2-

(trifluoromethyl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadia one;

4- (5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- methylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(3S,5S)-3,5-dimethylmorpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(octahydro-1 H- cyclopenta[b]pyridin-1 -yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-[6-

(trifluoromethyl)-2-azabicyclo[3.^

oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(3-ethylnnorpholin-4-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(2-oxa-5- azabicyclo[4.1 .0]hept-5-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyridin-3-yl)-2-(2,5-dimethylnnorpholin-4-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(3-methyl-1 ,4- oxazepan-4-yl)-3H-imidazo[4,5-c]pyndin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2-[2-(1 - methylethyl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)^ one;

3- {4-(5-chloropyridin-3-yl)-2-[(2R,5R)-2,5-dimethylpyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

4- (5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2S)-2- (trifluoromethyl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3-{4-(5-chloropyridin-3-yl)-2-[3-(2-fluorophenyl)morpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[2-(1 -methoxyethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[3-(2-fluorophenyl)morpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(2,3-dimethylpyrrolidin-1 -yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(2-cyclopropylpyrrolidin-1 -yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{2-(2-tert-butylpyrrolidin-1 -yl)-4-(5-chloropyridin-3-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{2-(5-azaspiro[3.4]oct-5-yl)-4-(5-chloropyridin-3-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[2-(1 ,1 -dimethylpropyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(4-methyl- 1 ,2,5-oxadiazol-3-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2R)-2- methylpiperidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; and

3-{4-(5-chloropyridin-3-yl)-2-[(2R,4R)-4-hydroxy-2-methylpyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; or a stereoisomer thereof;

or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt of the stereoisomer thereof.

20. The compound of claim 2 selected from the group consisting of:

3- {4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(4-methyl-

1 ,2,5-oxadiazol-3-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

4- (5-chloropyridin-3-yl)-2-((4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(trans-2-methyl-5- phenylmorpholin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,4R)-4-methoxy-2-methylpyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(hexahydro-4H-furo[3,4-b][1 ,4]oxazin-4-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N,N-dimethyl-D- prolinamide; 1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-N-methyl-D- prolinamide;

3-{4-(5-chloropyridin-3-yl)-2-[2-(3-ethyl-5-nnethylisoxazol-4-yl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-{2-[(1 - methylethoxy)methyl]pyrrolidin-1 -yl}-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol- 5(4H)-one ;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-{2- [(trifluoromethoxy)methyl]pyrrol^ ,2,4- oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2R)-2- methylpyrrolidin-1 -yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(methoxymethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(difluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(trans-2,3-dimethylmorpholin-4-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(7-oxa-1 - azaspiro[4.4]non-1 -yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(8-oxa-1 - azaspiro[4.5]dec-1 -yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-2-(hexahydro-2H-pyrano[4,3-b]pyridin-1 (5H)-yl)-3-[(tra^

4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(1 H-1 ,2,3- triazol-5-yl)pyrrolidin-1 -yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(1 -methyl-1 H- 1 ,2,4-triazol-3-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(1 -methyl-1 H- 1 ,2,4-triazol-5-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2S)-2-(1 ,3- thiazol-2-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2-[2-(3- methylisoxazol-5-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[2-(3,5-dimethylisoxazol-4-yl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(3-methyl- 1 ,2,4-oxadiazol-5-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

1 - [4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-D-prolinamide; (5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]-1 ,5-dimethylpiperazin-

2- one;

3- {4-(5-chloropyridin-3-yl)-2-[(2R)-5-methoxy-2-methylpiperidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(3-methyl-1 ,1 - dioxidothiomorpholin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(2-methoxy-7-azabicyclo[2.2.1 ]hept-7-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-methoxy-2-(1 -methylethyl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-hydroxy-2-(1 -methylethyl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one; 3-{4-(5-chloropyndin-3-yl)-2-[(2S,4R)-2-(fluoromethyl)-4-methoxypyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,4R)-2-(fluoromethyl)-4-methoxypyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{2-[(2R)-4-acetyl-2-methylpiperazin-1 -yl]-4-(5-chloropyridin-3-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2R)-4-(cyclopropylcarbonyl)-2-nnethylpiperazin-1 -yl]- 3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3- {2-[(2R,6R)-4-acetyl-2,6-dimethylpiperazin-^

4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-4-(cyclopropylcarbonyl)-2,6- dimethylpiperazin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5- c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[cyclopentyl(ethoxy)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

5- {4-(5-chloropyridin-3-yl)-2-[cyclopentyl(ethoxy)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4-oxadiazol-2(3H)-one; 3-(4-(5-chloropyridin-3-yl)-2-(1 -ethoxyethyl)-3-((trans-4-methylcyclohexyl)methyl)- 3H-imidazo[4,5-c]pyndin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-2-(1 -ethoxypropyl)-3-((trans-4-methylcyclohexyl)methyl)-

3H-imidazo[4,5-c]pyndin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-3-((trans-4-methylcyclohexyl)methyl)-2-(1 -(2,2,2- trifluoroethoxy)propyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-3-((trans-4-methylcyclohexyl)nnethyl)-2-(1 - propoxypropyl)-3H-imidazo[4,5-c]pyndin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[ethoxy(phenyl)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2,4-difluorophenyl)(hydroxy)nnethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2-fluorophenyl)(hydroxy)nnethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(1 -hydroxy-2-methoxy-1 -phenylethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-2-(ethoxy(pyridin-2-yl)methyl)-3-((trans-4- methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-2-(ethoxy(pyridin-3-yl)methyl)-3-((trans-4- methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2-fluorophenyl)carbonyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[1 -fluoro-1 -(2-fluorophenyl)ethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[1 -(2,4-difluorophenyl)-1 -fluoroethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methy^

3H-imidazo[4,5-c]pyndin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(2-methoxy-1 -phenylethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;and

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(1 - methylidenebutyl)-3H-innidazo[4,5-c]pyndin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

or a stereoisomer thereof;

or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt of the stereoisomer thereof.

21 .The compound of claim 1 selected from the group consisting of:

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[methyl(2,2,2- trifluoroethyl)amino]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-2-((trans-4-methoxytetrahydrofuran-3-yl)(methyl)amino)- 3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol- 5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(1 -methyl-1 H-

1 .2.3- triazol-4-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-N-methyl-L- prolinamide;

3-{4-(5-chloropyridin-3-yl)-2-[(2-fluorophenyl)annino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[2-(1 -ethyl-1 H-pyrazol-5-yl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(1 -methyl-1 H- pyrazol-4-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(5-methyl-

1 .2.4- oxadiazol-3-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(3-methyl- 1 ,2,4-oxadiazol-5-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(6-oxa-1 - azaspiro[3.3]hept-1 -yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2-methoxy-2-methylpropyl)(methyl)amino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[2-(2-methyl-1 ,3- thiazol-4-yl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

3-{4-(5-chloropyndin-3-yl)-2-[(2-methoxyethyl)(methyl)amino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[ethyl(2-methoxyethyl)annino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N,N-dimethyl-L- prolinamide; 3-{4-(5-chloropyridin-3-yl)-2-[(2-methoxyethyl)(propyl)annino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(1 -pyndin-2- ylethyl)amino]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-L-prolinamide;

3-{2-[(2S,5S)-2,5-bis(methoxymethyl)pyrrolidin-1 -yl]-4-(5-chloropyridin-3-yl)-3-

[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-

5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[cis-4-methoxy-2-methylpiperidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[trans-4-methoxy-2-methylpiperidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-2-[cis-4-methoxy-2-methylpiperidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; (4aS,7aS)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo- 4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-1 -methyloctahydro- 2H-cyclopenta[b]pyrazin-2-one;

