Title:
SUBSTITUTED LACTOSYL COMPOUNDS AND USE THEREOF FOR CELLULAR IMAGING AND THERAPY
Document Type and Number:
WIPO Patent Application WO/2012/116196
Kind Code:
A3
Abstract:
The invention provides methods for producing compounds comprising a substitution at the 1'-position of a lactosyl ring. Also provided are compounds having a radionuclide, such as 18F substituted at the 1'-position of a lactosyl ring. Compounds according to the invention may be used as therapeutics or imaging agents, such as PET imaging agents. Methods for therapeutic and diagnostic use of substituted lactosyl compounds are also provided.
Inventors:
TURKMAN NASHAAT (US)
PAL ASHUTOSH (IN)
TONG WILLIAM B (US)
GELOVANI JURI G (US)
ALAUDDIN MIAN M (US)
PAL ASHUTOSH (IN)
TONG WILLIAM B (US)
GELOVANI JURI G (US)
ALAUDDIN MIAN M (US)
Application Number:
PCT/US2012/026344
Publication Date:
November 22, 2012
Filing Date:
February 23, 2012
Export Citation:
Assignee:
UNIV TEXAS (US)
TURKMAN NASHAAT (US)
PAL ASHUTOSH (IN)
TONG WILLIAM B (US)
GELOVANI JURI G (US)
ALAUDDIN MIAN M (US)
TURKMAN NASHAAT (US)
PAL ASHUTOSH (IN)
TONG WILLIAM B (US)
GELOVANI JURI G (US)
ALAUDDIN MIAN M (US)
International Classes:
C07H3/04; A61K31/7016; A61K31/7028; A61K31/7056; A61P35/00; C07H7/02; C07H17/02
Foreign References:
| US20100322858A1 | 2010-12-23 | |||
| US20100111863A1 | 2010-05-06 | |||
| US20100290988A1 | 2010-11-18 | |||
| US20090105184A1 | 2009-04-23 |
Other References:
TURKMAN, N. ET AL.: "Radiosynthesis of 1-[18F]fluoroethyl-beta-D-lactose ([18F]-FEL) for early detection of pancreatic carcinomas with PET", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 54, 25 March 2011 (2011-03-25), pages 232 - 238
Attorney, Agent or Firm:
BYRD, Marshall, P. (98 San Jacinto BoulevardSuite 110, Austin TX, US)
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