Title:
SUBSTITUTED ISOQUINOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/146881
Kind Code:
A1
Abstract:
Disclosed is an isoquinoline-6-sulfonamide derivative which is useful as a novel medicinal agent.
Specifically disclosed is an isoquinoline-6-sulfonamide derivative represented by general formula (1) (wherein X and Y independently represent a direct bond, NH, CH=CH, O or S; R1 and R2 independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, or the like; R3 and R4 independently represent a hydrogen atom, an alkyl group, or the like, or R3 and R4 may together form an alkylene group or an alkenylene group and two carbon atoms at any positions in R3 and R4 may be crosslinked; and l, m and n independently represent a numeral value of 1 to 4), a salt of the derivative, or a solvate of the derivative or the salt.
Inventors:
HIDAKA HIROYOSHI (JP)
TAKAHASHI KOUICHI (JP)
INOUE YOSHIHIRO (JP)
SUMI KENGO (JP)
NAKAMURA RYOHEI (JP)
TAKAHASHI KOUICHI (JP)
INOUE YOSHIHIRO (JP)
SUMI KENGO (JP)
NAKAMURA RYOHEI (JP)
Application Number:
PCT/JP2010/004101
Publication Date:
December 23, 2010
Filing Date:
June 18, 2010
Export Citation:
Assignee:
WESTERN THERAPEUTICS INST INC D (JP)
HIDAKA HIROYOSHI (JP)
TAKAHASHI KOUICHI (JP)
INOUE YOSHIHIRO (JP)
SUMI KENGO (JP)
NAKAMURA RYOHEI (JP)
HIDAKA HIROYOSHI (JP)
TAKAHASHI KOUICHI (JP)
INOUE YOSHIHIRO (JP)
SUMI KENGO (JP)
NAKAMURA RYOHEI (JP)
International Classes:
C07D217/02; A61K31/407; A61K31/4725; A61K31/496; A61K31/5377; A61K31/551; A61P9/00; A61P25/28; A61P27/06; C07D401/12; C07D413/12; C07D487/08
Domestic Patent References:
| WO2006073448A2 | 2006-07-13 | |||
| WO2005080394A1 | 2005-09-01 | |||
| WO2008105442A1 | 2008-09-04 | |||
| WO2006073448A2 | 2006-07-13 | |||
| WO2008077553A1 | 2008-07-03 | |||
| WO2006115244A1 | 2006-11-02 |
Foreign References:
| US20060079556A1 | 2006-04-13 | |||
| US20080064681A1 | 2008-03-13 | |||
| US20060079556A1 | 2006-04-13 | |||
| US20080064681A1 | 2008-03-13 |
Other References:
LIZARZABURU, E.M. ET AL.: "Convenient preparation of aryl ether derivatives using a sequence of functionalized polymers", TETRAHEDRON LETTERS, vol. 44, 2003, pages 4873 - 4876, XP004429503
See also references of EP 2444395A4
TETRAHEDRON LETTERS, vol. 44, 2003, pages 4873 - 4876
ACTA CHEMICA SCAND., vol. 45, 1991, pages 621
J. MED. CHEM., vol. 50, 2007, pages 5627 - 5643
ACTA NEUROPATHOL., vol. 100, 2000, pages 13 - 22
J. NEUROSURG., vol. 93, no. 1, 2000, pages 94,101
See also references of EP 2444395A4
TETRAHEDRON LETTERS, vol. 44, 2003, pages 4873 - 4876
ACTA CHEMICA SCAND., vol. 45, 1991, pages 621
J. MED. CHEM., vol. 50, 2007, pages 5627 - 5643
ACTA NEUROPATHOL., vol. 100, 2000, pages 13 - 22
J. NEUROSURG., vol. 93, no. 1, 2000, pages 94,101
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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