4- [4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]-5-ethyl-1 - methylpiperazin-2-one;

3- {4-(5-chloropyridin-3-yl)-2-(hexahydro-2^

4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)- one;

benzyl (4aR,8aR)-1 -[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6- (5-0X0-4, 5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]octahydro- 6H-pyrido[3,4-b][1 ,4]oxazine-6-carboxylate;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(4aR,8aR)- octahydro-1 H-pyrido[3,4-b][1 ,4]oxazin-1 -yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one;

3-{2-[(4aR,8aR)-6-benzyloctahydro-1 H-pyrido[3,4-b][1 ,4]oxazin-1 -yl]-4-(5- chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6- yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(2-hydroxy-7-azabicyclo[2.2.1 ]hept-7-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(2-methoxy-7-azabicyclo[2.2.1 ]hept-7-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4S)-4-hydroxy-4-methyl-2-(1 - methylethyl)pyrrolidin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imi^

c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyndin-3-yl)-2-[(2S,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1 -yl]- 3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(3-hydroxyoctahydroquinolin-1 (2H)-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-methoxy-2-(1 - methoxycyclopropyl)pyrrolidin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H- imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,4R)-4-methoxy-2-(1 - methoxycyclopropyl)pyrrolidin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H- imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(3- methylthiomorpholin-4-yl)-3H-imidazo^

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-2-(difluoromethyl)-4-methoxypyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-ethoxy-2-(fluoromethyl)pyrrolidin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

(4aR,7aR)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo- 4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]-1 -ethyloctahydro- 2H-cyclopenta[b]pyrazin-2-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-(2-methoxyethoxy)-2-(1 - methylethyl)pyrrolidin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imi^

c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyndin-3-yl)-2-[(trans)-5,5-difluorohexahydrocyclopenta[b][1 ,4]oxazin- 4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-y^ 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(trans)-3- methylhexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3H-imidazo[4,5-c]pyridin-6-yl}- 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,3R)-3-ethyl-2-methylmorpholin-4-yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(trans)-6,6-difluorohexahydrocyclopenta[b][1 ,4]oxazin- 4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-y^ 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-pyndin-2- ylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(hexahydro-4H,5H-pyrano[4,3-b][1 ,4]oxazin-4-yl)-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(2- methylhexahydro-4H,5H-pyrano[4,3-b][1 ,4]oxazin-4-yl)-3H-imidazo[4,5-c]pyridin-6- yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(trans)-hexahydro-4H-furo[3,4-b][1 ,4]oxazin-4-yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(trans)-6-fluorohexahydrocyclopenta[b][1 ,4]oxazin- 4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-y^ 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(hexahydro-2H-cyclopenta[b][1 ,4]oxazepin-5(5aH)-yl)- 3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(2,2,3- tnmethylmorpholin-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(2- methyloctahydro-4H-1 ,4-benzoxazin-4-yl)-3H-innidazo[4,5-c]pyndin-6-yl]-1 ,2,4- oxadiazol-5(4H)-one; 3-{2-(benzylamino)-4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]- 3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2-methoxy-1 -methylethyl)amino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{2-[benzyl(methyl)annino]-4-(5-chloropyndin-3-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-(2- methylhexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl)-3H-imidazo[4,5-c]pyridin-6-yl]- 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(2R,3R)-2,3,6- tnmethylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2-methoxy-1 -methylethyl)(methyl)amino]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3- [4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(pyridin-2- ylamino)-3H-innidazo[4,5-c]pyndin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

4- (5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(pyridin-2-ylamino)- 3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3- {4-(5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2- [methyl(phenyl)amino]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

4- (5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2- [methyl(phenyl)amino]-3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(phenylamino)- 3H-imidazo[4,5-c]pyndin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl]-3-[(1 R or S)-1 -(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}- 1 ,2,4-oxadiazol-5(4H)-one;

3-(4-(5-chloropyridin-3-yl)-3-(1 -(trans-4-methylcyclohexyl)ethyl)-2-((R)-3- methylmorpholino)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one;

(5R)-4-[4-(5-chloropyridin-3-yl)-3-[1 -(trans-4-methylcyclohexyl)ethyl]-6-(5-oxo-4,5- dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]-1 ,5-dimethylpiperazin- 2-one; 3-{4-(5-chloropyndin-3-yl)-2-[(2S,4R)-2-(fluoromethyl)-4-methoxypyrrolidin-1 -yl]-3- [1 -(trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidin-1 -yl]-3-[1 - (trans-4-methylcyclohexyl)ethyl]-3H-innidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-2-[(2R,4R)-4-methoxy-2-methylpyrrolidin-1 -yl]-3-[1 -(tran

4- methylcyclohexyl)ethyl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-2-[(2R,4R)-4-hydroxy-2-methylpyrrolidin-1 -yl]-3-[1 -(trans-

4- methylcyclohexyl)ethyl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-2,6-dim^

3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

ethyl (3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5- oxo-4, 5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-innidazo[4,5-c]pyndin-2-yl]-3,5- dimethylpiperazine-1 -carboxylate;

(3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo-

4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-3,5- dimethylpiperazine-1 -carboxannide;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-2,6-dimethyl-4-propanoylpiperazin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyndin-3-yl)-2-[(2R,6R)-4-(cyclobutylcarbonyl)-2,6-dimethylpiperazin-

1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,^ oxadiazol-5(4H)-one;

3-{2-[(2R,6R)-4-butanoyl-2,6-dimethylpiperazin-1 -yl]-4-(5-chloropyridin-3-yl)-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

methyl (3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6- (5-0X0-4, 5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-3,5- dimethylpiperazine-1 -carboxylate; 1 -methylethyl (3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4- methylcyclohexyl)nnethyl]-6-(5-oxo-4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H- imidazo[4,5-c]pyridin-2-yl]-3,5-dinnethylpiperazine-1 -carboxylate;

(3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo- 4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-3,5-dimethyl-N- propylpiperazine-1 -carboxamide;

(3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo- 4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-3,5-dimethyl-N-(1 - methylethyl)piperazine-1 -carboxamide;

3-{2-(4-acetyl-2,3-dimethylpiperazin-1 -yl)-4-(5-chloropyridin-3-yl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[4-(cyclopropylcarbonyl)-2,3-dimethylpiperazin-1 -yl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-2,6-dimethyl-4-(2-methylpropanoyl)piperaz

1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-y^

oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-4-(cyclopropylcarbonyl)octahydro-1 H- cyclopenta[b]pyrazin-1 -yl]-3-[(trans-4-methylcy^

c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{2-[(4aR,7aR)-4-acetyloctahydro-1 H-cyclopenta[b]pyrazin-1 -yl]-4-(5-chloropyridin-

3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-y^

oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-4-(difluoroacetyl)octahydro-1 H- cyclopenta[b]pyrazin-1 -yl]-3-[(trans-4-methylcy^

c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-4-(cyclobutylcarbonyl)octahydro-1 H- cyclopenta[b]pyrazin-1 -yl]-3-[(trans-4-methylcy^

c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

(3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo- 4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N,N,3,5- tetramethylpiperazine-1 -carboxamide; (3R,5R)-4-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-6-(5-oxo-

4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H-imidazo[4,5-c]pyridin-2-yl]-N-ethyl-N,3,5- trimethylpiperazine-1 -carboxamide;

3-{4-(5-chloropyridin-3-yl)-2-{(2R,6R)-4-[(1 -fluorocyclopropyl)carbonyl]-2,6- dimethylpiperazin-1 -yl}-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5- c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-{(2R,6R)-4-[(2,2-difluorocyclopropyl)carbonyl]-2,6- dimethylpiperazin-1 -yl}-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5- c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-4-(difluoroacetyl)-2,6-dimethylpiperazin-1 ^ 3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-{(2R_>6R)-2_>6-dimethyl-4-[(3-methyloxetan-3- yl)carbonyl]piperazin-1 -yl}-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5 c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

S^-iS-chloropyridin-S-yl^- R^R^^-dimethyl^- I - methylcyclopropyl)carbonyl]piperazin-1 -yl}-3-[(trans-4-methylcyclohexyl)methyl]-3H- imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-2,6-dimethyl-4-(oxetan-3- ylcarbonyl)piperazin-1 -yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5- c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(2R,6R)-4-(methoxyacetyl)-2,6-dimethylpiperazin-1 -yl]- 3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(1 -ethoxy-2-hydroxyethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(1 -ethoxy-2-nnethoxyethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[cyclopropyl(ethoxy)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[ethoxy(tetrahydro-2H-pyran-4-yl)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[cyclopropyl(2-methoxyethoxy)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-(4-(5-chloropyridin-3-yl)-2-(ethoxy(pyridin-2-yl)methyl)-3-((trans-4- methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[ethoxy(1 ,3-thiazol-4-yl)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[ethoxy(1 -methyl-1 H-pyrazol-3-yl)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[ethoxy(1 ,3-thiazol-4-yl)methyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[pyndin-2-yl(2,2,2- trifluoroethoxy)methyl]-3H-innidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(1 R or S)-1 -fluoro-1 -(3-fluoropyridin-2-yl)ethyl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(1 R or S)-1 -fluoro-1 -(3-fluoropyridin-4-yl)ethyl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(1 R or S)-1 -fluoro-1 -(3-methylpyridin-2-yl)ethyl]-3- [(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(1 R or S)-1 -fluoro-1 -(pyridin-2-yl)ethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(1 -fluoro-2-methoxy-1 -methylethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[1 -(3-fluoropyridin-2-yl)ethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[1 -(methoxymethyl)butyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-(1 -methylethenyl)- 3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-(2-methoxy-1 -methylethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-(2-ethoxy-1 -methylethyl)-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[1 -methyl-2-(1 - methylethoxy)ethyl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[1 -(methoxynnethyl)propyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[2-methoxy-1 -(methoxymethyl)ethyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[1 -(methoxymethyl)-2-methylpropyl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2-[4-(1 - methylethyl)pyridin-2-yl]-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{7-bromo-4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{7-chloro-4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-7-fluoro-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl]-7-methoxy-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}- 1 ,2,4-oxadiazol-5(4H)-one;

3- {4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)- yl]-7-methyl-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-

1 ,2,4-oxadiazol-5(4H)-one;

4- (5-chloropyridin-3-yl)-7-(dinnethylannino)-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyridine-6-carboxylic acid;

3- {4-(5-chloropyridin-3-yl)-2-[(2R or S)-1 -methoxypropan-2-yl]-3-[(1 R or S)-1 -(trans-

4- methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-

3- [(trans-4-methylcyclohexyl)methyl]-N-(methylsulfonyl)-3H-imidazo[4,5-c]pyridi 6-carboxamide;

4- (5-chloropyridin-3-yl)-N-(dinnethylsulfannoyl)-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)methyl]- 3H-imidazo[4,5-c]pyridine-6-carboxannide;

4-(5-chloropyridin-3-yl)-N-methyl-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxamide;

4-(5-chloropyridin-3-yl)-N,N-dimethyl-3-[(trans-4-methylcyclohexyl)methyl]-^

3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxamide;

N-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}methanesulfonamide;

4- (5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-6-(1 H-tetrazol-5-yl)-2- [(2S)-2-(trifluoromethyl)pyrrolidin-1 -yl]-3H-imidazo[4,5-c]pyridine;

5- {4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-2-methyl-1 ,2-dihydro-3H- 1 ,2,4-triazol-3-one;

5-{4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1 -yl]-3-[(trans-4- methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-2,4-dihydro-3H-1 ,2,4- triazol-3-one;

4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-

3-[(trans-4-methylcyclohexyl)methyl]-6-(1 H-tetrazol-5-yl)-3H-imidazo[4,5-c]pyridine; methyl 4-(5-chloropyridin-3-yl)-3-[(trans-4-nnethylcyclohexyl)nnethyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxylate;

ethyl 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)nnethyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxylate;

3-{4-(5-chloropyridin-3-yl)-2-[(S or R)-cyclopropyl(ethoxy)methyl]-3-[(1 R or S)-1 -

(trans-4-methylcyclohexyl)ethyl]-3H-innidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-

5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(1 S or R)-1 -ethoxyethyl]-3-[(1 R or S)-1 -(trans-4- nnethylcyclohexyl)ethyl]-3H-innidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-2-[(1 R or S)-1 -ethoxy-2-methoxyethyl]-3-[(1 R or S)-1 - (trans-4-methylcyclohexyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol- 5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-{(2R)-4-[(1 -fluorocyclopropyl)carbonyl]-2- methylpiperazin-1 -yl}-3-[(1 R or S)-1 -(trans-4-methylcyclohexyl)ethyl]-3H- imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-2-[(trans)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-

3-[4-(trifluoromethyl)benzyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(^ one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-ethylcyclohexyl)methyl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one;

5-{4-(5-chloropyridin-3-yl)-3-[(trans-4-ethylcyclohexyl)methyl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,3,4- oxadiazol-2(3H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[3-fluoro-4-(trifluorornethyl)benzyl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-2-[(trans)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]- 3-{[trans-4-(trifluoromethyl)cyclohexyl]methyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4- oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(3-ethylcyclopentyl)methyl]-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4- oxadiazol-5(4H)-one;

3-{4-[5-chloro-2-(dimethylamino)pyridin-3-yl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloro-2-methylpyridin-3-yl)-2-[(4aS,7aS)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloro-2-methylpyridin-3-yl)-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-methylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-[5-chloro-2-(2-hydroxyethoxy)pyridin-3-yl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloro-2-methoxypyridin-3-yl)-2-[(4aS,7aS)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloro-2-methoxypyridin-3-yl)-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-[5-chloro-2-(2-methoxyethoxy)pyridin-3-yl]-2-[(4aR,7aR)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-[5-chloro-2-(2-methoxyethoxy)pyridin-3-yl]-2-[(4aS,7aS)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]- 3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

5-chloro-3-{2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4- methylcyclohexyl)nnethyl]-6-(5-oxo-4,5-dihydro-1 ,2,4-oxadiazol-3-yl)-3H- imidazo[4,5-c]pyridin-4-yl}pyndin-2(1 H)-one;

3-{2-[(4aR,7aR)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4- methylcyclohexyl)methyl]-4-(5-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin^^ 1 ,2,4-oxadiazol-5(4H)-one;

3-{2-[(4aS,7aS)-hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4- methylcyclohexyl)methyl]-4-(5-methylpyridin-3-yl)-3H-imidazo[4,5-c]pyridin^^ 1 ,2,4-oxadiazol-5(4H)-one;

3-{4-[5-chloro-2-(methylannino)pyndin-3-yl]-2-[(trans)- hexahydrocyclopenta[b][1 ,4]oxazin-4(4aH)-yl]-3-[(trans-4-nnethylcyclohexyl)nnethyl]-

3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

5-chloro-3-{3-[(trans-4-methylcyclohexyl)nnethyl]-6-(5-oxo-4,5-dihydro-1 ,2,4- oxadiazol-3-yl)-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-4- yl}pyridin-2(1 H)-one;

3-{3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-4- pyrinnidin-5-yl-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-4-(pyrazin

2- yl)-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3- {3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-4- (pyridazin-4-yl)-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-4- (pyridazin-3-yl)-3H-imidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one;

3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[1 -methyl-2- (methylsulfanyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[1 -methyl-2- (methylsulfonyl)ethyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; 3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-{1 - [(methylsulfanyl)methyl]propyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-{1 - [(methylsulfonyl)methyl]propyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol- 5(4H)-one;

3-[4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-{2-methyl-1 - [(methylsulfonyl)methyl]propyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1 ,2,4-oxadiazol- 5(4H)-one;

6-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}pyridin-2(1 H)-on

3-{4-(cyclobutylmethoxy)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; and

3-{4-(1 -cyclobutylethoxy)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3- phenylmorpholin-4-yl]-3H-innidazo[4,5-c]pyndin-6-yl}-1 ,2,4-oxadiazol-5(4H)-one; or a stereoisomer thereof;

or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt of the stereoisomer thereof.

22. A pharmaceutical composition comprising a

therapeutically effective amount of at least one compound of any one of claims 1 - 21 , in combination with at least one pharmaceutically acceptable carrier.

23. A compound according to any one of claims 1 -21 for the treatment cancer.

received by the International Bureau on 02 May 2014 (02.05.2014)

WHAT IS CLAIMED IS:

1. A compound represented by Formula I:

Wherein

R¹ is selected from the group consisting of C C₆alkyl, -(CR^a₂)_nCOOR¹¹, -T-NHR⁵, - (CR^a₂)_nNR⁵SO₂R⁶, -(CR^a₂)_nS0₂NR⁵R⁶, -(CR^a₂)nC(O)NR^cSO₂N(R^c)₂,

-(CR^a₂)_nC(0)NR^cS0₂R^c, -(CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, - (CR^a₂)_nNR⁵C(O)R⁶, -(CR^a₂)_nOR⁵, -(CR^a₂)_nS(O)R^c, -(CR^a₂)_nS(0)₂R^c, and nitrogen containing 5 or 6-membered heterocyclic, heteroaryl or heterocyclenyl ring, wherein the alkyl and 5 or 6-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹, C C₆alkyl, C C₆haloalkyl, C C₆haloalkoxy, C

C₆hydroxyalkyl, C₂-C₆alkenyl, C C₆alkyl-C(=0)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, d-Cealkylsulfonyl, C

C₆alkylamino or di(Ci-C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, C₃-C₈cycloalkyl, -W- (CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, or heterocyclic is optionally substituted with R ² selected from the group consisting of halo, CN, halod-Cealkyl, C C₆alkyl, -(CR^a₂)_zOR^c, -(CR^a₂)_zNHR⁸, - (CR^a₂)_zC(0)NR^cR^c, -(CR^a₂)_zCOOR¹⁰, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, - (CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zcyclenyl, and - (CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, -(CR^a₂)_zCOOR¹⁰, C C₆alkoxy, C C₆alkyl, C C₆haloalkyl, C_r

C₆haloalkoxy, C C₆hydroxyalkyl, C₂-C₆alkenyl, C₁-C₆alkyl-C(=O)O-, C C₆alkyl- C(=0)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, C

Cealkylsulfonyl, CrCealkylamino or di(C-i-C6)alkylamino;

R³ is selected from the group consisting of -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, -(CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸, - (CR^a₂)_qNR^cC(O)R⁸, -T-alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T-heterocyclic, -T- C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cycienyl and heterocyclenyl can be optionally substituted with halo, SR^C, OR^c, haloCi-C₆alkyl, haloC C₆alkoxy, -(CR^a₂)_zCN, d-Cealkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, - (CR^a₂)_zC(O)OR¹¹, -(CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, - (CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, - (CR^a₂)_zheterocyclic, -(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR^cR⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, heterocyclic, heterocyclenyl and cycienyl can further be substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹⁰, d-Cealkoxy, C C₆alkyl, C₂-C₆alkenyl, CrC₆haloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -SO₂R^c, -NR^cSO₂R^c C_rC₆alkylsulfonyl, C C₆alkylamino or di(CrC₆)alkylamino;

R⁴ is selected from the group consisting of C-|-C₆alkyl_, -(CR^a₂)_maryl,

-(CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)_mC₃-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cycienyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C_rC₆alkoxy, C C₆alkyl, C₃-C₆cycloalkyl, haloC₂-C₆alkenyl, C₂-C₆alkenyl, C₂-C₆alkenoxy, CrCehaloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c CrC₆alkylsulfonyl, C C₆alkylamino or di(Ci-C₆)alkylamino;

R⁵ is independently selected from the group consisting of H, C-i-Cealkyl, -C₀-C₆alkyl- C₃-C₈cycloalkyl, -C₀-C₆alkyl-heteroaryl, -Co-Cealkyl-aryl, and -Co-C₆alkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C₃alkenyl, C₃-C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, C C₃alkylamino, C C₃dialkylamino or COOR¹¹;

R⁶ is independently selected from the group consisting of H, CrCealkyl, -C₀-Cealkyl- C₃-C₈cycloalkyl, -C₀-C₆alkyl-heteroaryl, -C₀-C₆alkyl-aryl, and -Co-C₆alkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryi, aryl, and heterocyclic can be optionally substituted with C₂-C₃alkenyl, C₃-C₆cycloalkyl, d-Csalkoxy, OH, halo, ΝΗ₂, C_r C₃alkylamino, CrC₃dialkylamino or COOR¹¹;

R⁷ is selected from the group consisting of H, C Cealkyl, C₂-C₆alkenyl, C₃- Cscycloalkyl, aryl, heteroaryi, and heterocyclic, wherein the alkyl, alkenyl, cycloalkyi, aryl, heteroaryi or heterocyclic can be optionally substituted with halo, nitro, CN, Cr Cehaloalkyl, C-i-Cehaloalkoxy, C₂-C₆alkenyl, C₂-Cealkynyl, CrC₆alkyl, -C₀-C₆alkyl- C₃-C₈cycloalkyl, -C₀-C₆alkyl-heteroaryl, -C₀-C₆alkyl-aryl, -Co-C₆alkylheterocyclic, -Co- Cealkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNR⁵R⁶, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)_zSO₂NR⁵R⁶, -(CR^a₂)_zC(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)_zNR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, or - (CR^a₂)_zS(O)₂R^c;

R⁸ is independently selected from the group consisting of H, -(CR^a₂)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a₂)sC₃-C₇cycloalkyl, and d-Cealkyl, wherein the heteroaryi, aryl, heterocyclic, heterocyclenyl, cyclenyl, cycloalkyi, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C C₆alkoxy, C C₆alkyl, C₂-C₆alkenyl, heterocyclic, CrCehaloalkyl, CrC₆haloalkoxy, CrC₆hydroxyalkyl, CrC₆alkyl- C(=O)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, - NR^cSO₂R^c C C₆alkylsulfonyl, C C₆alkylamino or di(C C₆)alkylamino;

R⁹ is independently selected from the group consisting of H, CrC₆alkyl, C

C₆haloalkyl, C₃-C₈cycloalkyl, aryl, heteroaryi, and heterocyclic, wherein the alkyl, cycloalkyi, aryl, heteroaryi, and heterocyclic can be optionally substituted with -C₀- C₆alkylOR^c, -Co-C₆alkylN(R^c)₂, COOR¹⁰, nitro, CN, C C₆alkyl, C C₆haloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C₂-C₆alkenyl, CrC₆alkyl-C(=O)O-, C C₆alkyl- C(=0)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C

C₆alkylsulfonyl, heterocyclic, or C(O)NHR^c;

R¹⁰ is independently selected from the group consisting of C-i-Cealkyl, -(CR^C₂)_ZC₃- Cscycloalkyl, -(CR^c₂)_z-heteroaryl, -(CR^c₂)z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C C₆alkyl, OH, halo, or haloC C₆alkyl;

R¹¹ is independently selected from the group consisting of H, -(CR^C₂)_ZC₃- C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with CrC₆alkyl, C C₆alkoxy, OH, halo, or halod-C₆alkyl;

R¹⁷ is independently selected from the group consisting of H, halo, COOH, oxadiazolone, C C₆alkyl, C C₆alkoxy, NR^CR°, -(CR^c₂)_zC₃-C₈cycloalkyl, - (CR^C2)_zheteroaryl, -(CR^C2)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C Cealkyl, OH, halo, or haloC Cealkyl;

R^a is independently H , C(O)NR^c₂, OR^c, NH₂, halo, CrC₆alkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, C-pC^alkoxy, NH₂, halo, haloCr C₄alkyl, C₃-C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or CrC₄alkyl optionally substituted with C₂-C₃alkenyl, C₃- Cecycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or C₁-C₃dialkylamino;

T is independently C₂-C₃alkenyl, -C(O)-, -(CR^a₂)_q-, -C(=CH₂)-, -(CR^a₂)_q-C(=CH₂)-, -C(=CH₂)-(CR^a₂)_q-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^c-;

U is H, COOR ¹, OH, heteroaryl or heterocyclic; n is independently 0, 1 , 2 or 3; m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 represented by Formula I:

Wherein

R¹ is selected from the group consisting of C C₆alkyl, -(CR^a₂)_nCOOR¹¹, -T-NHR⁵, - (CR^a₂)nNR⁵SO₂R⁶, -(CR^a₂)_nSO₂NR⁵R⁶, -(CR^a₂)_nC(O)NR^cSO₂N(R^c)₂,

-(CR^a₂)_nC(O)NR^cSO₂R^c, -(CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, - (CR^a₂)_nNR⁵C(O)R⁶, -(CR^a₂)_nOR⁵, -(CR^a₂)_nS(O)R^c, -(CR^a₂)_nS(O)₂R^c, and nitrogen containing 5 or 6-membered heterocyclic, heteroaryl or heterocyclenyl ring, wherein the alkyl and 5 or 6-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹, C C₆alkyl, C C₆haioalkyl, C C₆haloalkoxy, C

C₆hydroxyalkyl, C₂-C₆alkenyl, C C₆alkyl-C(=O)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C C₆alkylsulfonyl, C

C₆alkylamino or di(Ci-C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, -W-(CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, or heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloCrCealkyI, C C₆alkyl, -(CR^a₂)₂OR^c, -(CR^a₂)_zNHR⁸, -(CR^a₂)_zC(O)NR^cR^c, - (CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃-C₈cycloalkyl, - (CR^a₂)_zcyclenyl, and -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, -(CR^a₂)₂COOR¹⁰, C C₆alkoxy, C C₆alkyl, C C₆haloalkyl, CrC₆haloalkoxy, CrC₆hydroxyalkyl, C₂-C₆alkenyl, C

C₆alkyl-C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, - SO₂NR^cR^c, -NR^cSO₂R^c_, Ci-C₆alkylsulfonyl, C C₆alkylamino or di(CrC₆)alkylamino;

R³ is selected from the group consisting of -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, -(CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸, - (CR^a₂)_qNR^cC(O)R⁸, -T-alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T-heterocyclic, -T- C₃-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl can be optionally substituted with halo, OR^c, haloCrCealkyI, haloCr C₆alkoxy, -(CR^a₂)_zCN, C C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR¹¹, - (CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, - (CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR°R⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, heterocyclic, heterocyclenyl and cyclenyl can further be substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR¹⁰, CrC₆alkoxy, C C₆alkyl, C₂-C₆alkenyl, CrC₆haloalkyl, C C₆haloalkoxy, C

C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c_, C C₆alkylsulfonyl, C C₆alkylamino or di(Ci-C₆)alkylamino;

R⁴ is selected from the group consisting of C C₆alkyl, -(CR^a₂)_maryl, - (CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)_mC₃-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C C₆alkoxy, d-C₆alkyl, C₃-C₆cycloalkyl, haloC₂-C₆alkenyl, C₂-C₆alkenyl, C₂-C₆alkenoxy, C C₆haloalkyl, CrC₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, C C₆alkylsulfonyl, CrC₆alkylamino or di(Ci-C₆)alkylamino;

R⁵ is independently selected from the group consisting of H, C C6alkyl, -Co-C₆alkyl- C₃-C₈cycloalkyl, -Co-C₆alkyl-heteroaryl, -Co-C₆alkyl-aryl, and -Co-Cealkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C₃alkenyl, C₃-C6cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, C C₃alkylamino, Ci-C₃dialkylamino or COOR¹¹ ;

R⁶ is independently selected from the group consisting of H, CrC₆alkyl, -Co-C₆alkyl- C₃-C₈cycloalkyl, -Co-C₆alkyl-heteroaryl, -Co-C₆alkyl-aryl, and -C₀-C6alkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C₃alkenyl, C₃-C6cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, C C₃alkylamino, CrC₃dialkylamino or COOR¹¹ ;

R⁷ is selected from the group consisting of H, CrC₆alkyl, C₂-C₆alkenyl, C₃- C₈cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, alkenyl, cycloalkyi, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, C C₆haloalkyl, d-Cehaloalkoxy, C₂-C6alkenyl, C₂-C6alkynyl, Ci-C₆alkyl, -C₀-C6alkyl- C₃-C₈cycloalkyl, -C₀-C6alkyl-heteroaryl, -Co-C₆alkyl-aryl, -Co-C6alkylheterocyclic, -Co- C₆alkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNR⁵R⁶, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)_zSO₂NR⁵R⁶, -(CR^a₂)₂C(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)_zNR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, or - (CR^a₂)_zS(O)₂R^c;

R⁸ is independently selected from the group consisting of H, -(CR^a₂)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a₂)_sC₃-C₇cycloalkyl, and C-t-Cealkyl, wherein the heteroaryl, aryl, heterocyclic, heterocyclenyl, cyclenyl, cycloalkyi, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , CrC₆alkoxy, C_rC₆alkyl, C₂-C₆alkenyl, C

C₆haloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, Ci-C₆alkyl-C(=O)O-, C C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C

C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino; R⁹ is independently selected from the group consisting of H, C-i-Cealkyl, C

C₆haloalkyl, C₃-C₈cycloalkyl, aryl, heteroaryi, and heterocyclic, wherein the alkyl, cycloalkyi, aryl, heteroaryi, and heterocyclic can be optionally substituted with -Co- C₆alkylOR^c, -C₀-C₆alkylN(R^c)_2> COOR¹⁰, nitro, CN, C C₆alkyl, C Cehaloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C₂-C₆alkenyl, C C₆alkyl-C(=O)0-, C C₆alkyl- C(=0)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -S0₂NR^cR^c, -NR^cSO₂R^c, C

C₆alkylsulfonyl, heterocyclic, or C(O)NHR^c;

R¹⁰ is independently selected from the group consisting of CrC₆alkyl, -(CR^C₂)_ZC₃- C₈cycloalkyl, -(CR^C2)_z-heteroaryl, -(CR^c₂)_z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryi, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C C₆alkyl, OH, halo, or haloCi-C₆alkyl;

R ¹ is independently selected from the group consisting of H, C-i-Cealkyl, -(CR^C₂)_ZC₃- Cscycloalkyl, -(CR^C2)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryi, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C C₆alkyl, OH, halo, or haloC C₆alkyl;

R¹⁷ is independently selected from the group consisting of H, halo, COOH, oxadiazolone, Ci-C₆alkyl, -(CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)₂aryl, and -(CR^C2)_zheterocyclic wherein the heteroaryi, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with CrC₆alkyl, OH, halo, or haloCrC₆alkyl;

R^a is independently H , C(O)NR^c₂, OR^c, NH₂₎ halo, CrC_ealkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, CrC₄alkoxy, NH₂, halo, haloCr C₄alkyl, C₃-C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or CrC₄alkyl optionally substituted with C₂-C₃alkenyl, C₃- C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or Ci-C₃dialkylamino;

T is independently C₂-C₃alkenyl, -C(O)-, -(CR^a₂)_q-, -C(=CH₂)-, -(CR^a₂)_q-C(=CH₂)-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-; Y is a bond, -C(0)NR^c-, -NR^cC(O)-, or -NR^c-;

U is H, COOR , OH, heteroaryi or heterocyclic; n is independently 0, 1 , 2 or 3;

m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2,

Wherein

R is selected from the group consisting of C C₆alkyl, -(CR^a₂)_nCOOR ¹, -T-NHR⁵, - (CR^a₂)nNR⁵SO₂R⁶, -(CR^a₂)_nSO₂NR⁵R⁶, -(CR^a₂)_nC(O)NR^cSO₂N(R^c)₂, -(CR^a₂)_nC(O)R⁵, -(CR^a₂)_nCONR⁵R⁶, -(CR^a₂)_nCONR⁵OR⁶, -(CR^a₂)_nNR⁵C(O)R⁶, -(CR^a₂)_nOR⁵, - (CR^a₂)_nS(O)R^c, -(CR^a₂)nS(O)₂R^c, and nitrogen containing 5-membered heterocyclic, heteroaryi or heterocyclenyl ring, wherein the alkyl and 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹, CrC_ealkyl, C C₆haloalkyl, CrC₆haloalkoxy, C C₆hydroxyalkyl, C₂-C₆alkenyl, C C₆alkyl-C(=O)O-, CrC₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, - NR^cSO₂R^c, CrC₆alkylsulfonyl, CrC₆alkylamino or di(C C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryi, -W-(CR^aR⁹)_tR⁷, and heterocyclic, wherein W is NR° or O, wherein the aryl, heteroaryi, or heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloC C₆alkyl, C C₆alkyl, -(CR^a₂)_zOR^c, -(CR^a₂)_zNHR⁸, -(CR^a₂)_zC(O)NR°R^c, - (CR^a₂)_zCOOR¹⁰, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃- C₈cycloalkyl, -(CR^a₂)_zcyclenyl, and -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl of R¹² can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)_2l -(CR^a₂)_zCOOR¹⁰, C

C₆alkoxy, C-i-C₆alkyl, d-Cehaloalkyl, CrC₆haloalkoxy, C-i-Cehydroxyalkyl, C₂- C₆alkenyl, C C₆alkyl-C(=O)O-, C C6alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, CrC₆alkylsulfonyl, CrCealkylamino or di(CrC₆)alkylamino;

R³ is selected from the group consisting of -(CR^a₂)_qNR^cR⁸, -(CR^a₂)_qOR⁸, -(CR^a₂)_qSR⁸, -(CR^a₂)_qC(O)R⁸, -(CR^a₂)_qS(O)R⁸, -(CR^a₂)_qS(O)₂R⁸, -(CR^a₂)_qCONR^cR⁸,

-(CR^a₂)_qNR^cC(O)R⁸, -T-C C₆alkyl, C₂-C₆alkenyl, -T-aryl, -T-heteroaryl, -T- heterocyclic, -T-C3-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl and heterocyclenyl can be optionally substituted with halo, SH, OR^c, haloCrC₆alkyl, haloC C₆alkoxy, -(CR^a₂)_zCN, C C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, - (CR^a₂)_zC(O)OR¹¹, -(CR^a₂)_zC(O)R⁸, -(CR^a₂)₂OR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, - (CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_z C₃-C₈cycloalkyl, - (CR^a₂)_zheterocyclic,

-(CR^a₂)_zheterocyclenyl, -(CR^a₂)_zcyclenyl, -(CR^a₂)_zSO₂NR^cR⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, heterocyclic, heterocyclenyl and cyclenyl can further be substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹⁰, C C₆alkoxy, CrCealkoxyCrCealkyl, C C₆alkyl, C₂-C₆alkenyl, C

C₆haloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, C C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, C

Cealkylsulfonyl, CrC₆alkylamino or di(CrC₆)alkylamino;

R⁴ is selected from the group consisting of C-i-C₆alkyl, -(CR^a₂)_maryl, - (CR^a₂)_mheteroaryl, -(CR^a₂)_mheterocyclic, -(CR^a₂)_mC₃-C₈cycloalkyl, -(CR^a₂)_mcyclenyl, and -(CR^a₂)_mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C C₆alkoxy, C_rC₆alkyl, C₃-C₆cycloalkyl, haloC₂-C6alkenyl, C₂-C6alkenyl, C₂-C₆alkenoxy, CrC₆haloalkyl, CrC₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, C C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, CrC₆alkylsulfonyl, C C₆alkylamino or di(CrC₆)alkylamino;

R⁵ is independently selected from the group consisting of H, Ci-C₆alkyl, -C₀-C₆alkyl- C₃-C₈cycloalkyl, -Co-C₆alkyl-heteroaryl, -Co-C₆alkyl-aryl, and -Co-C₆alkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C3alkenyl, C₃-C6cycloalkyl, d-dalkoxy, OH, halo, NH₂, d- C₃alkylamino, Crddialkylamino or COOR¹¹;

R⁶ is independently selected from the group consisting of H, C Cealkyl, -C₀-Cealkyl- C3-C₈cycloalkyl, -C₀-C₆alkyl-heteroaryl, -C₀-C6alkyl-aryl, and -C₀-C₆alkylheterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl, and heterocyclic can be optionally substituted with C₂-C3alkenyl, C₃-C₆cycloalkyl, C C₃alkoxy, OH, halo, NH₂, C C3alkylamino, C C₃dialkylamino or COOR¹¹;

R⁷ is selected from the group consisting of H, C Cealkyl, C2-C₆alkenyl, C3- C₈cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, alkenyl, cycloalkyi, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, d- C₆haloalkyl, CrCehaloalkoxy, C₂-Cealkenyl, C2-C₆alkynyl, d-Cealkyl, -Co-C₆alkyl- C₃-C₈cycloalkyl, -Co-C₆alkyl-heteroaryl, -C₀-C6alkyl-aryl, -C₀-C₆alkylheterocyclic, -C₀- Cealkylheterocyclenyl, -C₀-C₆alkylcyclenyl, -(CR^a₂)_zNHR⁵, -(CR^a₂)_zNR⁵SO₂R⁶, - (CR^a₂)zSO₂NR⁵R⁶, -(CR^a₂)_zC(O)R⁵, -(CR^a₂)_zC(O)OR¹⁰, -(CR^a₂)_zCONR⁵R⁶, - (CR^a₂)_zCONR⁵OR⁶, -(CR^a₂)₂NR⁵C(O)R⁶, -(CR^a₂)_zOR⁵, -(CR^a₂)_zS(O)R^c, or - (CR^a₂)_zS(O)₂R^c;

R⁸ is independently selected from the group consisting of H, -(CR^a₂)_s-heteroaryl, - (CR^a₂)_s-aryl, -(CR^a₂)_s-heterocyclic, -(CR^a₂)_s-heterocyclenyl, -(CR^a₂)_s-cyclenyl, - (CR^a₂)sC3-C₇cycloalkyl, and CrC₆alkyl, wherein the heteroaryl, aryl, heterocyclic, heterocyclenyl, cyclenyl, cycloalkyi, and alkyl can be optionally substituted with OH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C_rC₆alkoxy, C C₆alkyl, C₂-C₆alkenyl, C

Cehaloalkyl, d-Cehaloalkoxy, d-Cehydroxyalkyl, d-C₆alkyl-C(=0)0-, d-C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C_r Cealkylsulfonyl, CrC₆alkylamino or di(CrC₆)alkylamino; R is independently selected from the group consisting of H, CrC₆alkyl, C

Cehaloalkyl, C₃-C₈cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, cycloalkyi, aryl, heteroaryl, and heterocyclic can be optionally substituted with -Co- C₆alkylOR°, C₀-C₆alkylN(R^c)₂, COOR¹⁰, nitro, CN, C C₆alkyl, C C₆haloalkyl, C C₆haloalkoxy, Ci-C₆hydroxyalkyl, C₂-C₆alkenyl, C C₆alkyl-C(=O)O-, C_rC₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -S0₂NR^cR^c, -NR^cS0₂R^c, C

C₆alkylsulfonyl, heterocyclic, or C(0)NHR^c;

R¹⁰ is independently selected from the group consisting of d-C^alky!, -(CR^C2)_ZC₃- C₈cycloalkyI, -(CR^C2)_z-heteroaryl, -(CR°₂)_z-aryl, and -(CR^c₂)_z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C C₆alkyl, OH, halo, or haloC C₆alkyl;

R¹¹ is independently selected from the group consisting of H, d-Cealkyl, -(CR^C₂)₂C₃- Cscycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)_zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with C C₆alkyl, OH, halo, or haloC C₆alkyl;

R¹⁷ is independently selected from the group consisting of H, halo, CrC₆alkyl, - (CR^c₂)_zC₃-C₈cycloalkyl, -(CR^c₂)_zheteroaryl, -(CR^c₂)_zaryl, and -(CR^c₂)₂heterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyi and alkyl can be optionally substituted with CrC₆alkyl, OH, halo, or haloCi-C₆alkyl;

R^a is independently H , OR^c, NH₂, halo, C C₆alkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, C C₄alkoxy, NH₂, halo, haloCrC₄alkyl, C₃- C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or C_rC₃alkyl optionally substituted with C2-C₃alkenyl, C₃- C₆cycloalkyl, C C₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or Ci-C₃dialkylamino;

T is independently C₂-C₃alkenyl, -(CR^a₂)_q- -C(=CH₂)-, -(CR^a2)_q-C(=CH₂)-,

-C(=CH₂)-(CR^a₂)_q-, -C(=NH)-, -(CR^a₂)_q-C(=NH)-, or -C(=NH)-(CR^a₂)_q-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^c-; U is H, COOR¹¹, OH, heteroaryl or heterocyclic; n is independently 0, 1 , 2 or 3;

m is independently 0, 1 or 2;

q is independently 0, 1 , 2, or 3;

s is independently 0, 1 or 2;

t is independently 0, 1 , or 2;

v is independently 1 , 2, 3 or 4;

z is independently 0, 1 , 2 or 3; or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3, wherein

R¹ is selected from the group consisting of COOR¹¹, -NHR^C, -NR^cSO₂R^c, -SO₂NR^cR^c, -C(O)R^c, -CONR^cR^c, -CONR^cOR^c, -OR^c, and nitrogen containing 5-membered heterocyclenyl or heteroaryl ring, wherein the 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹, C C₆alkyl, C

C₆haloalkyl, C C₆haloalkoxy, d-C₆hydroxyalkyl, C2-C₆alkenyl, C C₆alkyl-C(=O)O-, Ci-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, - NR^cSO₂R^c, C C₆alkylsulfonyl, Ci-C₆alkylamino or di(C C₆)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, W-(CR^aR⁹)R⁷, and heterocyclic, wherein W is NR^C or O, wherein the aryl, heteroaryl, and heterocyclic is optionally substituted with R¹² selected from the group consisting of halo, CN, haloC C₆alkyl, Ci-C₆alkyl, -(CR^a₂)OR^c, and -(CR^a₂)C(O)NR^cR^c, wherein the alkyl of R ² can be optionally substituted with OH, CN, halo, haloC C₆alkyl, or CON(R^c)₂;

R³ is selected from the group consisting of -NR^CR⁸, -OR⁸, -SR⁸, -C(O)R⁸, -S(O)R⁸, - S(O)₂R⁸, -CONR^cR⁸, -NR°C(O)R⁸, -T- CrC₆alkyl, C₂-C₆alkenyl, -T-aryl, -T- heteroaryl, -T-heterocyclic, -T-C₃-C₇cycloalkyl, -T-cyclenyl, and -T-heterocyclenyl,

wherein the alkyl, alkenyl, aryl, heteroaryl, heterocyclic, cycloalkyl, cyclenyl and heterocyclenyl can be optionally substituted with halo, OR^c, haloC-i-C₆alkyl, haloCr C₆alkoxy, -(CR^a₂)_zCN, C C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(O)OR¹¹, - (CR^a₂)_zC(O)R⁸, -(CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(0)₂R⁸, -(CR^a₂)_zC(0)NR^cR⁸, - (CR^a₂)₂aryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, - (CR^a₂)_zSO₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU,

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C₆alkenyl;

R⁴ is selected from the group consisting of -(CR^a₂)aryl, -(CR^a₂)heteroaryl, - (CR^a₂)heterocyclic, -(CR^a₂)C₃-C₈cycloalkyl, -(CR^a₂)cyclenyl, and - (CR^a₂)heterocyclenyl, wherein the aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl, and heterocyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹, C C₆alkoxy, C C₆alkyl, C₃-C₆cycloalkyl, haloC₂-C₆alkenyl, C₂- C₆alkenyl, C₂-Cealkenoxy, Ci-C₆haloalkyl, CrC₆haloalkoxy, CrC₆hydroxyalkyl, d- C₆alkyl-C(=O)O-, C-i-C₆alkyl-C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, - SO₂NR^cR^c, -NR^cSO₂R^c, CrC₆alkylsulfonyl, C C₆alkylamino or di(C C₆)alkylamino;

R⁷ is selected from the group consisting of C<i-C₆alkyl, C₃-C₈cycloalkyl, heteroaryl, aryl, and heterocyclic, wherein the alkyl, cycloalkyi, heteroaryl, aryl or heterocyclic can be optionally substituted with halo, nitro, CN, CrC₆haloalkyl, C-i-Cehaloalkoxy, CrCealkyl, or -(CR^a₂)_zOR^c;

R⁸ is independently selected from the group consisting of -(CR^a₂)-heteroaryl, -(CR^a₂)- aryl, -(CR^a₂)-heterocyclic, -(CR^a₂)-heterocyclenyl, -(CR^a₂)cyclenyl, -(CR^a₂)cycloalkyl, and CrC₆alkyl, wherein the heteroaryl, aryl, heterocyclic, heterocyclenyl, cyclenyl, cycloalkyi, and alkyl can be optionally substituted with OH, C-pCealkoxy, C Cealkyl, CrC₆haloalkyl, CrC₆haloalkoxy, CrC₆hydroxyalkyl, or halo group;

R⁹ is H, Ci-C₃alkyl, CrC₃haloalkyl, or C₃-C₄cycloalkyl, wherein the alkyl or cycloalkyi can be optionally substituted with OR⁰, N(R^C)₂, heterocyclic,

C(O)NHCH₂CH₂OH, C(O)NH₂, or C(O)NHC C₃alkyl;

R¹¹ is independently selected from the group consisting of H and Ci-C₆alkyl, wherein alkyl can be optionally substituted with OH or halo;

R ⁷ is independently selected from the group consisting of H and halo; R^a is independently H , OR^c, NH_2> halo, C-i-Cealkyl, or C₂-C₆alkenyl, said alkyl or alkenyl is optionally substituted with OH, CrC₄alkoxy, NH₂, F, CF₃, C3-C₆cycloalkyl, or C₂-C₄alkenyl;

R^c is independently H or C C₃alkyl optionally substituted with C₂-C₃alkenyl, C₃- C₆cycloalkyl, CrC₃alkoxy, OH, halo, NH₂, Ci-C₃alkylamino, or CrC₃dialkylamino;

T is independently -(CR^a₂)_q-, or-C(=CH₂)-;

Y is a bond, -C(O)NR^c-, -NR^cC(O)-, or -NR^c-;

U is H, COOR¹¹, OH, heteroaryl or heterocyclic; q is independently 0 or 1 ;

v is independently 1 or 2; and

z is independently 0, 1 or 2.

5. The compound of claim 3, wherein

R¹ is selected from the group consisting of COOR¹¹, -NHR^C, -NR^cSO₂R^c, -SO₂NR^cR^c, -C(O)R^c, -CONR^cR^c, -CONR^cOR^c, -OR^c, and nitrogen containing 5-membered heterocyclenyl ring, wherein the 5-membered ring can be optionally substituted with OR^c, SR^C, NH₂, nitro, CN, amide, COOR¹¹, Ci-C₆alkyl, Ci-C_e aloalkyl, C

C₆haloalkoxy, C C₆hydroxyalkyl, C₂-C₆alkenyl, C₁-C₆alkyl-C(=O)O-_> C C₆alkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c C

C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-Ce)alkylamino;

R² is selected from the group consisting of aryl, heteroaryl, and -NR°-(CR^aR⁹)R⁷, wherein the aryl, or heteroaryl is optionally substituted with R¹² selected from the group consisting of halo, CN, haloC C₆alkyl, d-C^alky!, and -(CR^a₂)OR^c, wherein the alkyl of R ² can be optionally substituted with OH, CN, halo, haloC-pCealkyl, or CON(R^c)₂; R³ is selected from the group consisting of -T-aryl, -T-heteroaryl, and -T- heterocyclic, wherein the heteroaryl, and heterocyclic can be optionally substituted with halo, OR^c, haloC C₆alkyl, haloC C₆alkoxy, -(CR^a₂)_zCN, C C₆alkyl, C₂- C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(0)OR¹¹, -(CR^a₂)_zC(0)R⁸, -(CR^a₂)₂OR⁸, - (CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(O)₂R⁸, -(CR^a₂)_zC(O)NR^cR⁸, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zSO₂NR^cR⁸, or - (CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU;

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C₆alkenyl;

R⁴ is selected from the group consisting of -(CR^a₂)aryl, -(CR^a₂)C₃-C₆cycloalkyl, and - (CR^a₂)C3-C₆cyclenyl, wherein the aryl, cycloalkyi, and cyclenyl can be optionally substituted with OH, SH, NH₂, nitro, CN, CON(R^c)₂, COOR¹¹ , C C₆alkoxy, C

C₆alkyl, C₃-C₆cycloalkyl, haloC₂-Cealkenyl, C₂-C6alkenyl, C₂-C₆alkenoxy, Cr

C₆haloalkyl, C C₆haloalkoxy, C C₆hydroxyalkyl, C C₆alkyl-C(=O)O-, d-Cealkyl- C(=O)-, C₂-C₆alkynyl, halo group, hydroxyalkoxy, -SO₂NR^cR^c, -NR^cSO₂R^c, C

C₆alkylsulfonyl, Ci-C₆alkylamino or di(Ci-C₆)alkylamino;

R⁷ is C3-C6cycloalkyl optionally substituted with halo, nitro, CN, CrC₆haloalkyl, d- C₆haloalkoxy, C C₆alkyl, or -(CR^a₂)_zOR^c;

R⁹ is C C₃alkyl;

R ⁷ is H;

and all other substituents are as defined in claim 3.

6. The compound of any one of claims 3 to 4, wherein R is COOH or a nitrogen containing 5-membered heteroaryl, heterocyclyl or heterocyclenyl ring selected from the group consisting of tetrazolyl, oxadiazolyl,

oxadiazolone, dihydro-oxadiazolyl, triazolyl, dihydro-triazolyl, dihydro-triazolone, pyrrolidinyl, and imidazolyl, wherein the nitrogen containing 5-membered ring can be optionally substituted with halo, C C₆alkyl, haloC C₆alkyl, NH₂, OR^c, SR^C, COOH, or -NR^cSO₂R^c.

7. The compound of any one of claims 3 to 4, wherein

, wherein R is CH₃ or H.

8. The compound of any one of claims 3 to 5, wherein

COOH,

9. The compound of any one of claims 3 and 7 to 8, wherein R² is

R^e is H, -(CR^a₂)_zC(O)OR¹⁰, halo, haloC C₃alkyl or C C₃alkyl;

K and L are independently CR¹⁴ or N;

R¹⁴ is independently H, halo, CN, haloC C₆alkyl, C C₆alkyl, -(CR^a₂)_zC(O)NR^cR^c, - (CR^a₂)_zOR^c, -(CR^a₂)_zaryl, -(CR^a₂)_zheteroaryl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zC₃- C₈cycloalkyl, -(CR^a₂)_zcyclenyl, or -(CR^a₂)_zheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyi, cyclenyl or heterocyclenyl can be optionally substituted with OH, CN, halo, haloC C₃alkyl, or CON(R^c)₂; and h is 0 or 1.

10. The compound of any one of claims 3-4 and 6-9, wherein R³ is -T- heterocyclic optionally substituted with halo, OR^c, haloCrC₆alkyl, haloCrC₆alkoxy, CN, C C₆alkyl, C₂-C₆alkenyl, C₂-C₆alkynyl, -(CR^a₂)_zC(0)OR¹¹, -(CR^a₂)_zC(O)R⁸, - (CR^a₂)_zOR⁸, -(CR^a₂)_zNR^cR⁸, -(CR^a₂)_zS(0)₂R⁸, -(CR^a₂)_zC(0)NR^cR⁸, -(CR^a₂)_zaryl, - (CR^a₂)_zheteroaryl, -(CR^a₂)_zC₃-C₈cycloalkyl, -(CR^a₂)_zheterocyclic, -(CR^a₂)_zS0₂NR^cR⁸, or -(CR^a₂)_zO(CR^a₂)_zY(CR^a₂)_vU;

said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyi, and heterocyclic can further be substituted with OH, halo, or C₂-C₆alkenyl.

11. The compound of any one of claims 3, and 7 to 9, wherein R³ is